Organic chemistry & Pharmacology
I have been researching compounds and reading in-depth medical journals and scientific research papers conducted by professional pharmaceutical researchers. Nothing I say or learn is anacdotal b.s. or here say someone tells me
Google is your best friend …..and don’t underestimate Wikipedia (really lol) it’s VERY informative and extremely accurate/correct in all data posted about the compound/topic
I will google for say….. Methylphenidate (Ritalin) and co-ingestion of Ethanol (Alcohol) in human subjects medical studies / medical journal etc……and will be available several papers, all with same finding …..ethanol increases the dextro-threo-methylphenidate (Focalin) by 40% …..SIGNIFICANTLY enhancing the euphoric subjective effects in all study participants . Reports of Stimulated, feels good, energetic, happy, high, etc were all reported by study participants. Therefor Ethanol (Alcohol) when co-ingested with Ritalin (Methylphenidate) increases the active stereo isomer of the molecule
(Methylphenidate) actually has 4 stereo isomers, since the molecule has two chiral centres…….2 sets of Threo (dextro & Levo) and 2 sets of Erythro (dextro & Levo) ……from which primarily d-threo-methylphenidate exhibits the pharmacological desired effects. it was found that only the Threo isomers had activity at inhibiting the monoamines (DAT & NET) Dopamine transporter (which was brought to market by CIBA Pharmaceuticals under the trade name RITALIN …..yet it was further discovered that only the d-threo-MPH isomer was responsible for DAT/NET inhibition ….and this was brought to market under the trade name FOCALIN. Focalin is often used as an example as an “over engineered drug”
Ritalin 20mg
Focalin 10mg …..both compounds/doses have identical properties at the DAT & NET
Also, Ritalin (Methylphenidate) isn’t your typical DNRI ….its actually classified as an Inverse Agonist, EXTREMELY similar and nearly identical to Cocaine HCL in its MOA….binding to the monoamine transporters (preventing their reuptake) and indirectly causing the release of Dopamine, Norepinephrine, and Serotonin (only Cocaine has SERT activity)
Ritalin (Methylphenidate) is considered a “Classic Amphetamine” and a highly respected/regarded Dopaminergic Stimulant. In my entire lifetime, me personally…..the only 2 drugs to ever give me true euphoria, was oral Oxycodone & Ritalin. An overwhelming sense of wellbeing, overly happy & giddy, stimulated, talkative, social butterfly, confident, outgoing and euphoric bliss…..both Ritalin & Oxycodone alike. Nearly identical in the euphoric pleasure it induced in my CNS …..wow. Both drugs taken at once….with several mixed drinks, would be like shooting a Speedball lol. Literally. ……the following all TRUE dopaminergic stimulant compounds capable of inducing profound euphoria, robust mood-boosting properties, increased vigilance, strength, stamina, libido, etc
Methylphenidate (Ritalin)
Phenmetrazine (Preludin)
Cocaine (Illicit)
Amphetamine (Benzedrine)
d-Amphetamine (Dexedrine/Adderall)
Methamphetamine (Desoxyn/Methedrine)
I basically educated myself over 10-15 years of reading medical journals and scientific research papers …..if 3 separate sources all come to the same results about testing a compound, as an example…I’m confident in the validity of the results and trust the data. I just found everything extremely interesting and would sometimes spend an entire day reading medical journals and research papers about certain compounds
Type in any drug…..and specify, medical journal or scientific research papers and alike …..you’ll know when you’ve found them
In regards to Avizafone (Pro-Diazepam) it’s a water soluble pro-drug (just like Vyvanse - Lisdexamfetamine) once orally ingested it enters the stomach, large/small intestine (GI track) were it enters the bloodstream. Once in the bloodstream the parent molecule is metabolized into its API (active pharmaceutical ingredient) were the Lysine amino acid is cleaved resulting in active Diazepam (Valium) …..or in Vyvanse case, the active d-Amphetamine
Avizafone has several medical journals online, and one pharmaceutical company has it advertised on its main website, directing its use to hospitals whom deal with aggressive & violent patients whom need to be RAPIDLY sedated. An IM injection of Valium, Ativan or Midazolam would take 20min + for onset/taking effect, which is waaaay too long. Medical staff receive serious injuries, are violently assaulted, punched, kicked, etc ….Avizafone (Pro-Diazepam) is a rapid acting, water soluble form of Valium (Diazepam) which takes effect in 5-10min while being safely restrained by hospital staff.
I’m just fascinated by this magic in medicine lol, organic chemistry & pharmacology are Soooooo freaking cool and interesting. Also is amazing I have complete access to all of these compounds . Canada

is Amazing for RC chems and online Psilocybin, LSD, Cannabis, DMT, Ketamine, MDMA,
Mephedrone (4-MMC) 4-Methyl-MethCathinone which causes a 950% increase sin Serotonin and a 500% increase in Dopamine ….a very euphoric stimulant similar to Amphetamines, MDMA, and Cocaine. Study participants found Mephedrone more euphoric/pleasurable than Cocaine (which is often weak cut shit, adulterated with inert filler)
Just google it and find professional pharmaceutical medical research studies / medical journals