update on soma withdrawal, it's been 2 weeks since I last had any, anxiety, depression, mood swings are starting to reduce, I am taking occasional diazapam as required but no more than 20mg twice a week, with 1 week on 1 week off. reoccurring headaches have been a theme, today for the 1st time in a week I got the joint ache issue again but much milder.
overall withdrawal effects are much less acute and I'm handling things without needing to hit lots of other drugs hard.
my overall intake of the many drugs I take is generally reducing as well, I'm in a better place.
I think the reality of this is that I mistakenly developed a dependence but got lucky that I wasn't in too deep that going cold turkey wasn't a living hell like it would have been on benzos.
I count myself lucky to have had a gentle reminder, and not something much worse.
cross posting here from another thread to keep useful info in 1 place
This is quite interesting to chat to someone who knows about all this stuff!
you're giving me far too much credit
So do you get the initial 'drunk-like, euphoric, energised, high' after about 20 minutes or so, and then some additional effects several hours later?
drunk like yes, but mainly just very relaxing for me, it's like the end of a hard day having a sit down and a relax in a warm bath (but without the heat), and mild euphoria from the Carisoprodol, but the Meprobamate take a good 2 hours to kick in.
I don't get any energised feelings myself but that is 1...
@placebonaut I'm not sure if the whole pro-drug conversion to meprobamate has ever worked for me. I gather this only happens for a small fraction of the dose? So you may not even feel it?
hmm I just tried to have a look and can't find any clear answer on the amount the does get converted, seems a much more complex calc than I expected, typically it seems it's as low as 25-30% from a quick search, much lower than I thought!
typical meprobamate dosage was in the order of 400-600mg back in the day so 2g of soma is in the right ball park to get the effect, though even with my tolerance I would struggle to eat that in 1 sitting, I need to redose about an hour or 2 later before I get the meprobamate feeling I love - seems things are starting to add up for me at least. I will eat soma earlier in the day (like 11am) and then redose, then I get the nice warm effects in the evening, especially when coupled with weed and a few beers.
given YMMV and CYP2C19 variance maybe this is another reason why some people find it hit or miss/doesn't work for them, you might just need to build up the levels of meprobamate in your system to get the effect, or be taking quite large doses of soma which is a bit of a problem for staying awake unless you redose a lot (not something I would ever do honest!)
interesting topic but my brain is too full of screaming children to chase this rabbit hole right now
So do you get the initial 'drunk-like, euphoric, energised, high' after about 20 minutes or so, and then some additional effects several hours later?
I love the initial reaction, that must be just the action of the Soma, because AFAIK pro-drug conversions take longer than 20 minutes to take effect?
Is the meprobamate high, different to the Soma high, or a similar kind of thing?
Maybe I'm wrong about the pro-drug conversions taking a long time, and maybe I metabolise it very quickly, or something, as the feelings I enjoyed so much sound similar to what I would expect from a barb-like substance.
It would be quite some substance if it delivered two separate sets of highs, a few hours apart!?
It's annoying that I've ruined my tolerance to the good effects. I guess that's the way things go with meds, the more you use them, the more you get used to the recreational effects, until eventually, you just don't feel them at all anymore.
This may be reversible with time, but now, I'll probably always be susceptible to quickly gaining a tolerance to the recreational effects, in future.
They probably would still work just fine for their intended medical purpose of muscle relaxants.
This is quite interesting to chat to someone who knows about all this stuff!
you're giving me far too much credit
So do you get the initial 'drunk-like, euphoric, energised, high' after about 20 minutes or so, and then some additional effects several hours later?
drunk like yes, but mainly just very relaxing for me, it's like the end of a hard day having a sit down and a relax in a warm bath (but without the heat), and mild euphoria from the Carisoprodol, but the Meprobamate take a good 2 hours to kick in.
I don't get any energised feelings myself but that is 1 thing that does get reported for some people, wish I had it!
I love the initial reaction, that must be just the action of the Soma, because AFAIK pro-drug conversions take longer than 20 minutes to take effect?
yeah 1st 1.5 hours is pure Carisoprodol for me, pro-drug conversation is in the order of 2 hours give or take
Is the meprobamate high, different to the Soma high, or a similar kind of thing?
Meprobamate is very different, much more similar to the lude analogues we had earlier in the year
Maybe I'm wrong about the pro-drug conversions taking a long time, and maybe I metabolise it very quickly, or something, as the feelings I enjoyed so much sound similar to what I would expect from a barb-like substance.
it will be different for people based on personal CYP2C19.
it's all about the barb type effect for me, the intial soma is a nice bonus and pairs very well with 2 beers and a joint, just be careful not to eat too many or you'll hit the soma shuffle or go nap time, hence why a bit of caffine is a must for me to help me up the dose a bit.
It would be quite some substance if it delivered two separate sets of highs, a few hours apart!?
that's just what it does, issue is that the 2nd high is weak because of the 23-30% conversation hence the redosing
It's annoying that I've ruined my tolerance to the good effects. I guess that's the way things go with meds, the more you use them, the more you get used to the recreational effects, until eventually, you just don't feel them at all anymore.
yeah I've got a good bit of tolerance to it myself so on an extended break right now.
Though given Meprobamate acts on GABA-A I would expect that there is some cross tolerance with benzos, though IIRC when I looked for studies there wasn't a great deal there, no doubt because of the timeline overlap between Meprobamate being withdrawn and benzo's becoming mainstream.
not sure what your GABA-A tolerance is like right now but that might play into things as well
This may be reversible with time, but now, I'll probably always be susceptible to quickly gaining a tolerance to the recreational effects, in future.
They probably would still work just fine for their intended medical purpose of muscle relaxants.
tolerance is meant to build very fast with Carisprodol, though all the studies I've looked at tend to relate that to daily/multiple times per day usage and tolerance over weeks when take like that.
I was taking 1-2g every 2-4 days for about 18 months and still getting a decent Carisprodol effect, though certainly it weaken over time, but my escalating dosage was much more about getting the Meprobamate effect.
dammit, what I would give for some nice barbs or ludes, I know that's what I really want!
