• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Beating Vivitrol?

btw bupe synergises with qat & pretty much anything dopaminergic. for the flow of dopamine ''opens'' it. i nod the heaven off off a bowl of crack, if i take inuff ritalin i start to nod out instedd of being hyper, & bupe never constricts my pupils until i take something dopaminergic OR take a havevy anticholinergic like 300mg seroquel\ 24perphenazine+ 90mg mirtazapine. everyone i know get pin point eyes from bupe & i stay with huge pupils, i worried maybe theres a lack of edogenous dopamine in my brain or something... it is if a pill of bupe\very slow release ritalin\amp like subuxone but bupe+ D agent needed for me.
 
Last edited:
It seems to be the case that clomethiazole is legal everywhere but it IS a prescription drug and as LC pointed out - it is very dangerous. The few studies suggest that it acts in a similar manner to other picotoxin/barbiturate site ligands. Very good if you are organized and resolute but it has killed a lot of people. I rewrote the McDermott Guide to sedative drugs so it has been well covered. The only fault in the booklet is that diconal does not contain silica and hasn't for almost 40 years. That doesn't alter much but the old wives tale of veinous damage is no different than that caused by injecting any pill.

As for naltrexone, it's a risky venture to try to overcome the blockade and it seems people's reaction to buprenorphine differs. For some it seems to overcome the antagonist, in others it only makes matters worse which is why a specialist is the only person who may script them for hyperaglasia. Messing with the stuff on the black market with sufficient affinity will just see you ending up dead. I'm sure we are all aware of the class I'm alluding to but if it's stay clean or go to jail - I would seriously consider staying clean. Incarceration or death is the likely outcome. That's why Casey's acid helps. It helped me in any case. Proper sugar cubes.
 
asecin said:
im surprised you guys never mixed alcohol with opiates. its pretty damn nice, but maybe dangerous if you overdo it. thats why carrying narcan spray is recommended, as thats what i do.
Click to expand...
You guessed wrong.

I've been detoxed from alcohol using all three benzos commonly used for that purpose and none of them are going to make you feel like a million bucks (Clubcard-the doses you were getting are a joke. I got 50mg walking in the door). The really lucky folks got detoxed using phenobarbital but that's rare anymore because there is no specific antidote to barbiturate overdose. Benzo overdose can be quickly reversed with flumenzanil.
 
What about bemegride, and nikethamide? are either still used? because they used to be for barbiturate overdose.

There was a doctor convicted a long time ago for murder, forget his name, because he gave a woman who'd OD'ed on barbiturates one dose of bemegride, and no more. She died. Something Adams, IIRC his name was, although the memory of his name is hazy.

And CC-AFAIK you are right about chlor/bromethiazole. They are barb/picrotoxin site agonists. Both of them feel, subjectively, more like barbiturates than they do like benzos. Although barbiturates have an additional danger factor compared to chlormethiazole/bromethiazole. AMPA receptor antagonism. Making them both GABAa activators, and antiglutamatergics, ergo, enhancing inhibitory neurotransmission and depressing excitatory neurotransmission. A double-barreled depressant blast.

I found barbs to be VERY 'anti-nootropic', extremely amnestic, whilst chlormethizole and bromethiazole are very clear-headed to me. (and I've a lot of experience, although mainly with the chlorinated original, only had bromethiazole a handful of doses. But seems to be similarly clean. Pretty sure it isn't in clinical use though. But I'd hazard a guess that it too, would be pretty good at wiping people out in overdose.

Still, either of them would be my favourite GABAergic depressants, at least, of any I've experienced.
 
I guess this is off topic because it?s not technically beating Vivitrol, but I?ve been on the shot for 7months because of a court ordered program after a simple cannabis possession charge. I?m scheduled for surgery next week and I?m 47 days post injection. My doctor gave me Percocet 15s for pain management before the surgery and so far I have had no pain relief whatsoever. How long does the blocker stick around? I?ve heard 2-3 months after the last injection. I don?t want to try to overcome the vivitrol because I?m relatively inexperienced with opiates as it is and OD is a real possibility. I don?t want to tell my surgeron about the Vivitrol I get anything special because I live in WV and that would certainly red flag me and stop me from getting proper pain management in the future. Quite ridiculous and unnecessary I think for a pot charge. Just in a a lot of pain and need relief.
 
Limpet_Chicken said:
What about bemegride, and nikethamide? are either still used? because they used to be for barbiturate overdose.
Click to expand...
No - bemegride comes with its own hazards since it induces convulsions and nikethamide has been rendered irrelevant by endotracheal intubation. Current medical protocol for barbiturate OD is gastric lavage, dialysis and endotracheal intubation. It's understandable that barbs have been largely superseded in current medical practice because administering IV Flumazenil is a lot less trouble than the last three procedures combined.

Jamrock00 said:
I guess this is off topic because it?s not technically beating Vivitrol, but I?ve been on the shot for 7months because of a court ordered program after a simple cannabis possession charge. I?m scheduled for surgery next week and I?m 47 days post injection. My doctor gave me Percocet 15s for pain management before the surgery and so far I have had no pain relief whatsoever. How long does the blocker stick around? I?ve heard 2-3 months after the last injection. I don?t want to try to overcome the vivitrol because I?m relatively inexperienced with opiates as it is and OD is a real possibility. I don?t want to tell my surgeron about the Vivitrol I get anything special because I live in WV and that would certainly red flag me and stop me from getting proper pain management in the future. Quite ridiculous and unnecessary I think for a pot charge. Just in a a lot of pain and need relief.
Click to expand...

Seven shots is a lot of Vivitrol and it will take a few months to wear off. I don't blame you, especially living in West Virginia for not wanting to tell your doctor. You sound level headed because overcoming the blocker almost guarantees OD. Is there any way of steering a conversation with your doctor around alternatives like Neurontin or Lyrica without explaining why? And WV is a medical weed state. Any possibility of that?
 
Last edited:
Well to my knowledge the medical laws go into effect in 2019 and are ridiculously strict and don?t include smokeable or edible products. I had a medical card in Cali and Colorado before moving here for other chronic issues like seizures and migraines but was told those wouldn?t qualify me in this state. If i wasn?t on probation being drug tested 2-3 times a week I would?ve made my own oil and been taking it in capsule form already. I did mention other options to my doctor but what I?m going through (gall stones and gallbladder removal) makes me ineligible for a chronic pain medication. I had a gall stone attack last year and the only thing that helped was the Iv dilaudid they gave me at the Er and the pain meds they prescribed for short term use. It?s very frustrating not being able to get relief. I hope I don?t have to wait too much longer but I refuse to go through surgery without effective aftercare. I have a kid and work 2 jobs and there?s no way I can handle this kind of pain for another 2-3 months. It?s a very unfortunate situation.
 
For a weed charge? fucking hell, being forced on to vivitrol? thats abhorrent!

You'll need to explainit to the anaesthetist, in context.

That's damn dangerous, forcing anyone onto something like that. What's going to happen when some poor bastard is forced onto that and then ends up in a car wreck, pulped beyond recognition as a human being, but still not able to die? with no painkillers whatsoever because they won't work? I hope it doesn't happen, but at the same time if and IMO, WHEN it does, I really hope patients sue the fuck out of the bastards responsible for pushing this filth.
 
The program I?m in is called Day Report which has only been around maybe 3-4 years in WV. Basically you go there 3-4 sometimes 5 times a week for classes and call in for random drug testing every day. They?re filtering all the non violent drug offenders into it in lieu of jail and while they?re on bond. Almost everyone there has to get the shot no matter what the charge is. It?s a great insurance scam. The 30$ drug store drug tests alone net 1500 in insurance reimbursemt. CAn timagine what they get for a 1900$ shot every month for 90% of their clients. I know if you?re injured or have emergency suregery and you tell them you?re on it a specialist will come in and administer some kind of specialized pain medication but that?s a lot to go through so a state program can rape your insurance and Medicaid.
 
Limpet_Chicken said:
That's damn dangerous, forcing anyone onto something like that. What's going to happen when some poor bastard is forced onto that and then ends up in a car wreck, pulped beyond recognition as a human being, but still not able to die? with no painkillers whatsoever because they won't work? I hope it doesn't happen, but at the same time if and IMO, WHEN it does, I really hope patients sue the fuck out of the bastards responsible for pushing this filth.
Click to expand...

Its 8th Amendment and coercive medical treatment without consent but who you gonna sue? where you gonna sue them, in the WV courts who are running this scheme? Welcome to the prison industrial complex USA. USA the shining city on the Hill.

For we must consider that we shall be as a city upon a hill, the eyes of all people are upon us; so that if we shall deal falsely with our God in this work we have undertaken, and so cause Him to withdraw His present help from us, we shall shame the faces of many of God's worthy servants, and cause their prayers to be turned into curses.
 
Last edited:
Limpet_Chicken said:
What's going to happen when some poor bastard is forced onto that and then ends up in a car wreck, pulped beyond recognition as a human being, but still not able to die? with no painkillers whatsoever because they won't work?
Click to expand...
It was recommended to the people on Vivitrol at my rehab that they carry some kind of bracelet or card on them for these kinds of situations. Basically all you can do in those situations is get a local anesthetic, gabapentin or pregabalin, or even more laughably, a NSAID pain reliever. Another reason I told the rehab where to stick it when the doctor pushed the shot to me. I told them I would walk before I got the shot and they backed down. I read somewhere there is a short-acting fentanyl analogue that can be used in clinical settings, but it can only be administered as an IV drip.

I always say I'll be the one suing under those circumstances, but yeah, I'd probably get the shot too before I let them let me rot in jail.
 
The worst prt about this particular program I?m in is that people who are on suboxone or methadone are forced to give that up and get the shot instead. ?No mood or mind altering substances.? That includes all prescription medication for people with anxiety or chronic pain, again regardless of the charge that got you there. There?s one guy who got a domestic assault charge who happened to be drunk and they made him get it too. A girl with lupus and rheumatoid arthritis got sent back to jail for taking her pain medication. Another girl went to jail because they wouldn?t let her continue her suboxone and she knew she could at least buy it in jail. Before I got my first shot I needed 2 route canals and had to wait a week to get it done and they tested me every day to make sure I wasn?t taking the pain meds I was prescribed. Now I have to wait however many months for the blocker to wear off and it?s all such bullshit. Still technically not allowed to take meds for the surgery but fuck that, I?m gonna ask my lawyer about it.
 
^ This sounds actionable. I'm shocked I haven't heard of any states requiring it for DUI offenders if they made the drunk guy with the DV charge get it. It would be a major cash cow for Alkermes.
 
For real. Why spend money improving our treatment centers, outreach programs and mental health care when we can make money putting a bandaid on a bullet wound. Removing the option to get high gives you time to work on the internal and environmental issues that have a hand in addiction. The problem is a lot of addicts return to using as soon as they can and overdose and die at the worst and resume an all consuming habit at best. You cant force people to change. You can?t make medical decisions for them under threat of jail and provide little to know treatment in the meantime.
 
i wonder if ketamine can substitute the use of vivitrol for such addiction problems. too bad its outrageously priced and not pushed by any pharm on anyone for anything really
 
aihfl said:
It was recommended to the people on Vivitrol at my rehab that they carry some kind of bracelet or card on them for these kinds of situations. Basically all you can do in those situations is get a local anesthetic, gabapentin or pregabalin, or even more laughably, a NSAID pain reliever. Another reason I told the rehab where to stick it when the doctor pushed the shot to me. I told them I would walk before I got the shot and they backed down. I read somewhere there is a short-acting fentanyl analogue that can be used in clinical settings, but it can only be administered as an IV drip.

I always say I'll be the one suing under those circumstances, but yeah, I'd probably get the shot too before I let them let me rot in jail.
Click to expand...

Sufentanil has been used in this manner.

Naltrexone makes a great precursor for oxymorphine. That will fuck them over. We provide medication that now has a street value....

HR by any means.
 
Or perhaps more interesting, iodobenzoylnaltrexamide, it's a biased agonist that doesn't recruit beta-arrestin II.

As for using NMDA antagonists to detox, I'm absolutely certain of it, it'll do the trick. Memantine, in my experience completely stripped opioids (oxycodone, morphine, dipropionyl/dibenzoyl/dibutyrylmorphine) of reinforcing properties. And I've used MXE, 3-MeO/3-OH/4-MeO-PCP to kill withdrawals, same goes for diphenidine/methoxphenidine.
 
Limpet_Chicken said:
Or perhaps more interesting, iodobenzoylnaltrexamide, it's a biased agonist that doesn't recruit beta-arrestin II.

As for using NMDA antagonists to detox, I'm absolutely certain of it, it'll do the trick. Memantine, in my experience completely stripped opioids (oxycodone, morphine, dipropionyl/dibenzoyl/dibutyrylmorphine) of reinforcing properties. And I've used MXE, 3-MeO/3-OH/4-MeO-PCP to kill withdrawals, same goes for diphenidine/methoxphenidine.
Click to expand...

Interesting but an utterly unrealistic target. CH3I followed by sodium thiophenolate is realistic. sekio conveniently linked to the paper. Take any antagonist.... BTW Drone342 (Joe) recommended ethanolamine. Your entire lab will stink of fish and the smell clings for MONTHS. A classic 'looks good on the page' route. High MP reagents ONLY!


Suddenly dozens of realistic precursors BUT nobody gets a bigger budget to watch them all. At what point does control become impossible? Items of commerce.
 
Last edited:
You must log in or register to reply here.
Top