(butylscopolamine) smoking buscopan and tripping

[3dmusic]

I thought I would put this http://www.erowid.org/experiences/exp.php?ID=17575 in here to enquire if anyone knows if it is worth doing?
I haven't been able to find any more info onine about smoking buscopan and tripping. The guy on erowid mentions buscopan helped him quit smoking, he was a moderate smoker.
Is it worth doing?
or is the guy on erowid talking b0ll0cks?
Many thanks

 

[Amberthefrog]

Buscopan acts as an anticholinergic, so in theory yes; if you can get it across the blood brain barrier it would be psychoactive.

The problems are twofold, firstly it doesn't readily cross the BBB. Will smoking change this? I don't see why it would, the N-butylbromide substitution is what prevents BBB diffusion, smoking won't remove this substituant. The only reason smoking *may* make a difference is by facilitating a higher peak plasma concentration of the drug, *some* buscopan will cross the BBB, greater p.p.conc will mean greater CNS conc. Maybe.

The second problem is the nature of the beast. Anticholinergics are neither fun or safe.

Is it worth trying? Doubtful. I certainly wouldn't recommend it, for safety's sake if nothing else.

 

[Thorns Have Roses]

^Sounds about right to me.

This does not seem like a fruitful avenue to pursue, even if central anticholinergic effects are desired. It's easy enough to get your hands on a more efficacious one, and actually be able to predict dose/effects.

 

[Burn it up]

While an oral ROA would definitely not produce effects due to the Blood Brain Barrier preventing the drug from entering, smoking would in fact work. Apparently, one of the pyrolisis products of butylsopolamine is actually scopolamine. Take a look at this: Formation of Scopolamine from N-Butyl-Scopolammonium Bromide in Cigarettes - http://jat.oxfordjournals.org/content/31/4/220.full.pdf