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Benzos Avizafone & Rilmazafone

I've taken and been depeden on rilmazafone. You cannot black out on it and it has minimal anxiety relief
 
I agree there would me dependence bc once it passed through the intestines it becomes active BZO and therefore subsequent tolerance and dependence.
What I remember from reading it before was it was a very mild “cloak over concerns and worries” I had. Nothing recreational or feel good about it….just minor anxiolytic and helpful for insomnia.
My newest frustration is I have a big pile of books of Rilm, but not prepared. I’ve not had chemistry in decades so I’m trying to figure out what to do with the this big pile. I know eyeball estimates are never a good ideas at the mg level. Maybe a solid mg scale but still that like: “Here have what about 5-10 grains of sand, right?!”
Not the most pleasant way to enjoy getting into some mild reading materials, ya know.
 
I thought I had read Avizofone was administered IV as a nerve gas ‘antidote’. But it seems that’s wrong. It is available but prohibitively expensive.
 
Dextro .45 said:
Yes, I believe so.

it was invented for an antidote for biological weapons/warfare as a 3 part auto-injector pen, containing Atrophine, Avizafone, and another substance

they needed a water soluable, rapid acting form of Diazepam (Valium) and so the pro-drug Avizafone (Pro-Diazepam) was synthesized

Im interested in trying it ….but again, much rather have Valium 10’s. My current benzodiazepines

1) 2-Chloro-Diazepam
Diclazepam > Delorazepam > Lorazepam (Ativan)

2) Diazepam (Valium)

3) Avizafone (Pro-Diazepam)

4) Etizolam & Deschloroetizolam
Click to expand...
How do you find deschloroetizolam? It is more easily available now than etiz. I find it a useful benzo, if not the very best.
 
Yes, Deschloroetizolam is AMAZING …I’ve always loved it. Actually more pleasurable & euphoric than Etizolam. Slightly less potent and longer duration of action

Etizolam 1mg
Deschloroetizolam 4-6mg

Deschloroetizolam is like the Xanax (Anxiolytic & Antidepressant) to Triazolam (Hypnotic/Sedative) “Etizolam“ (which Etizolam isn’t btw, it’s also an uplifting Anxiolytic / antidepressant / mild euphoriant)…..I hear ALOT of people trashing it 8mg tabs or higher lol….b.s. …..if you took 8-16mg of pharmaceutical grade Deschloroetizolam you’d be ROCKED !!!!

I had 3,000 to 5,000mg of Deschloroetizolam about 10-15 years ago. Original batch was pretty much 99.9% pure / pharmaceutical grade ….my second batch looked totally different (sparkly crystalline flakes as a posed to the super fine beige/tan beach sand type powder of first 99.9% pure batch

2mg was noticeable while Benzo naive
4mg was a proper dose (sufficient enough to eliminate anxiety in 30-45min / 1h full onset / 8-12h duration
6mg was nearly identical to 1-1.5mg Alprazolam

Almost the perfect scientific study as me as the test subject, benzo naive, 27 M 200lbs 6’ empty stomach, Deschloroetizolam 6mg (properly dosed/weight/several methods to triple check) accurate 2mg increments +. Onset identical to Etizolam, 30-45min, slightly longer lasting 8-12h of noticeable anxiolytic properties. I remember being VERY uplifted & euphoric, walking to corner store on a sunny summer Sunday afternoon floating on a cloud, inner joy, cheerful, robust anxiolytic & antidepressant)

Etizolam 1mg
Deschloroetizoalm 4-6mg
Diclazepam 1mg (2-Chloro-Diazepam) pro-drug to > Delorazepam >> Lorazepam (Ativan)
Diazepam (Valium) 10mg
Alprazolam (Xanax) 0.5mg
Lorazepam (Ativan) 1mg
Clonazepam (Klonopin) 0.5mg

All the Benzo’s in my vault…..Diazepam (Valium) 10mg are GOLD.

Deschloroetizolam 6mg is a VERY effective Anxiolytic with mood-boosting & antidepressant effects
 
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Dextro .45 said:
Yes, Deschloroetizolam is AMAZING …I’ve always loved it. Actually more pleasurable & euphoric than Etizolam. Slightly less potent and longer duration of action

Etizolam 1mg
Deschloroetizolam 4-6mg

Deschloroetizolam is like the Xanax (Anxiolytic & Antidepressant) to Triazolam (Hypnotic/Sedative) “Etizolam“ …..I hear ALOT of people trashing it 8mg tabs or higher lol….b.s. …..if you took 8-16mg of pharmaceutical grade Deschloroetizolam you’d be ROCKED !!!!

I had 3,000 to 5,000mg of Deschloroetizolam about 10-15 years ago. Original batch was pretty much 99.9% pure / pharmaceutical grade ….my second batch looked totally different (sparkly crystalline flakes as a posed to the super fine beige/tan beach sand type powder of first 99.9% pure batch

Etizolam 1mg
Deschloroetizoalm 4-6mg
Diclazepam 1mg (2-Chloro-Diazepam) pro-drug to > Delorazepam >> Lorazepam (Ativan)
Diazepam (Valium) 10mg
Alprazolam (Xanax) 0.5mg
Lorazepam (Ativan) 1mg
Clonazepam (Klonopin) 0.5mg

All the Benzo’s in my vault…..Diazepam (Valium) 10mg are GOLD.

Deschloroetizolam 6mg is a VERY effective Anxiolytic with mood-boosting & antidepressant effects
Click to expand...
Thank you. I like it too.
 
Dextro .45 said:
Yes, I believe so.

it was invented for an antidote for biological weapons/warfare as a 3 part auto-injector pen, containing Atrophine, Avizafone, and another substance

they needed a water soluable, rapid acting form of Diazepam (Valium) and so the pro-drug Avizafone (Pro-Diazepam) was synthesized

Im interested in trying it ….but again, much rather have Valium 10’s. My current benzodiazepines

1) 2-Chloro-Diazepam
Diclazepam > Delorazepam > Lorazepam (Ativan)

2) Diazepam (Valium)

3) Avizafone (Pro-Diazepam)

4) Etizolam & Deschloroetizolam
Click to expand...
Luckyyyy
 
DaiBanto said:
You are right as far as I can tell about avivazone. But as it doesn’t seem to provide a rush and diazepam has such high oral bioavailability, the expense—and it is expensive—doesn’t seem worth it.
Click to expand...
I had brand name Valium once it was great kicks in 5 mins
 
Avivazone was developed as a nerve gas ‘antidote’…there’s your answer. Stick to diazepam unless you’ve been gassed.
 
DaiBanto said:
Avivazone was developed as a nerve gas ‘antidote’…there’s your answer. Stick to diazepam unless you’ve been gassed.
Click to expand...
What a stupid thing to say.

It has been known for years that benzodiazepines rapidly antagonize seizures induced by organofluorophosphates. In the event of nerve gas poisoning, a combination of three drugs is commonly used: an anticholinergic (e.g., atropine), an acetylcholinesterase reactivator, and an anticolvusant (this is where an injectable, water-soluble benzo like Avizafone comes in handy). A self-administrable injectable treatment containing 2 mg of atropine, 350 mg of pralidoxime, and 20 mg of Avizafone has been suggested as a treatment for nerve gas poisoning.
 
You wrote a informative post about how avivazafone was developed as a water soluble pro-drug that the body converts into diazepam (actually you may have omitted that it was a PRO-drug, like vyvanse) as part of the treatment for some forms of nervegas. One wonders why Big Pharma didn’t use one of the powerful water soluble benzos they already have languishing on their shelves. But I’m much too stupid to answer that question.
Um…it’s true that I omitted the other drugs in the cocktail of the antidote
 
Vastness said:
You'd HAVE to inject it? As in, it isn't orally active?

It seems like it should be, given that it's water soluble so should be fairly easily absorbed into the bloodstream through mucus membranes, right, meaning that even if for some reason it can't just be eaten, it should be possible to take it sublingually or even to snort it (unlike diazepam itself, interestingly).

Anyway I haven't tried it but this is pretty interesting, had not heard about it before now and doing a little bit of googling. I'm sure it should be possible to just eat it though, probably it would have a slightly slower onset than diazepam but maybe not appreciably. It seems like this just hasn't been done due to it's usual application for IM autoinjectors in combination with some other stuff as an emergency treatment for poisoning with nerve agents (I forget the exact details but they're also pretty interesting). It is kinda surprising tbh though that it hasn't been discovered and "abused" by now so maybe I'm missing something.
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It is very much more expensive than an equivalent RC benzo, which deters poor users like me. There are other water soluble benzos if that interests you.
 
DaiBanto said:
It is very much more expensive than an equivalent RC benzo, which deters poor users like me. There are other water soluble benzos if that interests you.
Click to expand...
Makes sense regarding the price I guess. As far as water soluble benzos, which ones? I can believe there might be, but certainly the vast majority of the best known ones are not, although that hasn't stopped people trying to snort them.

I'm wondering if you responded to the guy above asking this exact question with "do you own research" which I will if needed but I'm thinking I must have misunderstood because if I didn't then that's kinda rude IMO, just name some of the compounds you were thinking of, in less keystrokes that it took you to be dismissive.


Edit- too curious so did my own research. Fosazepam is water soluble, a diazepam derivative which seems to be fairly weak in terms of desirable effects, linked to declines in sleep quality and duration despite sedation, linked to greater rebound anxieties, just not as good at treating any of the stuff benzos usually are for, which is probably why it's not common.

Midazolam interestingly becomes water soluble around PH levels of <4, which means it would readily dissolve in stomach acid, perhaps that means faster absorption via diffusion through the stomach walls into the blood but I'm not sure what it means beyond that since human blood is alkaline enough that it would become lipophilic again.

In any case - it would appear water solubility in benzos is uncommon - still would be interested to hear of any others.
 
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DaiBanto said:
I like your gall….but how about ‘doing your own research?’
Click to expand...
Besides bromaz I haven’t found many that would be seem to be good. Simply asking your preference. I had etiz once and I guess it was alright just sorta knocked me out though
 
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