Thanks so much for your quick response!! My friend has taken fentanyl before but never with vyvanse. Somewhat recently prescribed, I know he is being truthful that its not being abused and only taken as prescibed but does get speedy effects from it. (unlike last time it was prescribed it had speed like effects and then after taking it for so many years, felt absolutely nothing so got off, now been back on for about 3months or so) he has normal or low tolerance for fent since it is very rarely used. He cuts 50mcg patch in half and that lasts great, pretty strong for two days never anything for third day, but nothing stopping him from doing anything on first two days, (if anything he does more, cleaning, extra interactive and more playful, very active, likes hiking, etc). So assuming with your response he should probably be okay to take med at normal time, just wanted to give you all details in case I missed something. (i took an ambien that I'm prescribed, and still can't sleep so my brain is not exactly all here so please excuse me). Thanks so much!