Stimulants Change my mind - Epinephrine

[Rads0y]

I’ve done a small amount of reading up on people’s experiences with epinephrine. 9/10 times it is a negative report.

Since I’ve started probation a couple of years ago I’ve spent a lot of time finding alternative chemicals to use that will not show up on both a rapid test nor a lab test.
It’s also worth noting that I have been slowly moving away from the hardcore drug use that characterized my teens & 20’s.

Given that info, I’m also simply interested in “lighter” chemicals, although epinephrine hardly seems “light”, but imo it’s far from IV coke/H/fent/meth/etc.
Chemicals like Cyclazodone, Baclofen, soma, G, maybe some light K, sniffing caffeine powder, DMT, phenibut.
I still have yet to try the isolated/extracted 7-oh, Selank, Semax, and plennnty of other chems I’ve tried and have yet to try.

Most recently I’ve ordered some smelling salts, and a variety of different kinds of poppers. I’d like to conjure up some ether as well.

While I’ve been waiting for my smelling salts, I decided to get a primatene inhaler to kick off the day when I have to get up super early, which I’m terrible at, hence the chems.
I use it very lightly because it can easily be too much. It pretty much does the job, wakes me up quickly, and has some atypical euphoria to it. I’ll maybe use it another 2-3 times through the day currently.

It definitely feels like something that should not be used long term though.
I feel like I should mention that I also take Desvenlafaxine daily which is an SNRI, which interestingly enough I also get some mild atypical euphoria from & maybe they’re interacting together.

I’m kind of assuming the smelling salts will be exactly the quick jolt I’m looking for. It doesn’t be euphoric, but If I could mix one of my poppers with the salts to provide some euphoria with the energy boost - well then that would be excellent.

But if all this fails, I’ll probably continue with the epinephrine. I just found out they make tablets of it as well. I’ll do my best to be careful, I’m not interested in trying to IV or boof it.

Any thoughts? Anyone want to convince me otherwise or throw in your two cents regarding the atypical euphoria? “Atypical” is the key word, it’s no where near the type of euphoria from our standard street drugs.

EDIT: any chance of converting epinephrine to norepinephrine with ease? If that’s a thing worth doing

 

[Docta]

I feel like I should mention that I also take Desvenlafaxine daily

Yeah Desevenlafaxine is a norepinephrine reuptake inhibitor so likely to supercharge the effects of Adrenaline (epinephrine).
Obviously there's gonna be elevated heart rate and blood pressure.
Possible long-term cardio vascular issues down the line, so you gotta ask yourself: Is the juice worth the squeeze?

any chance of converting epinephrine to norepinephrine with ease?

That would be going in the wrong direction. So not easy.
While going from norepinephrine to epinephrine in one or two steps wouldn't be an issue, going the other way would be a bit tricky.
Chemically you wanting to go from secondary amine to primary amine, this would require some experience and specialized equipment to carryout.

 

[Rads0y]

Yeah Desevenlafaxine is a norepinephrine reuptake inhibitor so likely to supercharge the effects of Adrenaline (epinephrine).
Obviously there's gonna be elevated heart rate and blood pressure.
Possible long-term cardio vascular issues down the line, so you gotta ask yourself: Is the juice worth the squeeze?



That would be going in the wrong direction. So not easy.
While going from norepinephrine to epinephrine in one or two steps wouldn't be an issue, going the other way would be a bit tricky.
Chemically you wanting to go from secondary amine to primary amine, this would require some experience and specialized equipment to carryout.

Thanks for the reply.

I basically have 0 chemistry knowledge, I just kind of assumed how the body breaks down say; oxycodone to noroxycodone by demethylation, that the “nor” always denotes like a breakdown of a parent chemical.
I know words and terms, some basic concepts, and have done some elementary extraction, conversions, etc.

Yeah I definitely don’t plan on using it long term. It’s just nice when I discover a chemical that has some mild or subtle effects that I can use on occasion.

Theoretically if I had some powdered or liquid norepinephrine , whatever form it may come in, would it have any recreational value on its own?

With cocaine IN never produced any desirable effects. Then I spent years IV’ing it which override my love for heroin for a while. I’m not 100% exact on how cocaine affects norepinephrine - but could pure norepinephrine mimic cocaine?
Is this a thing to your knowledge?

Thanks for entertaining my novice questions

 

[drewbocop]

...what are you getting out of this, exactly? This whole thing doesn't exactly sound pleasurable... How the fuck does norepinephrine have any recreational value? What? I don't really know how anyone is supposed to change your mind with sympathomimetic catecholamines... are you looking to feel like you're about to die?

Lol, literally every other drug you mentioned is a far better-suited option for what you're trying to achieve. Neurotransmitters in the body intended for stress responses aren't exactly what I would consider a good drug. You ask "any thoughts?" and my answer is "Yeah, what the fuck, why?"

Just take some kratom or something, dude.

 

[Docta]

that the “nor” always denotes like a breakdown of a parent chemical.

Yeah don't get me started, "nor-" as a prefix is a pain in the ass. It not only denotes the removal/displacement of methyl and ethyl groups down to single carbon atoms but also a term for normal what ever the hell "normal" means.

norepinephrine , whatever form it may come in, would it have any recreational value on its own?

I'm gonna say no, honestly if you're receiving a treatment that involves Desvenlafaxine there's a better than even chance you're not handling high stress environments that well. The addition of adrenaline or noradrenaline amplified by SNRI is not going to be a pleasurable experience.

The other thing to keep in mind is adrenaline a secondary amine probably wont trip the basic 5-panel drug test, whereas noradrenaline a primary amine will result in false positive for amphetamine 100% of the time. What @drewbocop says above is a better option, I don't know if kratom is a controlled substance where you live but I doubt a lab would be testing for 7-OH so that maybe a better option.

but could pure norepinephrine mimic cocaine?

lol no, adrenaline is a last line of defense hormone/neurotransmitter that the body releases in "fight-or-flight" situations.
Noting like the elevated self-esteem and feelings of invincibility associated with cocaine, exactly the opposite.

 

[Skorpio]

There are two major issues with this idea. First; that norepinephrine activity is inherently pleasurable. The many comments in this thread cover that quite thoroughly. Norepinephrine works in concert with dopamine and serotonin in most pleasurable stimulants like cocaine or methamphetamine.

So what if you were to ingest serotonin, dopamine, and norepinephrine together?

This leads to the second issue. In your brain these things function as neurotransmitters, not hormones. Hormones are released into the blood and diffuse like ink dropped into a swimming pool. They activate a whole host of receptors located on nearby tissue, and have a pretty profound effect on physiology, like how dopamine signaling in the kidney drop blood pressure.

Neurotransmitters function as pulses. Discrete amounts of these compounds are released onto terminals of specific neurons, then rapidly degraded. This gives a much finer degree of spatial and temporal fidelity, allowing for neurons to talk to other neurons in specific circuits.

People enjoy drugs which increase the levels of monoamines (serotonin, dopamine, and norepinephrine) like stimulants. These typically induce the release or inhibit the removal of monoamines from the synapse between neurons. Simply raising the plasma levels of these neurotransmitters is not enough to get them into the synapses at sufficient quantities, and will result in a lot of nasty off target effects due to the blood brain barrier keeping them away from the brain.

Even injecting them into the spinal cord (a real route of drug administration; see ziconotide) which bypasses the blood brain barrier, would not yield effects either as potently or as pleasant as using a drug to manipulate levels at the synapses.

 

[notsmokeymcpot42088]

basic 5 panel -- man what are the 5 panels I will list a shitload of drugs you will enjoy --- no lab afterwards?

No Dimethocaine cut with 4fma did not replicate coke so not a chance...... but it sounds like you have a ton of options and you seem smart enough to know this