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Amphetamine Permanent D receptor Increase?

I

Illuminateur

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Nov 2, 2009
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To quote from: http://content.karger.com/ProdukteDB/produkte.asp?Doi=193395

"Dopamine D1 receptor (DRD1) levels increased in the dorsal striatum whereas dopamine D2 receptor (DRD2) levels significantly decreased in both the prefrontal cortex and the dorsal striatum but significantly increased in the nucleus accumbens. In order to investigate whether these changes occurred at the transcriptional level, DRD1 and DRD2 mRNAs were detected. The results showed that DRD1 mRNA levels were significantly increased in the dorsal striatum whereas DRD2 mRNA levels were significantly increased in all three brain regions. These results indicate that early D-amphetamine exposure altered the dopaminergic system in the developing rat brain. This change may lead to abnormal perinatal stimulation that may yield long-term consequences."

As I understand it, this means that amphetamine permanently increases the expression of various Dopamine receptors although it may cause temporary down-regulation, esp of D2 receptors.

Thoughts?

The study is 2009, and I am aware that it is done on rats not humans.
 
Fuck .
Shouldn't have taken alot of amps when I was 16/17

now I've quit .

But this sucks if true
 
hey guys its not very clear cut what this increase and decrease will cause in terms of effects. for starters i would guess that more d2 receptors in the nucleus accumbens will increase the tendency to be easily addicted to rewarding behaviours like cocaine, gambling, sex and food

more dopamine activity doesn't always lead to pleasure, it may make you paranoid and anxious, which is what i found months and years after quitting amphetamines. just because you have more receptors doesn't necessarily mean you will be releasing enough dopamine to be feeding them all at once, or does it?

someone with more knowledge please add
 
^ yeah that's true I think .

Too much dopamine is what schitzophrenics have .

It's also occurs in people who are more paranoid, anxious and restless.

You want a perfect amount of all your neurotransmitters.
Too much of one usually isn't good
right?
 
ill tell you what, stopping after one year of mass ammounts of ritalin, adderall, and mostly vyvanse left me with absolutely no positive effects today. i always feel like i wacked my heart way out of rhythm everyday, the amazing amount of weight lost never returned, and the most disturbing thing was that i found myself crying about the most random shit, and felt so sorry myself.......
 
^ yeah that's pretty expected with ADD meds.

Only use them when u really really have to
 
jamesmartin said:
^ yeah that's true I think .

Too much dopamine is what schitzophrenics have .

It's also occurs in people who are more paranoid, anxious and restless.

You want a perfect amount of all your neurotransmitters.
Too much of one usually isn't good
right?
Click to expand...

Amphetamines dont cause schizophrenia...

And I can relate to that. Ive been using quite a lot of amphetamines myself and its caused permanent increase in sex drive. Sadly no increase of appreciation to what I used to like.
 
uhh
they DO cause AMPHETAMINE PSYCHOSIS
stay up long enough adn youll understand
 
Sensitization and tolerance both occur and are involved in addiction,in rodents sensitization seems to be the main response to amp in humans this is tolerance, i'l elaborate more later.
 
LSDMDMA&9098798 said:
uhh
they DO cause AMPHETAMINE PSYCHOSIS
stay up long enough adn youll understand
Click to expand...

Its not the same as schizophrenia. Schizo is permanent while amphetamine caused psychosis is temporar. And Ive experienced psychosis once, it was crazy.
 
LuckyStriker said:
Amphetamines dont cause schizophrenia...

And I can relate to that. Ive been using quite a lot of amphetamines myself and its caused permanent increase in sex drive. Sadly no increase of appreciation to what I used to like.
Click to expand...

In my reply that you were replying to I didn't even mention that amphetamines cause schizophrenia . (they might do . Who knows . I just didn't say it even though you accused me of doing so)

I was actually talking about people who have high dopamine levels if you actually read my post properly
geez
 
jamesmartin said:
In my reply that you were replying to I didn't even mention that amphetamines cause schizophrenia . (they might do . Who knows . I just didn't say it even though you accused me of doing so)

I was actually talking about people who have high dopamine levels if you actually read my post properly
geez
Click to expand...

Oh geez, I misread. Geez geez geez. I have such fucking big problems getting the big picture from texts nowdays. I cant connect...
 
jamesmartin said:
Ya looks like someone has damaged their brain from drug use

Cunt
Click to expand...

Looks like someone is in a bad mood from their drug use. Cunt. Geez, all I did was mireading and you proceed to call me words? Did I ever do that? No.

Now sorry for my last off topic post but this dude is an asshole.

v v

Chill down. Its not like youre the only one to share that opinion, especially not here. I didn't mean to offend you...

I get what you mean. Schizophrenics are paranoid as fuck, delusional and hallucinating and it is THOUGHT to be caused by too much dopamine, so the same mechanism could apply for amphetamines because of the increased dopamine level. Would the increase be significant enough to get as far as turning schizo though?

I MAY have become more anxious due to heavy MDPV usage, I give you that. But this could have been caused by a lot of other reasons like PTSD. I will leave the research to people that have knowledge in medicine and chemistry, and just STFU.
 
Last edited:
Triplefacepalm@this entire thread (aside from Medieval)

And yeah so what if I'm in a mood . Life sucks . I have the right to be in one
Click to expand...

Not really, at least not so overtly within conventional social circumstances. At the very least, people aren't likely to respond positively to assholes simply because those assholes' lives are less-than-pleasant. Similarly, most wouldn't take kindly to babyish insults under any circumstances - of course, this fact is completely irrespective of your fundamental, inalienable right to be pissed off.

Thoughts?

The study is 2009, and I am aware that it is done on rats not humans.
Click to expand...

Mmm? Are you aware that this study solely concerns neonatal rats which, as a rule, form an exceedingly poor model of adult human neurobiology?
 
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