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Opioids Best Way to Take Oxycodone.......

http://www.ncbi.nlm.nih.gov/m/pubmed/22451244/

METHODS: This was an open, randomized study with two sequences and two visits in 15 elderly patients. The patients were given intravenous injection (over 10 min) of 5 mg of oxycodone hydrochloride trihydrate. Oxycodone hydrochloride (5 mg in all forms) was orally administered as a solution, a capsule, and a controlled-release tablet. Venous blood samples were collected up to 17 h after oxycodone administration. Population PK parameters were calculated with NONMEM VI 2.0. For intravenous injection we calculated clearance, volume of distribution at steady state, and the half-life of elimination, and for oral dosage forms also the absolute bioavailability.

RESULTS: Clearance of the intravenous injections was 28.9 L/h; the volume of distribution at steady state and the half-life of elimination were 186 L and 5.2 h, respectively. The absolute bioavailability of oxycodone was 59 % from oral solutions, 64 % from capsules, and 55 % from controlled-release tablets.

As you can see, the oral bioavailability of oxycodone ranged from 55% to 64% with the various dosage forms.

Surely by now it is clear that oxycodone bioavailability has been overestimated. I believe I have also demonstrated that PO diamorphine and oxycodone are *roughly* equipotent.

Fucking outlandish, eh???
 

Well, thank you for proving that I did NOT say this. I am prescribed 2 30s roxy as needed....currently. At the time of my perc experiment I was much less experienced. My 2 a day roxy did NOT coincide with the time when I could enjoy a single 10mg perc.
 
Sorry, a typo. I meant Tmax, as in the time it takes to reach peak plasma(and therefore peak effects). Tmax of intranasal is 10-20 minutes,vs oral Tmax, which is 1-2h.

As I said, I don't snort pills(or any drugs, for that matter.) But most people I know personally prefer intranasal oxy(though most IV now, unfortunately) and of course, I have snorted plenty of oxy, years ago before I started IV'ing. To me personally, their wasn't a big difference, though intranasal was definatly more euphoric, and much better for DT's, since it hits so much faster.

I consider them (more or less) equal, and they are equal in terms if BA(oral is likely even a little higher) but most seem to prefer intranasal, and I can see why, since I can't imagine not injecting them(on the rare occasions I get them).

But really I am just trying to defend the poor people who snort they're oxy. I mean these people have been told for years that oral is supposedly 1.5-2x as potent, which is insane. They have told than oral oxy has this amazing BA of 60-80%, and that intranasal is like 45%, but anyone who has done them knows it's not. And you have people saying "oral is basically the same as IV", again, not true. The silliest thing is people claiming rectal is comparable to IV, which still cracks me up.(for the record, rectal oxy has an average BA of around 50%, and the Tmax ranges from 2-4h)

So it's just this thing about oxy, having so many misconceptions, when it is quite possibly the most abused opioid in the us(heroin notwithstanding, though at least in my area, oxy is far more prevalent.

But yeah, it was absolutely nothing towards you, I just used your post as a jumping off point!

But the funny part? I don't even like oxy that much! I think it's overrated, and I know that it is overpriced. I have always preferred morphine, even before I tried heroin the first time...


You seem to be keeping real. Usually I always just see "eat it" instead of a response to the question about other ways to take it. It's incredibly frustrating because you're left wondering. or that reason, I am going to ask you about plugging. I get the idea that you're not fond of it, but do you think it works? I want to try it, but I don't want to waste anything.


I tried snorting once and it was a mistake, only because I have allergy issues and my nose is always stuffed up. Snorting made it unbearable. I'm sure if I snorted anything I'd still have those issues, so I'm not blaming the oxy for that.
 
Long time listener, first time caller. And YES I UTFSE and google for a while, but couldn't find discussions that addressed my question.

Anyone here have experience/advice on the best timing of doses when combining oxycontin and oxycodone IR? I've got 20mg OPs and 5mg Oxy IRs. Planning to take at least 20mg IR and 60 ER. And yes, I'm quite opiate tolerant... Just came off the fentanyl 25 patch (which did nothing for my pain or provide any euphoria but sent my tolerance through the roof).

Just looking for advice on timing my doses for best peak effects... Should I take them all at once, or hold off on the IR ones until I start to feel the ER pills kicking in?
 
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