I don`t eat saturated fats, no sugar, no fast carbohydrates (sugar, white bread, rice, potatoes, etc), only whole grain bread, I take L-tyrosine (but no effect on dopamine), this I do from years. Sport I make bicycle 4 hour per week, daily one hour home with 65 % from maximul permited pulse, also how the rule is. Didn`t help.
Roxford took today for example 10 mg Selegiline but nothyng goog happened, I had strong head ashe. Perhaps one day is nothing.
I will consider Tolcapone, methylphenidate didn`t work, i had only more anxiety.
Ok. You should not take selegiline without a doctor's supervision. Even though the risk for hypertension and especially serotonin syndrome are much lower than with the non-selective MAOIs, these risks still exist. Also, of course you won't get euphoria from taking a MAO-B inhibitor. Inhibiting the breakdown of dopamine by inhibiting the enzymes responsible for catabolyzing it increases dopamine
slowly. This is not like taking a DRI, that causes a fast and dramatic increase in extracellular dopamine by stopping it from being pumped out from the synapsis. Also, selective MAO-B inhibitors are only modestly effective at boosting dopamine since dopamine is broken down equally by MAO-A and MAO-B. However, it does modestrly increase the accumulation of dopamine, and once PEA reaches a high level in the brain, it acts as a substrate for DAT and increases dopamine even more. But that takes 3-6 weeks. It will increase your dopamine levels, but not massively. This is why MAO-B inhibitors are used as monotherapy for mild Parkinson's, but are not effective for severe Parkinson's. For severe Parksinson's, MAO-B inhibitors are used an an adjunct to levodopa and COMT inhibitors like entecapone and tolcapone. If you want huge increases of dopamine from selegiline, forget about it. It will significantly increase your dopamine over time, but never to the degree of something like cocaine. However, used in combination with levodopa and/or COMT inhibitors, it will boost dopamine massively, comparable to low doses of DRI. But even then, it will take weeks. Nothing will increase your dopamine levels as potently and fast as DRIs like cocaine and methylphenidate, which is why dopamine reuptake inhibitors are so addictive, since the fast and dramatic rise in extracellular dopamine stimulates D2 receptors and triggers the release of endogenous opioids and endocanobinoids in the hedonic hotspots of the brain, giving the rush associated with the high. Nothing that builds up your dopamine stores and doesen't give you a crash will increase your dopamine as fast and dramatically as DRIs. This is why things like selegiline and tolcapone are not considered drugs of abuse. They can raise your dopamine a lot, but not fast enough to give you a high.
As for tyrosine, I suggested tyrosine just to make sure you are getting it. It is abundant in foods, but usually animal protein like eggs and meat, and not everyone gets enough of that. For instance, vegetarians and especially vegans have depressed plasma levels of both tyrosine and l-dopa, and would benefit the most from supplementation. If you eats lots of chicken breasts and eggs, you don't need tyrosine. Tyrosine does not increase central dopamine levels for two reasons. First, the amount of the enzyme, tyrosine hydroxylase, which converts tyrosine into l-dopa, is quite limited. Secondly, the enzyme l-aminoacid decarboxylase breaks down most of the l-dopa outside the brain before it can get there, It is impossible to increase dopamine in the brain by taking tyrosine because so little gets converted into l-dopa and the little that does is mostly broken down outside the brain. With l-dopa it is easier, but without taking a decarboxylase inhibitor like carbidopa, it is still very difficult because it will be mostly broken down before reaching the brain. It is easier to increase dopamine in the brain with l-dopa alone than with tyrosine alone, but still pretty difficult without carbidopa. But at least with l-dopa you have a chance provided you take a huge dose. The dose would need to be roughly 10 X greater than what you would take if you were using a decarboxylase inhibitor. Warning that this dose will produce severe dyskinesia.
My new advice to you is to keep taking the selegiline and be patient, as it will take at least 3 weeks for you to feel the effects. Also, instead of taking tyrosine you can try a Mucuna Pruriens extract which contains l-dopa. Again, without taking a decarboxylase inhibitor together with the l-dopa, it will be very diffcult for the l-dopa to reach your brain. But a small amount of it probably will, and that is better than nothing. You should also seek help from an expert neurologist since using drugs that potently inhibit enzymes in the body has the potential to be very dangerous. Guys go to medical school for 6 years to know what they are doing for a reason...because physiology and pharmacology are difficult, and mistakes can cost lives. Yes, I think insisting on the selegiline and taking a Mucuna Pruriens extract is your best bet. A better bet would be taking the selegiline with pharmaceutical-grade l-dopa and a decarboxylase inhitor. But again, this should be done under a doctor's supervision. Combining selegiline with tolcapone would be immediately even more powerful, but that is something that you should
really only do under the supervision of an expert doctor. The potential for malignant hypertension, and severe damage to the heart and liver is great.
