Lorne???
Bluelight Crew
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- May 3, 2014
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http://www.ncbi.nlm.nih.gov/m/pubmed/22451244/
As you can see, the oral bioavailability of oxycodone ranged from 55% to 64% with the various dosage forms.
Surely by now it is clear that oxycodone bioavailability has been overestimated. I believe I have also demonstrated that PO diamorphine and oxycodone are *roughly* equipotent.
Fucking outlandish, eh???
METHODS: This was an open, randomized study with two sequences and two visits in 15 elderly patients. The patients were given intravenous injection (over 10 min) of 5 mg of oxycodone hydrochloride trihydrate. Oxycodone hydrochloride (5 mg in all forms) was orally administered as a solution, a capsule, and a controlled-release tablet. Venous blood samples were collected up to 17 h after oxycodone administration. Population PK parameters were calculated with NONMEM VI 2.0. For intravenous injection we calculated clearance, volume of distribution at steady state, and the half-life of elimination, and for oral dosage forms also the absolute bioavailability.
RESULTS: Clearance of the intravenous injections was 28.9 L/h; the volume of distribution at steady state and the half-life of elimination were 186 L and 5.2 h, respectively. The absolute bioavailability of oxycodone was 59 % from oral solutions, 64 % from capsules, and 55 % from controlled-release tablets.
As you can see, the oral bioavailability of oxycodone ranged from 55% to 64% with the various dosage forms.
Surely by now it is clear that oxycodone bioavailability has been overestimated. I believe I have also demonstrated that PO diamorphine and oxycodone are *roughly* equipotent.
Fucking outlandish, eh???