Conky
Bluelighter
- Joined
- May 25, 2021
- Messages
- 2,944
First & last name pleaseI live in Victoria BC, at a place called the Johnson st community
First & last name pleaseI live in Victoria BC, at a place called the Johnson st community
Oh, for real. I think that was actually my first comment. So you where actually dead on lol.You must be new here.
We are all on drugs and say random things since we are on drugs.
I hope that clears everything up for you.
That is such an awful thing to have happen.Not a WoW player, I'm in too much pain most of the time.
I got shot in the chest one night by a random stranger {likely a gang initiation} after scrubbing out of surgery and stopping for gas on my way home one night, shattering my clavicle & leaving the bullet still painfully lodged only 1mm over my left aorta. It rendered me with CRPS, also colloquially referred to by us in the medical field as 'the suicide disease', the most painful disease known to mankind, which ranks as a 41 or 42 on the McGill pain scale, one step above having a limb amputated with no anaesthesia {"yes", I prefer the British spelling}. Except, unlike an unsedated surgical procedure, the pain for us afflicted with chronic regional pain syndrome {or, RSD, 'reflex sympathetic dystrophy'} •never• goes away, it only gets worse with time. Most patients end their own lives within the first 3 to 5 years after diagnosis, to stop the constant intense pain, but I just keep going after over 25 years of having this, though I'm not sure how.
Having used every type of known drug on this planet, I am very familiar with the pharmacokinetics of pretty much everything out there.
All that said, I just posted my answer to your' multiple inquiries, and hope that helps, my friend.
Personally, I take a mouthful of Orange Crush {for •both• the acetic acid to increase the potency •&• the carbonation which enhances and speeds up the mucosal membrane absorption} and then pour a powdered 30mg oxycodone into my mouth, swish it around for ten minutes and then swallow. The analgesic effects are {quite literally} staggering. It's the only thing that reduces my agonizing pain, and I do that 3 times a day, along with Klonopin, tizanidine {zanaflex}, cyclobenzaprine {flexeril}, clonidine and metapropolol to reduce my BP, which skyrockets to over 160/120 when my pains at it's worst.
I'll go more into how to best use potentiators to supplement your' CYP 450 cytochrome inhibitors here when I have the chance to.
I also run a chronic/intractable pain patient support page to keep me busy helping others, since I can't scrub anymore.
Best regards;
∞€lixir£lask
Not a WoW player, I'm in too much pain most of the time.
I got shot in the chest one night by a random stranger {likely a gang initiation} after scrubbing out of surgery and stopping for gas on my way home one night, shattering my clavicle & leaving the bullet still painfully lodged only 1mm over my left aorta. It rendered me with CRPS, also colloquially referred to by us in the medical field as 'the suicide disease', the most painful disease known to mankind, which ranks as a 41 or 42 on the McGill pain scale, one step above having a limb amputated with no anaesthesia {"yes", I prefer the British spelling}. Except, unlike an unsedated surgical procedure, the pain for us afflicted with chronic regional pain syndrome {or, RSD, 'reflex sympathetic dystrophy'} •never• goes away, it only gets worse with time. Most patients end their own lives within the first 3 to 5 years after diagnosis, to stop the constant intense pain, but I just keep going after over 25 years of having this, though I'm not sure how.
Having used every type of known drug on this planet, I am very familiar with the pharmacokinetics of pretty much everything out there.
All that said, I just posted my answer to your' multiple inquiries, and hope that helps, my friend.
Personally, I take a mouthful of Orange Crush {for •both• the acetic acid to increase the potency •&• the carbonation which enhances and speeds up the mucosal membrane absorption} and then pour a powdered 30mg oxycodone into my mouth, swish it around for ten minutes and then swallow. The analgesic effects are {quite literally} staggering. It's the only thing that reduces my agonizing pain, and I do that 3 times a day, along with Klonopin, tizanidine {zanaflex}, cyclobenzaprine {flexeril}, clonidine and metapropolol to reduce my BP, which skyrockets to over 160/120 when my pains at it's worst.
I'll go more into how to best use potentiators to supplement your' CYP 450 cytochrome inhibitors here when I have the chance to.
I also run a chronic/intractable pain patient support page to keep me busy helping others, since I can't scrub anymore.
Best regards;
∞€lixir£lask
YES. that does clear up SO much! I forgot all about this thread, thank you for that information. Will definitely influence how i use my medication.3.18.22
Great inquisitive reply, cdin, and it's the primary reason that I chose to write my first Bluelight post on this very misunderstood topic. It was time.
After a drug is consumed orally & swallowed, it is FIRST PASS absorbed by the digestive tract, which removes much of many drugs through its' gastric enzymes BEFORE it then enters the hepatic portal {ie. the liver}. Only then is it carried through the portal veinous system and into the liver before it is systemically absorbed by the body. This is the FIRST PASS metabolism effect, which greatly reduces the bioavailability of the drug because of the gastric enzymes FIRST removing much of the drug, in this specific case, oxycodone.
However, significant hepatic extraction still occurs when the other ROA's are instead used, because of SECOND PASS metabolism, which involves the hepatic portal vein and hepatocytes, but BYPASSES first pass gastric metabolism, which is why swallowing oxycodone isn't anywhere as effective as other ROA's. See, the liver still metabolizes oxycodone, but when it hasn't first gone through the gut, there's quite simply a lot more of the medication in ones' system, that hasn't been destroyed by the gastric enzymes. So, in essence, you are not removing the metabolites at all, but you are increasing the amount of the active drug, which then additionally INCREASES the amount of metabolites, such as the oxymorphone that provisions much of the analgesic effects, just as you stated.
Four primary systems affect the first pass metabolism of a drug... the gastrointestinal lumen enzymes, gut wall enzymes, bacterial enzymes, and hepatic enzymes.
Thus, by utilizing alternative ROA's , such as nasal insufflation, IV, IM, aerosol inhalation, suppositories or sublingual, you are only avoiding the destructive first-pass metabolism effect of the gut, and instead only subjecting the oxycodone to SECOND PASS metabolism by the livers' hepatic enzymes, leaving you with a much higher bioavailability.
That's why I wrote all of that, to illustrate the erroneous thinking promoted by most people who don't understand that •second pass metabolism•, well, it beats the hell outta using •first pass metabolism•.
I hope that clears the waters a little more, and I apologize for not including all of that in my first penning.
You rock;
∞€lixir£lask
50x stronger like the amount you need to get high/feel it and/or analgesic effects. But heroin is 1000000000x times more euphoric than fentanyl. This is a common misconception and should be well known so people don't stupidly get into fent, IT DOESNT FEEL GOOD.One post says fentanyl is 50x stronger than heroin the other says it's not enjoyable. That seems strange for it to be that much stronger without being enjoyable...euphoric.
No pharma grade stuff here.
That's subjective tbh. Some ppl like oxy as much as heroin. BUT heroin has a beautiful rush that oxy lacks and oxy is more speedy also. They similar, very euphoric drugs but studies say people like real diamorphine more than oxy. For me, if you're taking oral ozy definitely(better bioavalability and good, fast come up) and if you're injecting ofc heroin is king, no doubt.So oxycodone would be better than heroin??? I don't care which is safe to be honest. I just want the best option high
It's called a pro-drug, heroin only exists outside the human body. As it enters your body, it immediately metabolizes into morphine, 6-MAM and some other metabolites. So yeah, it's morphine that does most of the job indeed.Hmm well you know heroin is just diacetylmorphine, basically it's a morphine that gets you high when you take heroin. Maybe H won't work either? Maybe someone who knows pharmacology better than me can chime in.
Not to worry though, DHC, oxy or bupe will all probably work
Can’t speak for others but my use is only chronic pain related, I don’t like the feeling of being high to the point of nodding even. I DO like my pain control to work longer w less medication, howeverAppreciate it...! I always wanted to contribute more to here, so I'm putting together some more papers to publish here, especially my one face, which is all about potentiation, and I hope you find that one to be informative, as well.
You listed several popular potentiators but if you increase the piperidine {from black pepper} with the good 'ol standbys, as it's effect on metabolism is phenomenal, influencing the metabolism of at least 85% of the pain meds that pain patients take, that with a few other simple techniques that can literally double to triple your body's half lives, just have to be careful how I word it, as I don't want anyone throwing caution to the wind and doing too much of anything I do, to excess, and then dying. I'd never forgive myself.
Talk soon;
€lixir£lask