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Opioids Anyone done hydromorph contin?

You know, William S. Burroughs mentions Dilaudid (hydromorphone) in his autobiographical novel 'Junky'. Someone else mentions it him and that that they would use the thick end of a wooden toothpick to measure the dose (of powder). They go on to say a lot of people OD on the stuff. now even the thick end of a toothpick is quite small.

It's also the opioid that kills the character 'Nadine' in the film 'Drugstore Cowboy'.

Be very careful.

As others have noted, pills are not designed for any other ROA so there are extra risks associated with doing so.

If you can enjoy them by just swallowing the stuff, I would suggest it's the safer option. Yes, oral bioavailability isn't great, but it sounds like it's enough.
 
You know, William S. Burroughs mentions Dilaudid (hydromorphone) in his autobiographical novel 'Junky'. Someone else mentions it him and that that they would use the thick end of a wooden toothpick to measure the dose (of powder). They go on to say a lot of people OD on the stuff. now even the thick end of a toothpick is quite small.

It's also the opioid that kills the character 'Nadine' in the film 'Drugstore Cowboy'.

Be very careful.

As others have noted, pills are not designed for any other ROA so there are extra risks associated with doing so.

If you can enjoy them by just swallowing the stuff, I would suggest it's the safer option. Yes, oral bioavailability isn't great, but it sounds like it's enough.
I agree . I do chew them . But haven't tried to crush because I've read on here horror stories of getting particles in the lungs. I take hydromorphone for two reasons, pain and not to withdrawal. I don't get high like I would on oxys. I'm talking insufflating. I know the wonderful high iving dilaudid. I would eventually get 3mgs every 2 hrs in hospital. I literally didn't want to leave. I was euphoric, eating hospital food like it was a kings meal. Going out for smokes, flirting with nurses. Life was good . But that's what got me on to opioids. Definitely my fault. I knew what I was doing. That's why I warn any addict to low dose on iv hydromorphone. Or avoid if you can.
 
Soak the beads in water for 24 hours, filter, and inject. Just make sure you don't OD, I would make a solution that had about 16mg/ml. That way you can draw up half a cc at a time, and know it's 8mg. They are only good for constipation taken orally. IV, they are the bees knees. I love em.

Your suggestion got me curious. I have an OP80 -- you know those hard gelatin pills that can't be crushed up. They replaced OC80s after Perdue got so much heat for causing the opioid epidemic. Anyway, I'm wondering if soaking it in water for a day or two would do the trick. I don't intend to inject it -- I figured I'd just drink it (or maybe take it rectally). The point is, I just want to break the time release. But I don't want to do it until i get confirmation that it works, because this one pill was crazy expensive!
 
Your suggestion got me curious. I have an OP80 -- you know those hard gelatin pills that can't be crushed up. They replaced OC80s after Perdue got so much heat for causing the opioid epidemic. Anyway, I'm wondering if soaking it in water for a day or two would do the trick. I don't intend to inject it -- I figured I'd just drink it (or maybe take it rectally). The point is, I just want to break the time release. But I don't want to do it until i get confirmation that it works, because this one pill was crazy expensive!

Someone mentioned this a while ago. The answer was to place it in warm water - to emulate the environment of the intestines, I suppose. But I'm also told that a new sustained release system relies on osmosis and so there actually needs to be electrolytes in the liquid to 'push' the active out.

80mg IS a lot so be very careful. I imagine even taken as is, it's effects would be pretty potent.
 
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Someone mentioned this a while ago. The answer was to place it in warm water - to emulate the environment of the intestines, I suppose. But I'm also told that a new sustained release system relies on osmosis and so there actually needs to be electrolytes in the liquid to 'push' the active out.

80mg IS a lot to be very careful. I imagine even taken as is, it's effects would be prerry potent.
Thanks. There was a time when I could rail a whole OC80 and still not get much of a buzz, but that was a long time ago so I'll be careful. Anyway, the important thing is -- you don't think there's any chance that the water soaking thing could somehow cause it to lose potency, right? I'd sure hate to waste it!
 
Thanks for foregiving me the host of typos. All the letters have rubbed off my keyboard so I have to touch-type.

No, oxycodone is less stable in solution than it is in pill form but it won't lose potency over a few days.

I have mentioned this elsewhere but oxycodone is MORE potent if consumed orally. This is because it undergoes first-pass metabolism by the liver and around 11% of an oral dose is metaboized into oxymorphone (which as you may know, is some x10 more potent than oxycodone). In fact, it may represent 50% of the activity of oral formulations.

Certainly I noted a HUGE subjective difference the few times I tried snorting OCs. Much more stimulating and sort of plasticly, if you understand my meaning. So defeating the SR may be of benefit but I went on a crusade to convince people to simply swallow the stuff. I mean, if you defeat the SR, it hits inside 30 minutes and you can expect a warm rush to continue for a full 30 minutes and keep you there for 4-6 hours. Snorted it was gone in maybe 2, 2.5 hours.

So it's both HR and best option just to swallow them.

I THINK I heard of people using Everclear or Polish Spirit to dissolve the formulations that used polyamides to prevent abuse.

I know that people used those Pedegg things to grate up pills. I don't know if it's applicable in this case but I can't see it failing in a manner that would waste the stuff.

If you haven't used for a while - go slow. You can always take more to titrate to the effects sought. Yes, it may take an extra 30 minutes but better that than dying for a buzz.
 
After a bit of forum searching, I found that soaking them in CocaCola is a common way of breaking the time release. Anybody try this?

Interesting side note -- back in my younger days, I remember hearing that you should drink grapefruit juice to make the OC effect more powerful, but then someone else told me that the acids in the juice can damage the opioid, so i had this whole ritual where i would chug grapefruit juice, wait 20 minutes, take an antacid, wait another 20, then take the pill. Sort of funny because apparently people are soaking them in lemon juice and various other acidic liquids to break the time release! I think i was mislead about needing antacids... 🤷
 
haha. nodding out at the keys.

Yeah, if you are new to opies, don't shoot this. try oral or nasal. Some people find plugging to be good, I think snorting is way better. Try to avoid mixing such large amounts of downers, as you need less of both for equivalent effects.
Nasal definitely works and is a lot more effective than oral. I have not tried IV but I would never inject pills, especially not anything in time release form.
 
After a bit of forum searching, I found that soaking them in CocaCola is a common way of breaking the time release. Anybody try this?

Interesting side note -- back in my younger days, I remember hearing that you should drink grapefruit juice to make the OC effect more powerful, but then someone else told me that the acids in the juice can damage the opioid, so i had this whole ritual where i would chug grapefruit juice, wait 20 minutes, take an antacid, wait another 20, then take the pill. Sort of funny because apparently people are soaking them in lemon juice and various other acidic liquids to break the time release! I think i was mislead about needing antacids... 🤷
You were misled.
 
After a bit of forum searching, I found that soaking them in CocaCola is a common way of breaking the time release. Anybody try this?

I seem to remember the comment. It wasn't very scientific but if I remember correctly, they suggested placing the cola on top of a walm surface. I guess the pH of cola and it being at roughly the same temperature as the digestive system might overcome the ORIGINAL formulation of oxycontin.

But I believe in the US oxycodone has been reformulated two or three times. If memory serves first they made an uncrushable format and people used hammers, vices and such to defeat that one by force. They they swapped to a polyamide formulation that wasn't particularly water-soluble so at least if crushed, the result still couldn't be snorted. You mentioned a gelatin-like formulation which may or may not be that polyamide formulation. I've never seen it.

But at the end of the day the tablets have to be designed to release oxycodone over 12+ hours in the digestive tract. Skorpio pointed to the latest concept was a formulation that used osmosis i.e. the weak solution of electrolytes in the gut would leech into the tablet and that in turn would leech the active compound out. It's a great idea but at the end of the day, the oxycodone can only be absorbed as a solution so while you may have to estimate the condistions within the digestive tract more closely, if you are prepared to wait, all of the active will eventually end up in solution..

I admit I don't keep a close watch on the evolving technologies designed to prevent abuse because I just take as prescribed. If I get enough relief to remain mobile, I'm not looking for more.

But I hope the above explains my understanding of the matter. Take care.
 
Okay I just discovered this bluelight post that started shortly after OPs came out. I read a couple pages and said "Screw this! I'll just chew em up and hope for the best!"

I probably would have been up for it in my younger days, but now, I'm not using acetone on something that goes into my body!
 
II didn't bother to read the whole thing but 'chew em up and hope for the best' is by far a safer option.

I mean, even over 12 hours, to me 80mg still seems like quite a hefty dose.
 
Well I kept changing my mind, but in the end, I decided to try the coca cola and vitamin c method. I let it soak for around 12 hours. Then this morning, just to be safe, I drank half of it, waited a half hour, and then drank the rest. It's been ages since I've done oxy, so i can't say for sure since I have no basis for comparison, but i do think it worked, at least partially. I've mainlined H a few times in the past month (black tar, and pretty shitty quality i would guess), but after drinking that oxy concoction this morning, this is the first time in years I've felt that lovely blissful opioid feeling that I've been missing. ❤️🥰❤️
 
Well, I'm sure I don't need to say that it's much better as an occasional treat than as a way of life.

Did the thing dissolve? I'm curious but it may be the case that the pill simply leeches out the active as electrolytes leech in - which may make people think that their efforts had no result.
 
Well, I'm sure I don't need to say that it's much better as an occasional treat than as a way of life.

Did the thing dissolve? I'm curious but it may be the case that the pill simply leeches out the active as electrolytes leech in - which may make people think that their efforts had no result.

So i cut the pill into four quarters before dropping it in there, and when i checked it this morning, it looked like it was mostly dissolved, but I could see a couple little bits on the bottom that sort of looked like little globs of snot. 😝 So yeah, I'd say it was mostly dissolved.

Here's hoping i can keep my usage down to the occasional treat. 🤞 I'm very glad to find that i can get to where i want without needles! And hopefully the fact that it now requires three hours of driving for me to score the stuff will keep my usage in check.
 
Your suggestion got me curious. I have an OP80 -- you know those hard gelatin pills that can't be crushed up. They replaced OC80s after Perdue got so much heat for causing the opioid epidemic. Anyway, I'm wondering if soaking it in water for a day or two would do the trick. I don't intend to inject it -- I figured I'd just drink it (or maybe take it rectally). The point is, I just want to break the time release. But I don't want to do it until i get confirmation that it works, because this one pill was crazy expensive!
They might be different but over here I’ve had luck with time release oxycodone 80s by placing them in slightly acidic water overnight. Then drink, as per your desired IRdosage. I’m not sure it gets rid of all the time release, but it gets rid of most. It’s a very hard green pill and I would not be surprised if there’s a lot of gelatin in it, based on how it reacts in solution as well.
 
It seems like the UK is almost unique in still using the original Oxycontin formulation.

That is to say 40% of the active drug is designed to be released immediately and then the remaining 60% is designed to be released slowly. In theory this means it still provides pain relief quite quickly but in theory, it keeps the plasma level of the drug the same over 12 hours.

In theory. In fact I posted a paper that showed mean pain relief was 9.6 hours (study of 1152 patients). So I take mine TID. It works and I don't fall over (40mg and I DO).
 
It seems like the UK is almost unique in still using the original Oxycontin formulation.

That is to say 40% of the active drug is designed to be released immediately and then the remaining 60% is designed to be released slowly. In theory this means it still provides pain relief quite quickly but in theory, it keeps the plasma level of the drug the same over 12 hours.

In theory. In fact I posted a paper that showed mean pain relief was 9.6 hours (study of 1152 patients). So I take mine TID. It works and I don't fall over (40mg and I DO).
By original formation do you mean the OC80s? They are very easy to get in Sweden. Mundipharma brand. I used to shoot 80mg at a time, shit was awesome
 
By original formation do you mean the OC80s? They are very easy to get in Sweden. Mundipharma brand. I used to shoot 80mg at a time, shit was awesome

I thought OC was merely shorthand for OxyContin? I don't know because in the UK people are almost always prescribed a generic medication.

It's interesting to read the history of oxycodone. When it was first produced in Europe during the late 1920s it escaped legal control. It was produced as a compound medication in the form of 5mg oxycodone, 325mg aspirin and the perception was that it was merely an alternative to codeine. But it doesn't take a genius to realize that the aspirin could easily be removed and the first oxycodone epidemic occured.

Oxycodone first popped up in the US during the 1950s in that exact same formulation. Then it quickly expanded with oxycodone/paracetamol (acetaminophen) and latterly oxycodone/ibuprofen. So a user could pop two of each. In fact, the hard limit on paracetamol is best measured over 24 hours with the simple rule 'not more than 4 grams in any 24 hour period'. But you get the idea. People quickly realized that while at low doses oxycodone IS subjectively similar to codeine, but it's quiite different at high doses.

Then of course the third wave was entirely due to Perdue and their aggressive sales tactics. Apparently the KEY advantage of OxyContin was that it was supposed to relieve pain for 12 hours. Doctors were told that if a given dose didn't last for 12 hours, the patient simply needed a larger dose. Of course, new studies reveal that OxyContin's mean analgesic duration is just 9.6 hours so patients would end up on a roller coaster with euphoria for a few hours, analgesia extending a few more hours and then a couple of hours in which they would begin to go into withdrawal.

Now I ONLY consume oxycodone for severe chronic pain. I'm not looking for anything else. Recently a 24 hour formulation has arrived on the UK market. Onexila XL s supposed to be a once-a-day format but the BNF provides absolutely no information on the product. It used to be available in only one strength - 80mg. But I've noted that more recently 10, 20, 40 as well as 80mg formulations are now available. I am VERY tempted to ask about this product but I cannot find any data on bioavailability or on the true duration of action. I don't want to discover that it only lasts for 20 hours. I also considered asking about methadone but in the UK, Physeptone tablets are solely used to treat pain (being taken every 8 or 12 hours) whereas methadone linctus is solely used to treat opioid dependence. In the last few years there have been saveral shortages of the tablets BUT UK law means doctors cannot legally prescribe the linctus for pain!
 
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