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Benzos Are benzos affected by the pH of your stomach when you take them?

Bomb319

Bomb319

Bluelighter
Joined
Nov 26, 2011
Messages
583
Location
Kelowna, B.C.
I know that this is absolutely essential when it comes to methadone; a high-acidity stomach can result in up to ONE THIRD (33% !!) of your dose being excreted unchanged. That is a simply enormous effect - as my dose is 220 mg methadone daily, a very acidic stomach may mean a whole 77 mg or so will literally go down the toilet!!

Anyway, I'm also taking Zopiclone (Imovane in Canada) which you don't have in the US - however, you Do have Lunesta which is the racemic mixture of Zopiclone. Therefore, for all intents and purposes, you can substitute Lunesta in your experiences with this. I took a large dose of 15 mg a full 3 hours ago, and feel next to nothing!! Normally, this drug knocks me out flat in as little as 20 minutes to a half hour...every other time I've taken it. I usually do take it on a completely empty stomach, but today I had eaten 2 slices of buttery toast - not much food at all, so I wasn't worried.

What I suspect is that since I went to great lengths (as always) to raise my stomach pH before my morning daily methadone, the zopiclone may be affected in the opposite way - requiring acid to properly absorb. Does anyone know, or have any experience with this?? I would REALLY appreciate ANY advice, input, experiences etc. at all; this is a very big issue for me, since I have severe and chronic insomnia. I can't stop taking the zopiclone, and I absolutely can't stop the methadone!! BUT what I may be able to do (with your advice) is figure out an acidity schedule to try and make them both work!

None of this is even necessary until I KNOW for a FACT that acidity does affect Zopiclone (or benzos if they have the same issue with them). I'd really appreciate it, guys and girls :) Thanks so much for your time <3<3 :) :) :D :D !
 
Benzodiazepines in tablet form tend to exist in their freebase form, not as a salt, except for midazolam, (can't speak for z-drugs) typically they are not significantly effected by normal digestion you'd have to have some pretty serious chemical imbalances.
 
tricomb said:
Benzodiazepines in tablet form tend to exist in their freebase form, not as a salt, except for midazolam, (can't speak for z-drugs) typically they are not significantly effected by normal digestion you'd have to have some pretty serious chemical imbalances.
Click to expand...

Yeah, but it isn't a benzo. It does have benzo effects because it acts on GABA by increasing its transmission, but it has a different structure. It's one of the so-called Z-drugs.
 
IME in traditional benzos like alprazolam isnt not affected by ph levels well for me anyway hell as a matter of fact it has settled my stomach plenty of times when i have induced "acid reflux" caused by my waves of anxiety
same goes for diazepam, ativan and klonopin
 
Bomb319 said:
Anyway, I'm also taking Zopiclone (Imovane in Canada) which you don't have in the US - however, you Do have Lunesta which is the racemic mixture of Zopiclone.
Click to expand...

It's the other way round - Imovane is racemic (i.e. a 50:50 mix of R-Zopiclone and S-Zopiclone) and Lunesta is enantiopure ("Eszopiclone" simply means "S-Zopiclone", i.e. that it only contains the S-enantiomer).
 
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