Misc Agmatine Megathread

[agoraphobe]

I feel like there is a lot to cover regarding this substance. Is it more like Ketamine or Clonodine? What does it do as a basic supplement? It's also somehow an opioid potentiator OR just able to reduce tolerance?

Ideas?

 

[red22]

An intriguing finding I recently came across: agmatine synergizes with muscimol:

The involvement of GABAergic system in the antidepressant-like effect of agmatine. Neis, V. B., Rosado, A. F., Olescowicz, G., Moretti, M., Rosa, P. B., Platt, N., Rodrigues, A. L. S. 2020. Naunyn-Schmiedeberg's Archives of Pharmacology, 393(10), 1931–1939. 10.1007/s00210-020-01910-5

𝚀𝚞𝚘𝚝𝚎:

Most anti-anxiety supplements are trash.

But mega-dosing agmatine changed everything for me.

1 tablespoon twice per day = mental armor.

No racing thoughts. No overreactions.

Here's how it works:

1. It activates GABA-A receptors (promotes calm without sedation)

2. Then, it inhibits NMDA receptors (reduces glutamate toxicity)

3. Then, it increases BDNF and activates mTOR (supports brain repair)

4. And lastly, it suppresses HPA-axis overactivity (shuts down stress response)

Unlike benzos or alcohol, agmatine didn't sedate me or blunt
my edge.

It just made me feel chill and in control.

If you're hypersensitive to stress and nothing else has worked, this is the one to try.

h‍ttps://x.com/HansAmato/status/2010026415668744523

 

[KurtAurelius]

I take 3 grams of Agmatine a day.

I feel extremely peaceful, calm, and grounded after taking it,

I notice a very positive effect on vascularity and blood flow,

It makes me sleep extremely deeply,

It alleviates plenty of late night cravings, generally lending me to just wanting to go to sleep.

It’s not a miracle for tolerance in my experience, but for both Caffeine and Methylphenidate it really did seem to prolong positive effects and vastly slow down tolerance.

Abstinence + Agmatine was very effective.

Having Agmatine in the evening helped greatly cover antidepressant effects that Creatine covers for me in the day.

I am very neurodivergent so I am sensitive to all things, I find theanine and creatine psychoactive for instance.

So with that in mind…
Agmatine for me.. is mildly dissociating but I am taking a mega dose, it is very noticeable in peripheral easing from say adrenaline and is slightly sedating at the doses I take but I’ve probably spent my whole life in a flight of fight state and I am likely noticing reasonable late night relaxation.

Agmatine is one of the miracle touted supplements that is actually worth it.

Aside from Vitamin D3 due to living in the UK, Creatine and Agmatine are the best things I take,

The only things that then only moderately compare is Theanine, Taurine, and Magnesium Threonate.

 

[emkee_reinvented]

Supplement, its a prescription here.

Shit happens sound s promising. Bit like l-Theanine.
OTC but expensive. Again over here.

 

[red22]

Agmatine is one of the miracle touted supplements that is actually worth it.

Legal highs tend to be overhyped or they tend to not have a universally static effect. My above reply, the second post, includes evidence of agmatine's synergy with muscimol, which is another legal high with a somewhat good reputation. Both of these chems are GABAnergic. Other legal gabas I'm curious about are mulungu and magnolia bark. I wonder if a stack of substances like these would have the same universal appeal of "drugs".

 

[emkee_reinvented]

Legal highs tend to be overhyped or they tend to not have a universally static effect. My above reply, the second post, includes evidence of agmatine's synergy with muscimol, which is another legal high with a somewhat good reputation. Both of these chems are GABAnergic. Other legal gabas I'm curious about are mulungu and magnolia bark. I wonder if a stack of substances like these would have the same universal appeal of "drugs".

Erytrhina Mulungu didn t feel GABA-ergic when taking it. Not like a known one.

A superb sleeping agent ime att it was pretty unheard of. A rarity.
Put me to sleep but not as in sedating like a GABA aimed drug.
Is it a GABA-ergic ? Is it becoming available.

Very clean, no residual sedation and such. No high/ recreational effect s.
Really wonder what it does Pharmacologic-ally.

 

[emkee_reinvented]

Erytrhina Mulungu didn t feel GABA-ergic when taking it. Not like a known one.

A superb sleeping agent ime att it was pretty unheard of. A rarity.
Put me to sleep but not as in sedating like a GABA aimed drug.
Is it a GABA-ergic ? Is it becoming available.

Very clean, no residual sedation and such. No high/ recreational effect s.
Really wonder what it does Pharmacologic-ally.

Seriously this tree when with the right product was extreme effective.
Got a bunk product to smelled and looked the same. but 0% effect.

But the other time had a extract and the whole bark. Both worked the same.
Only the potency differs. Was not insomniac att. But it felt clean.
And put me out. In no time, could have been placebo.

Last time was during insomnia, it was either bunk or inefficient.

Promising stuff it s a great anti-convulsant as well according to PubMed.
Someone on the site uses Magnolia and felt a mild GABA effect.
Nothing to wright home about.

Never took it myself.

 

[agoraphobe]

I noticed the combination of 1g agmatine and creatine last night after a kratom binge. I just took 2g agmatine and I'm somewhat worried with how strong the effects might be.

 

[General alcazar]

Huh. I’ve been experimenting with amanitas lately with rather disappointing effects. However, one night I made tea with 4 grams, acidified and boiled to decarboxylate, and didn’t so much. On a lark, I took a big scoop (1.5 g) of agmantine with my usual 8 g bedtime kratom dose, and it hit really hard. My intention was to potentiate the kratom (3 hours had passed with no effects from the mushrooms), but now I wonder if the muscimol was potentiated instead. It was a weird sensation; a combination of sedation, dissociation, and lucid dreaming. I made a 5.5 g of the same mushrooms a few days later, and still no effects. I haven’t tried them with agmatine though. I guess I’ll report back.

 

[agoraphobe]

My intention was to potentiate the kratom

I read mixed things. ChatGPT swears that agmatine will blunt kratom euphoria. So I'm hesitant to test it. I did feel like when I took it during mild opiod wd's it prevented my lows from dropping too low. Idk

 

[General alcazar]

Chat GPT can’t ingest kratom or agmatine. I’d be wary of an AI interpretation of a subjective drug experience. Sure, AI can dress your cat like Henry the 8th while riding a unicorn, but it cannot get high. It can only summarize what other people have posted online.

 

[Allylbenzene]

I feel like there is a lot to cover regarding this substance. Is it more like Ketamine or Clonodine? What does it do as a basic supplement? It's also somehow an opioid potentiator OR just able to reduce tolerance?

It shares properties with ketamine, creatine, clonidine, 5-HT2A psychedelics and potentiates GABAergics and cannabinoids. It's also effective for resetting tolerances.

 

[red22]

Curious comment:

There is also a slightly psychedelic edge to it making the combo between it (4 grams or so of amanita) and low dose (1.2 grams) of psilocybe cubensis very enjoyable. Don't use too high of a dose of amanita muscaria though or you will have a difficult time, and it does induce seizure like activity at around 12-14 grams in some people from what I have noticed. YMMV with this one, but it is nowhere near as pleasant as a benzodiazpine and not even close to as euphoric as phenibut.

 

[agoraphobe]

Took 1g Agmatine yesterday at 5pm to practice some abstinence from kratom, Ativan and gabapentin. I was able to fall asleep, but it was uncomfortable sleep.

Also. I was surprised to find my coffee and nicotine being blunted at 7am the following day. That's multiple half lifes. Yet still influencing buzz related things.

I also tested THC on agmatine. Didn't notice any difference other than feeling much less high. Which is contrary to what I read about it potentiating THC. Who knows

 

[red22]

I find the effect of high dose agmatine to be very faint, but still worth it. Its impact is probably comparable to smoking a cigarette when you're in withdrawal. Not good enough but better than nothing.

Synergy with muscimol may be another story however

"The synergistic antidepressant-like effect induced by a combined administration of subeffective doses of agmatine and muscimol (GABAA receptor agonist) suggests that the activation of GABAA receptors is implicated in the antidepressant-like effect of agmatine."

The involvement of GABAergic system in the antidepressant-like effect of agmatine. Neis, V. B., Rosado, A. F., Olescowicz, G., Moretti, M., Rosa, P. B., Platt, N., Rodrigues, A. L. S. 2020. Naunyn-Schmiedeberg's Archives of Pharmacology, 393(10), 1931–1939.  10.1007/s00210-020-01910-5 Discussion, second paragraph

 

[SuperPsych]

I only got what I would consider possible psychoactivity when I took 8000mg at once. Felt very minor dissociation that was extremely brief. Almost felt like the first alerts of an oral dose of a dissociative. Lasted maybe 10 minutes or so then I was back to normal. When I say "mild", I mean mild. Could have just as likely have been a placebo effect. It also can lower blood pressure, so maybe it was the sudden lowering of BP that made me feel strange. I also have PTSD and depression and I can have periods of dissociation but it didn't feel like that.

I will say this though, out of all of the stuff that I've tried that's marketed as a nootropic, agmatine was by far my favorite (not counting Phenibut ofc). It helped my depression pretty significantly for a "supplement". Now it didn't cure me of my depression, like if I was in a deep depression and feeling hopeless; the agmatine would lighten the load off my shoulders just a bit. I was still depressed, but I didn't feel like I was being crushed by it anymore. Agmatine made it so that I could maintain a job and cruise through life through my depression.

 

[red22]

I found it to have what I would describe as the bare minimum positive effect—essentially the same thing that you're saying. That effect required higher doses, but anything above a teaspoon would induce a laxative effect. That's probably because of the sulfate component. Arginine metabolizes into agmatine and I read a very positive testimonial✱ about it, so now I'm going to try arginine as an alternative.

✱"My husband and I have been taking L-arginine for couple of years now. Definitely life changing experience! If you want your blood pressure normal, energy, sex drive, happiness, yes it’s responsible for your happy hormone as well! Get your self L-arginine supplements. I taking little bit more than recommended but didn’t have any side effects. Also started taking it two times a day instead of once. Good luck!"

@YulsLifeStyle  2024-05-22  10 Benefits of L-Arginine  @Drberg  2020-10-19  h‍ttps://www.youtube.com/watch?v=WXZcFlxEgKs"

 

[Chemicalfascination]

✱"My husband and I have been taking L-arginine for couple of years now. Definitely life changing experience! If you want your blood pressure normal, energy, sex drive, happiness, yes it’s responsible for your happy hormone as well! Get your self L-arginine supplements. I taking little bit more than recommended but didn’t have any side effects. Also started taking it two times a day instead of once. Good luck!"

@YulsLifeStyle  2024-05-22  10 Benefits of L-Arginine  @Drberg  2020-10-19  h‍ttps://www.youtube.com/watch?v=WXZcFlxEgKs"

I have discovered this thread a bit late, my goal with this stuff is to relieve some of the body-load that certain psychedelics induce in me from vasoconstriction and searched everywhere for Agmatine and couldn't find any.

What about L-Citrulline? Isn't it the better version compared to L-Arginine, since it doesn't get decimated in the intestines by Arginase and in the liver by first-pass metabolism, is better tolerated by the stomach & GI tract and is absorbed more efficiently?
Furthermore it provides a more steady, long-lasting effect, according to yet another YT doctor, DR. Robert Chan (he focusses on ED in his video) Link

Tried 8g of L-Citrulline Malate with some AMT recently and it worked great in combination with 250mg of elemental Mg from Magnesium Bi-Glycinate.
It drops my BP by 8 mmHg easily and I can feel the warmth circulating in my body as the blood vessels dilate from the produced nitric oxide, for 5 hours at least and nearly had no body-load and no laxative effect at all.
Edit: I wanted to add that after a few hours into the experience I felt a bit too warm, like having a light fever, but I didn't measure so it could have been flushing as well.
I had to go that way since Agmatine itself is not available in the EU, since no-one ever put it in any supplements before 1997 and as such it falls under the Novel Food Regulation and is therefore illegal. Don't you all love that bureaucracy?