Jay I have to disagree and Im not here to argue with you, however, calling me misinformed here is far from accurate. Not to mention I am not saying that this accounts for everyone either.
Your saying that mixing uppers and downersw have no effect on your heart rate? Well I'm referring to the yo-yo effect, which is where you play the drugs against each other.. Take the stims to stay up and party, then take the downers to come down off the stim and visa versa, that is how these are most commonly mixed and how I was refering to them, when taken together at the same time the drug whos foot print in the bodies chemistry plus the variable of the person themselves will govern how the heart rate goes. It is a proven fact that Stims tend to create increased blood flow which induces high blood pressure and usually in accompanied by and increased heart rate, and on the flip side, downers tend to lower the blood pressure and unless in WD tend to lower the heart rate. These are not things I made up, this is how the drugs work, this is what we are taught as medics to help understand whats going on with a person of whom we know they have ingested something but don't know what. I have been a medic for alomst 20 years, so you can't tell me that for 20 years they have been training medics wrong with the effects that the drugs have on the body. So the only thing I was really wrong here is saying is that it plays a game on your heart rate, well games are fun and this is no fun!
You are also assuming that all people who do drugs of any type are in perfect health and should know better then to take meds / drugs when they have underlying conditions. There my friend is where we differ greatly. 90% of the people who are abusing drugs of any sort, are generally NOT healthy people. They are not your track stars and if they were, I would worry more, but thats a story for another day. Your assumptions that people are perfectly healthy who do these things is just unrealistic. I have rarely met a "perfectly healthy" addict as you are saying they are.
Again, Im not going to battle back and forth with you on this, but the facts are the facts, look it up in any medical literature of the effects of these meds on the body. And again, Im talking about the yo-yo effect and not just taking a mouthfull of both together as noone can predict how the body will react from that. But taken at different time and at high enough doses to where you feel an effect from the drug most definitely have the effects I mentioned for the most part, keep in mind that there are exceptions to every rule, and Im sorry to say but them being healthy is not one I usually add to the equation, not in almost 20 years up picking up people who are practically dead from their party.
I will agree with one of your statements however..
It is well known that anyone with circulatory diseases should not do most if any recreational drugs...
ABSOLUTELY it is well known that they shouldn't... Now you need to tell the addicts / users that because generally they really don't care as long as they get their high.
If its any consolation, I reread how I originally type that jay and it does seem I was suggesting that having both drugs in the body together cause an interal confusion of like a rapid give and take, but that wasnt how it was meant. I should have stated that the mix meaning taking the stims, then later taking the downers or visa vera over a "period of time" can cause this problem. By no means did I mean that while you were on both the drugs would be vollying for control, which is how I believe you read that to be. My apologies there. Sorry for that confusion.