Benzos Avizafone & Rilmazafone

[daturetard]

Yes, I believe so.

it was invented for an antidote for biological weapons/warfare as a 3 part auto-injector pen, containing Atrophine, Avizafone, and another substance

pralidoxime

 

[DaiBanto]

Isn’t it more satisfying doing your own research, you don’t feel a total asshole, and you aren’t being led astray by a genuine asshole who may be giving you erroneous and possibly deadly misinformation. Good research. Be safe.

Besides bromaz I haven’t found many that would be seem to be good. Simply asking your preference. I had etiz once and I guess it was alright just sorta knocked me out though

Etizolam is generally dissolved in PG or alcohol, I believe.

 

[steewith2ees]

Lorazepam is water soluble and is the only bzd derivative I have ever come across in general medicine that can be given IM. Most others have to be either oral, mucus membrane or IV inc. diazepam. IM is not suitable due to erratic absorption.

 

[DaiBanto]

You wrote a informative post about how avivazone was developed as a water soluble pro-drug that the body converts into diazepam (actually you may have omitted that it was a PRO-drug, like vyvanse). Um…it’s true that I omitted the other drugs in the cock

Besides bromaz I haven’t found many that would be seem to be good. Simply asking your preference. I had etiz once and I guess it was alright just sorta knocked me out though

etizolam isn’t water soluble as far as I’m aware. I’ve seen solutions in PG and made my own with ethanol (vodka). Dalmane (forgot the generic name ) capsule’s contents appear to dissolve in hot water-no rush that I recall though.

 

[DaiBanto]

Isn’t it more satisfying doing your own research, you don’t feel a total asshole, and you aren’t being led astray by a genuine asshole who may be giving you erroneous and possibly deadly misinformation. Good research. Be safe.

Etizolam is generally dissolved in PG or alcohol, I believe.

By the way ‘do your own research’ was an anti vaccine Covid era catchphrase I used as a joke-that fell flat.

 

[Trippytamine]

I agree there would me dependence bc once it passed through the intestines it becomes active BZO and therefore subsequent tolerance and dependence.
What I remember from reading it before was it was a very mild “cloak over concerns and worries” I had. Nothing recreational or feel good about it….just minor anxiolytic and helpful for insomnia.
My newest frustration is I have a big pile of books of Rilm, but not prepared. I’ve not had chemistry in decades so I’m trying to figure out what to do with the this big pile. I know eyeball estimates are never a good ideas at the mg level. Maybe a solid mg scale but still that like: “Here have what about 5-10 grains of sand, right?!”
Not the most pleasant way to enjoy getting into some mild reading materials, ya know.

Late reply I know- but if memory serves me right (don't quote me on this), Rilmazafone is water soluble. So creating a simple volumetrically-dosed solution with distilled water should work.

 

[username_required]

Just took about 15-30mg orally dissolved in water (my scale isn’t super accurate at low doses so I don’t have an exact dose) and it is definitely working. Can confirm that the dumbass on the first page on a crusade about Avizafone being IM only is completely wrong. I will try insufflation later and report back.

 

[emkee_reinvented]

How do you find deschloroetizolam? It is more easily available now than etiz. I find it a useful benzo, if not the very best.

Seems about the same but as it ime has a slower comeup and decline I hardly notice it unlike Etizolam.

Never went overboard but it to me feels ok. The same well its not so in your face thats for sure.
If it resembles the parent I actually wonder as it was so long ago banned.

 

[bunny22]

@Dextro .45 how do you know so much and have you synthesise any RC yourself?
I know you can't know everything overnight but would you be kind enough to share some books or lectures or whatever so I can also learn this stuff?
I don't even know where it fits? Organic chemistry?
@username_required you have taken Avizafone orally? Please let us know how it goes

 

[Dextro .45]

Organic chemistry & Pharmacology

I have been researching compounds and reading in-depth medical journals and scientific research papers conducted by professional pharmaceutical researchers. Nothing I say or learn is anacdotal b.s. or here say someone tells me

Google is your best friend …..and don’t underestimate Wikipedia (really lol) it’s VERY informative and extremely accurate/correct in all data posted about the compound/topic

I will google for say….. Methylphenidate (Ritalin) and co-ingestion of Ethanol (Alcohol) in human subjects medical studies / medical journal etc……and will be available several papers, all with same finding …..ethanol increases the dextro-threo-methylphenidate (Focalin) by 40% …..SIGNIFICANTLY enhancing the euphoric subjective effects in all study participants . Reports of Stimulated, feels good, energetic, happy, high, etc were all reported by study participants. Therefor Ethanol (Alcohol) when co-ingested with Ritalin (Methylphenidate) increases the active stereo isomer of the molecule

(Methylphenidate) actually has 4 stereo isomers, since the molecule has two chiral centres…….2 sets of Threo (dextro & Levo) and 2 sets of Erythro (dextro & Levo) ……from which primarily d-threo-methylphenidate exhibits the pharmacological desired effects. it was found that only the Threo isomers had activity at inhibiting the monoamines (DAT & NET) Dopamine transporter (which was brought to market by CIBA Pharmaceuticals under the trade name RITALIN …..yet it was further discovered that only the d-threo-MPH isomer was responsible for DAT/NET inhibition ….and this was brought to market under the trade name FOCALIN. Focalin is often used as an example as an “over engineered drug”

Ritalin 20mg
Focalin 10mg …..both compounds/doses have identical properties at the DAT & NET

Also, Ritalin (Methylphenidate) isn’t your typical DNRI ….its actually classified as an Inverse Agonist, EXTREMELY similar and nearly identical to Cocaine HCL in its MOA….binding to the monoamine transporters (preventing their reuptake) and indirectly causing the release of Dopamine, Norepinephrine, and Serotonin (only Cocaine has SERT activity)

Ritalin (Methylphenidate) is considered a “Classic Amphetamine” and a highly respected/regarded Dopaminergic Stimulant. In my entire lifetime, me personally…..the only 2 drugs to ever give me true euphoria, was oral Oxycodone & Ritalin. An overwhelming sense of wellbeing, overly happy & giddy, stimulated, talkative, social butterfly, confident, outgoing and euphoric bliss…..both Ritalin & Oxycodone alike. Nearly identical in the euphoric pleasure it induced in my CNS …..wow. Both drugs taken at once….with several mixed drinks, would be like shooting a Speedball lol. Literally. ……the following all TRUE dopaminergic stimulant compounds capable of inducing profound euphoria, robust mood-boosting properties, increased vigilance, strength, stamina, libido, etc

Methylphenidate (Ritalin)
Phenmetrazine (Preludin)
Cocaine (Illicit)
Amphetamine (Benzedrine)
d-Amphetamine (Dexedrine/Adderall)
Methamphetamine (Desoxyn/Methedrine)

I basically educated myself over 10-15 years of reading medical journals and scientific research papers …..if 3 separate sources all come to the same results about testing a compound, as an example…I’m confident in the validity of the results and trust the data. I just found everything extremely interesting and would sometimes spend an entire day reading medical journals and research papers about certain compounds

Type in any drug…..and specify, medical journal or scientific research papers and alike …..you’ll know when you’ve found them

In regards to Avizafone (Pro-Diazepam) it’s a water soluble pro-drug (just like Vyvanse - Lisdexamfetamine) once orally ingested it enters the stomach, large/small intestine (GI track) were it enters the bloodstream. Once in the bloodstream the parent molecule is metabolized into its API (active pharmaceutical ingredient) were the Lysine amino acid is cleaved resulting in active Diazepam (Valium) …..or in Vyvanse case, the active d-Amphetamine

Avizafone has several medical journals online, and one pharmaceutical company has it advertised on its main website, directing its use to hospitals whom deal with aggressive & violent patients whom need to be RAPIDLY sedated. An IM injection of Valium, Ativan or Midazolam would take 20min + for onset/taking effect, which is waaaay too long. Medical staff receive serious injuries, are violently assaulted, punched, kicked, etc ….Avizafone (Pro-Diazepam) is a rapid acting, water soluble form of Valium (Diazepam) which takes effect in 5-10min while being safely restrained by hospital staff.

I’m just fascinated by this magic in medicine lol, organic chemistry & pharmacology are Soooooo freaking cool and interesting. Also is amazing I have complete access to all of these compounds . Canada is Amazing for RC chems and online Psilocybin, LSD, Cannabis, DMT, Ketamine, MDMA,

Mephedrone (4-MMC) 4-Methyl-MethCathinone which causes a 950% increase sin Serotonin and a 500% increase in Dopamine ….a very euphoric stimulant similar to Amphetamines, MDMA, and Cocaine. Study participants found Mephedrone more euphoric/pleasurable than Cocaine (which is often weak cut shit, adulterated with inert filler)

Just google it and find professional pharmaceutical medical research studies / medical journals

 

[Dextro .45]

@Dextro .45 how do you know so much and have you synthesise any RC yourself?
I know you can't know everything overnight but would you be kind enough to share some books or lectures or whatever so I can also learn this stuff?
I don't even know where it fits? Organic chemistry?
@username_required you have taken Avizafone orally? Please let us know how it goes

You can take Avizafone (Pro-Diazepam) orally indeed. In hospital setting it is administered via IM injection, but you can / I would take it orally. You can buy a digital scale online for $20-30 bucks and are very accurate

Avizafone 20mg
Diazepam 11.5mg

 

[Dextro .45]

You wrote a informative post about how avivazafone was developed as a water soluble pro-drug that the body converts into diazepam (actually you may have omitted that it was a PRO-drug, like vyvanse) as part of the treatment for some forms of nervegas. One wonders why Big Pharma didn’t use one of the powerful water soluble benzos they already have languishing on their shelves. But I’m much too stupid to answer that question.
Um…it’s true that I omitted the other drugs in the cocktail of the antidote

Actually, a pharmaceutical company is marketing and selling Avizafone (Pro-Diazepam) to the hospital industry & private clinics. It’s on their main website

For violent & aggressive patients that need to be rapidly sedated an IM benzodiazepine is used, either Valium or Midazolam ….which takes 30min to take full effect ….which is waaaay too long when a meth addict is assaulting hospital staff, yelling while being restrained…..NOW, with the rapid acting, water soluble pro-drug Avizafone (Pro-Diazepam) the IM injection takes effect rapidly in 5-10min. Amazing.

I have access to several vendors that have Avizafone….basically a rapid acting pharmaceutical grade Valium. Dosed as such… so 60-80mg of Avizafone would be approximately 3-4 tablets of baby blues lol Valium 10mg ….standard dose for a 240lbs 6’ man

Avizafone 20mg
Diazepam 11.5mg

Yes, it’s essentially the same technology as Vyvanse (Lisdexamfetamine) which is a pro-drug that metabolizes into the API Dextro-Amphetamine. Like Avizafone & Vyvanse once introduced into the bloodstream the Lysine amino acid entity is cleaved from the molecule leaving the active pharmaceutical ingredient…..Diazepam (Valium)

 

[Trippytamine]

Nasal Avizafone is super strong too! A nasal spray is overpowered lol

 

[username_required]

@Dextro .45 how do you know so much and have you synthesise any RC yourself?
I know you can't know everything overnight but would you be kind enough to share some books or lectures or whatever so I can also learn this stuff?
I don't even know where it fits? Organic chemistry?
@username_required you have taken Avizafone orally? Please let us know how it goes

Went pretty much as I expected. I’m fairly new to Benozos and I’ve never tried actual
valium so I can’t make a comparison but it was definitely orally active and made me feel very relaxed. According to my girlfriend I took a fall and broke a laundry basket lmfao but I have no recollection of that happening and I am thankfully uninjured. I have a physical dependence on Clonidine to sleep so benzos don’t make me tired or fall asleep whatsoever so my experience is probably a little different than most. Overall 10/10 experience it is definitely orally active

edit: also i’d like to add that the stuff was in powered form and is extremely sticky for some reason? has anyone else experienced this before?

 

[Dextro .45]

Went pretty much as I expected. I’m fairly new to Benozos and I’ve never tried actual
valium so I can’t make a comparison but it was definitely orally active and made me feel very relaxed. According to my girlfriend I took a fall and broke a laundry basket lmfao but I have no recollection of that happening and I am thankfully uninjured. I have a physical dependence on Clonidine to sleep so benzos don’t make me tired or fall asleep whatsoever so my experience is probably a little different than most. Overall 10/10 experience it is definitely orally active

edit: also i’d like to add that the stuff was in powered form and is extremely sticky for some reason? has anyone else experienced this before?

Where are you located? In Canada …U.S. ? Just curious if it was from a vendor I know. Don’t list the vendor. Not allowed …did you weigh out your Avizafone dosage? ….any details ?

Empty stomach/or full meal
Onset of action taken orally……30min?
A gradual onset I’m assuming …. Avizafone 20mg = Diazepam 11.5mg

You’re on Clonidine nightly? Be sure to gradually reduce your dose before ending or just do it anyway…..

 

[username_required]

Where are you located? In Canada …U.S. ? Just curious if it was from a vendor I know. Don’t list the vendor. Not allowed …did you weigh out your Avizafone dosage? ….any details ?

Empty stomach/or full meal
Onset of action taken orally……30min?
A gradual onset I’m assuming …. Avizafone 20mg = Diazepam 11.5mg

You’re on Clonidine nightly? Be sure to gradually reduce your dose before ending or just do it anyway…..

Located in Canada. Approx 160lbs. Tried weighing out the dose but my aliexpress scale couldn’t measure the doses I was taking but was going for roughly 20mg. I think it’s about 20-30 minutes for it to begin working but it’s hard to say because of my inexperience. Can’t recall how much I had eaten but I’m about to have some and I’ve just had some Trailer Park Boys chips (highly recommend if you live in Canada that you try them) and a chicken breast.
I also have no plans to discontinue my clonidine as I find it unbelievably helpful for my insomnia and I can still take psychedelics unlike on antipsychotics and the like.
I would probably try and snort it at some point but like i said the power is extremely sticky so i don’t think it would actually make into my nose lol.

 

[Dextro .45]

Oh ya....Clonidine is AMAZINGLY effective for insomnia sleep issues, also a VERY effective & potent anxiolytic medication that can match Valium at eliminating stress, worry, anxiety

I just placed an order for Avizafone 1 gram last night.....etransfer already accepted, hopefully it's in my mailbox by Friday. I'll leave a detailed report on everything. I'm 240lbs 6' male and usually take 2-3 Valium 10mg tablets.....so I'll probably take 40-50mg of Avizafone (after an initial 5-10mg safety test and wait an hour)

I also ordered a gram of Mephedrone 4-MMC which will arrive tomorrow XpressPost

 

[Dextro .45]

Located in Canada. Approx 160lbs. Tried weighing out the dose but my aliexpress scale couldn’t measure the doses I was taking but was going for roughly 20mg. I think it’s about 20-30 minutes for it to begin working but it’s hard to say because of my inexperience. Can’t recall how much I had eaten but I’m about to have some and I’ve just had some Trailer Park Boys chips (highly recommend if you live in Canada that you try them) and a chicken breast.
I also have no plans to discontinue my clonidine as I find it unbelievably helpful for my insomnia and I can still take psychedelics unlike on antipsychotics and the like.
I would probably try and snort it at some point but like i said the power is extremely sticky so i don’t think it would actually make into my nose lol.

Also, you're in Canada .....without telling vendor or price.....there are 2 vendors who offer Avizafone.....for 1 g one vendor has 20-30 items listed while the other has 7 to 10 listed

 

[username_required]

Also, you're in Canada .....without telling vendor or price.....there are 2 vendors who offer Avizafone.....for 1 g one vendor has 20-30 items listed while the other has 7 to 10 listed

The one I purchased from also has MDPM and Allylescaline for sale and is currently having an August sale site wide and Avizafone is 30% off at the moment. I didn’t realize there was another source for Avizafone in Canada other than the one I purchase from.

I’ve just ordered 25 tabs of 1p-LSD over lettermail from them and I’ve never ordered anything from lettermail but I do live extremely close by to them so hopefully it’s shorter than the 1-2 week estimate on the order page.

 

[username_required]

Oh ya....Clonidine is AMAZINGLY effective for insomnia sleep issues, also a VERY effective & potent anxiolytic medication that can match Valium at eliminating stress, worry, anxiety

I just placed an order for Avizafone 1 gram last night.....etransfer already accepted, hopefully it's in my mailbox by Friday. I'll leave a detailed report on everything. I'm 240lbs 6' male and usually take 2-3 Valium 10mg tablets.....so I'll probably take 40-50mg of Avizafone (after an initial 5-10mg safety test and wait an hour)

I also ordered a gram of Mephedrone 4-MMC which will arrive tomorrow XpressPost

It makes me pretty mad that I had to specifically research and ask for clonidine on my own to get a prescription for it considering how awful the side effect profiles are of traditional antipsychotics and how commonly they prescribe those first. Unluckily for me I’m a CYP2D6 rapid metabolizer so the anxiolytic effects aren’t as strong during the day as I imagine they are for most people. I’m also prescribed 1000ug for my insomnia lol which is nuts considering my girlfriend will pass out for 12 hours with just 100ug.