Ovideo_1978
Greenlighter
- Joined
- May 30, 2019
- Messages
- 25
A question, if I take Clonidina a alfa 2 agonist, have I any chance that Methylphenidate don`t have effect on NA stimulating ? Also that I have only DA stimulated.
N&PD Moderators: Skorpio | someguyontheinternet
Not exactly, c.f. para cis-propenyl phenyltropaneNot gonna happen. Dopamine and NE are too structurally related nt's to not work exclusively...
because there is no "endorphin transporter", endorphins are not monoamines, they are much larger peptides
it sounds to me like opioids are not the solution to whatever your problem is.
For uptake yes. I suppose endogenous NE and DA flooding will always have crossover and maybe a ceiling effect for transporter fooling with. That's why in theory, exogenous ligands for receptors thereof may be favorableIs there not some reciprocal activity of the transporters, e.g. NE has some affinity for DAT and DA has some affinity for NET?
Is there one kind of neuron for dopamine/norep/ep?
Also you don`t add a Serotonin agonist, also you only stimulate the endogenous with SSRI for example.