Antacids/Vomiting on the come-up

[nemesis-a]

i usually get gas/nausea on good pills. just smoke herb and try to wait it out

 

[PULS8R]

if ur a junkie and want more then orally take half and snort half or something. u only spew by taking it orally cuz it settles in ur stomach.

Now that you've signed up, maybe you'll learn something. Who are you calling junkies? People that want more out of a roll, or want to roll harder? Nothing wrong with that at all. Get the fuck out of here with your judgmental bullshit.

Some people just have this reaction to mdma, especially if its a good pill. Because the mdma is absorbed through the stomach it can cause upset. Most people find they vomit and the roll is still strong.

A friend never chucks on average pills, but if he takes a few or a really good pill he'll chuck.

 

[VelocideX]

I heard somewhere that grapefruit juice is a good way to prepare your stomach for pills.I think i heard that it turns the stomach more alkaline so theres less acid to destroy the pills active ingridients.Cheap and readily available too. So i tried it last night and i seemed to get a much stronger hit off my first pill.
Can anyone clarify this?

Grapefruit does make your stomach more basic. It contains a substance which inactivates one of the CYP liver enzymes (3A4, from memory). This is not the major metaboliser of MDMA, though, which is CYP2D6. Thus the effect on the intensity should be minimal.

 

[BilZ0r]

Hang on, grapefruit makes your stomach more BASIC?
*BilZ0r busts out some pH paper and tests his Ruby Red Grapefruit Juice (thanks ocean-spray). pH = 2.5-3... I don't think thats gonna effect your stomach pH that much, as thats about it's pH too.

When it comes to the various CYPs that take out MDMA, although everyone says CYP2D6 is the only enzyme that truley degrades MDMA (as its classically said that CYP3A4 just turns MDMA to MDA. Now while I'm not too sure how these enzymes contribute, but CYP1A2 and CYP3A4 certainly contribute to a degree. So inhibition of CYP3A4 by grapefruit juice might contribute. The question is how much CYP3A4 does grapefruit inhibit.

 

[PULS8R]

I drank a litre of grapefruit juice an hour or two before my roll. I took a pill that was very very good and clean mdma, it didn't hit me that strong until i took another half of a less quality pill, then I was floored. ALl my friends were floored off the same very very god pills and didnt drink any juice, so personally I think grapefruit juice does nothing to make you roll harder.

 

[BilZ0r]

I suspect you are right, but then again, it can really depend on the grapefruit juice.

 

[PGTips]

ii was under a different impression about them however. the acids in ur stomach eat up the mdma

The MDMA we consume is already bonded (in a weak way) with HCl, the acid in our stomach (freebase MDMA is messy) so the acid doesn't "eat up the MDMA".
You can take E on some anti-depressants, SSRIs, you just won't get any effect at all.

if ur a junkie and want more then orally take half and snort half or something. u only spew by taking it orally cuz it settles in ur stomach.

You don't need to be " junkie" to take more than 1 pill, so please refrain from insulting about 90% of the members on your 3rd post or so by making a wild generalisation. I know you posted to be helpful, and thankyou for that, but sweeping generalisations are always wrong

 

[hdang]

Now that you've signed up, maybe you'll learn something. Who are you calling junkies? People that want more out of a roll, or want to roll harder? Nothing wrong with that at all. Get the fuck out of here with your judgmental bullshit.

geez bit sensitive r we. i didnt know ud get upset by me saying junkie, if i knew this was gona happen i would have worded it better. ur from PGA yeh? me too..



i believe antacids and grapefruit juice is more placebo than anything. as long as u think its good it will be good.

sorry for causing trouble.. im only newb and still learning...