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Misc Best sleep med

I'm still waiting to read a proper 'trip report on an OX1`/OX2 modulator.

Belsomra (suvorexant)
Quviviq (daridorexant)
Dayvigo (lemborexant)

What immediately strikes me about all three is that they are all are chiral and in each case just one stereoisomer is used. This goes against the practice of 'evergreening' and suggests that the TI if the raecamates might not be favourable.

Several more are in stage 3 trails but many more have been abandoned - which may suggest that the TI IS the issue. One contains deutirium (heavy hydrogen). Now, for a while a lot of pharmacutical companies believed that swapping H for D was another way of evergreening. Then a court made it clear that ONLY IF swapping a H for a D demonstrably improved the medication in question could a patent be obtained.

I know this all sounds very boring, but this is the 99% of drug design that isn't simply drawing a structure.
 
rentedbythehour said:
Has there been any talk of a cpap machine if you have sleep apnea for sure? You may be so groggy because of the lack of oxygen while you're sleeping or constantly waking up. If sleep apnea is your main issue, meds might not help you. A CPAP might be your best option. But only a sleep study would let you know that for sure.

I would be cautious with the meds you said your Dr suggested. Both ambien and temezapam are meant to be short term treatments. Temezapam is only suggested for 7-10 days and ambien 30-90 days. They are really meant to reset your circadian rhythm so you won't need them long term. Seroquel is first and foremost an antipsychotic used to treat things like bipolar and schizophrenia. That would be my last choice out of any med mentioned so far. The side effects wouldn't be worth it. Unless you have an underlying mental health issue, I would take that off the table completely. If you've tried things previously and they're not working now, the best thing might be to see a sleep specialist.
I think the thing that doesn't feel right to me is that your Dr, whom I'm assuming is a general practitioner, would be comfortable prescribing those meds without further testing. I had to see a psychiatrist and neurologist/sleep specialist to be put on the meds I'm taking. Once I was leveled out and not needing any changes, my PCP took over. I'm just looking out for you to be the safest you can be while getting help. I would hate to see you put on meds that either don't help at all, have severe side effects, lead to addiction, or even worse. Suicidal ideation can be a side effect of some of the stuff mentioned and that's not really something that gets talked about when you're prescribed it. You should really educate yourself about what you take and what could happen from it. Just saying....
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Thanks for your input. But idk I’m going to try it and see ! And yes I’ve tried a cpap before but could never get use to it
 
gymguy30 said:
Thanks for your input. But idk I’m going to try it and see ! And yes I’ve tried a cpap before but could never get use to it
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They have news ones out that don't have a mask, no hoses. There's even one that you get inserted during same day procedure that you need nothing else with. If it's been a while it might be worth looking into again.
 
rentedbythehour said:
They have news ones out that don't have a mask, no hoses. There's even one that you get inserted during same day procedure that you need nothing else with. If it's been a while it might be worth looking into again.
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I may look into that but my doc has been practicing medicine for many many many years and he says he has seen the best results with ambien for bad insomnia.
 
gymguy30 said:
I may look into that but my doc has been practicing medicine for many many many years and he says he has seen the best results with ambien for bad insomnia.
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I personally like lunesta better just because it lasts longer. Ambien is good for falling asleep but not really staying asleep. I've been taking lunesta 3mg for a few years now and I've rarely had a night when it didn't work. And I'm a meth user. It still works great.
 
rentedbythehour said:
My Dr switched me lunesta
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I was on Seroquel 400mg and it when I decided to stop taking it, it took around 70 days to be able to sleep again. I was taking Ambien for 70 days and it would not work. Clonidine 0.9mg did not work with the Ambien. Once I got on Lunesta 3mg and took it with Clonidine, I started to sleep again.
 
Them Witches said:
I was on Seroquel 400mg and it when I decided to stop taking it, it took around 70 days to be able to sleep again. I was taking Ambien for 70 days and it would not work. Clonidine 0.9mg did not work with the Ambien. Once I got on Lunesta 3mg and took it with Clonidine, I started to sleep again.
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Lunesta was a godsend when I started it. I have idiopathic hypersomnia so it's either sleep constantly or not at all. Lunesta helped get me back into a routine so regular sleep was actually a thing in my life again.
 
rentedbythehour said:
I personally like lunesta better just because it lasts longer. Ambien is good for falling asleep but not really staying asleep. I've been taking lunesta 3mg for a few years now and I've rarely had a night when it didn't work. And I'm a meth user. It still works great.
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Now that’s saying a lot. I see him in a couple weeks so when he mentions ambian and some other meds I’m going to ask for his opinion on lunesta. Also he was saying last time that he wanted to get me on adderall and feels it would greatly benefit me. When he said that I was thinking (oh yes I believe so too doc big time). Lol 😂 I’ve been prescribed it before but he said all I have to do is fill out some kind of form of some sort and that’s going to basically cover his ass for prescribing it ya know. Also he prescribes me 4mg kpin a day and 24mg Subutex.
 
Yeah you probably have to sign a contract saying you won't use them inappropriately, you'll submit to drug tests, etc. The standard drug contact when you get controlled substances.
 
I did start responding from post#4 in this thread.
After reading through all of what has been said, I think Lunesta is the best option for you.
Even if there's a choice of any medication on the table, I would still choose Zopiclone (Lunesta is close enough for USA).

It is the most reliable sleep medication I have ever taken and have never had to increase the dose to get the desired effect, which is sleep.

In fact sometimes even half the normal dose is perfect too.

Good luck.
 
shreddedlettuce said:
I did start responding from post#4 in this thread.
After reading through all of what has been said, I think Lunesta is the best option for you.
Even if there's a choice of any medication on the table, I would still choose Zopiclone (Lunesta is close enough for USA).

It is the most reliable sleep medication I have ever taken and have never had to increase the dose to get the desired effect, which is sleep.

In fact sometimes even half the normal dose is perfect too.

Good luck.
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I tell ya what man I’m definitely going to mention lunesta to him and see what he thinks. He seems dead set on Ambien being best but I’m sure he would prescribe me the linesta if I ask for it because he’s not an asshole like most docs he actually wants your input provided that you keep it respectful with him.
 
gymguy30 said:
I tell ya what man I’m definitely going to mention lunesta to him and see what he thinks. He seems dead set on Ambien being best but I’m sure he would prescribe me the linesta if I ask for it because he’s not an asshole like most docs he actually wants your input provided that you keep it respectful with him.
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You could try ambien for like 10 days and see if it works, and take it from there. Then you would be able to monitor it according to the benefits you are getting.

Remember, you are looking for the best quality sleep and not a "magic bullet".

Ambien might be perfect for you, only you can be the judge on that.

In this way your doctor would feel more comfortable if this, as it sounds like this is his first line of treatment and you would feel comfortable by trying a sleeping tablet that is the most prescribed in the US.

After trying it out for ten days or so, maybe then ask if you can try Lunesta.

You can then decide after experiencing both, which is best for you.

This is just my opinion though. But am sure your doctor will be amenable to this approach.
 
Zopiclone is the best imo by far. I don't find it recreational at all (maybe in higher doses, havent tried). Actually puts me softly to sleep whereas even at 50mg zolpidem doesn't put me to sleep. 7.5mg of Zopiclone is enough to put me to sleep during and after higher dose dissociative experiences. Haven't tried it for amphetamines but it worked for me for cocaine. It's damn near the perfect sleep med imo. Also doesn't make me drowsy or make it difficult to get out of bed the next day like trazodone or seroquel or even benzos
 
I dont know if, zopiclone bandit is still on bluelight or made a post ? But check thier posts. But i used to be on zopiclone myself and they are great for sleep but i was waking in early hours with bile/vomit in mouth, then falling asleep again so spoke to doctor and they stopped perscibing and gave me diazapeam and i eat a months supply in three to four days and no sleeping other than my usual amount before being on zopiclone
 
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What's the point in taking a GABAergic benzo/Z drug without also blocking adrenaline and glutamate?

The best way blocks stimulating things (adrenaline, cortisol, glutamate) and boosts sedative/inhibitory things (GABA, adenosine, endocannabinoids).

You can't do that with one drug but you can with several OTC ones, without side-effects.
 
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www.drugs.com

Belsomra: Uses, Dosage, Side Effects & Warnings - Drugs.com

Belsomra (suvorexant) is used to treat insomnia. Includes Belsomra side effects, interactions and indications.
www.drugs.com www.drugs.com
I take Belsomra 15 mg with 20 mg melatonin. The Belsomra alone does not give me a full night’s sleep. I tried taking trazodone with Belsomra but that made me groggy during the day.
Sleep is something I cannot do without. I hope you find something that works for you.
 
Just been given poppy heads off a neighbour he said crumble them into a pipe or make a tea from them, but I ain't getting hooked I'm just getting off the crack, still drinking but poppy heads crumbled mean a big NO NO as far as I go!
 
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Lunesta, Clonidine, Ativan, and Vistaril PAM is a great sleep med combo. It should called the "new B-52"...

I just started Busbar and that gives me more energy than normal. I do like what Busbar is doing with Zoloft. They seem to be cousins.
 
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