Opioids 7OH/pseudoindoxyl causing precipitated withdrawal from fentanyl?

[aspiringchemist]

I’m currently dependent on 1-1.5g of street fentanyl daily and haven been for about 10 months; I’ve been dependent on opioids for the past decade.

Every time I try to use 7OH and mitragynine pseudoindoxyl they seem to work initially, causing a building high feeling until about the 45 minute mark at which point I begin to experience withdrawal symptoms that don’t get better until I use more fentanyl, or at least a full agonist. This happens every time I try them; I’ve dosed anywhere from 50mg - 200mg and in varying combinations/quantities of 7OH to pseudo.

I read online, though don’t know if it’s true, that pseudoindoxyl has a binding affinity that rivales fentanyl, giving it the ability to displace fentanyl from the receptor site, and replacing it with a less efficacious or less potent opioid, which in turn results in the user experiencing precipitated withdrawal. Does anyone know if there is any validity to this?

I have read so many reports, both here and on reddit, of people successfully using kratom or these high potency extracts to aid in fentanyl withdrawal and it just baffles me because every time I try, the same thing happens. It feels really good, like a legit opioid high is building for 45 minutes and then without fail at the 45 minute mark I begin to get hot/cold flashes, sweating, shaking, intense anxiety etc. Certainly feels like opioid withdrawal and is relieved by using more fentanyl.

Why do so many fentanyl dependent people have a positive experience with it while I seem to get sick? I was a heavy kratom user from 2014-2024, getting up to 120gpd plus opms so I know it’s not that my body doesn’t interact well with kratom.

Thanks!

 

[headj8]

im literally going thru the exact same thing right now today. I was using the Heat One Fifties Pseudo+ (supposedly its MGM15 and pseudoindoxyl) in Georgia the last few months after being clean from all opiates several years. When this 7oh/ pseudo/ mgm15 federal ban rolled around all the local stores pulled the stuff off the shelves and I couldn't find it anywhere. I stocked up for the ban but that only lasted a few weeks. A week ago today (August 26) I found a local store that had some cheap brand pseudo and bought it and experienced enough relief to get me thru work. I also had ordered a few grams of 7oh from a vendor online even though I don't have any experience with 7oh and the 7oh barely even touched the WDs from the mom/ pseudo. I broke down and reached out to a friend that I knew could find me some fent on the street and used .5 gram over the course of a few days I small amounts to battle the wds and of course it worked well. I did not want to fall back into being on dope again, especially after being sober and in recovery for a long time so I said fuck this im not getting more and I went to the one store that I knew had some pseudo still in stock. Bought two packs and proceeded to take both at the same time bc I was trying to get myself well enough to go to work and drove away from the store. 15 mins later I had to pull over on the side of the road at a gas station bc I started feeling weird, mind you I was already withdrawing some but this was different. About two minutes go by after parking at the gas station and I felt like my body had been turned inside out, it was the most insanely painful and scary feeling I've ever had in my entire life, I thought I was dying. Id been narcaned before in the past and that is the closest thing I can compare to how I felt earlier today. The only conclusion I could come up with was that the pseudo caused me to go into full blown precipitated withdrawal for about 3 hours, I panicked and it scared me so much that I almost said fuck it and went to the hospital but I decided not to. The only thing that started to make it go away was to use more fentanyl which I do not want to do. I couldn't believe it but that's the only thing I can think could cause that to happen. Point being, I've now been back using miniscule amounts of fentanyl the last 6 days and I want no part of that life anymore. I found a vendor online today selling mgm15 tabs and powder and ordered a bunch of it to be shipped over night and im praying that will help relieve whatever the hell is going on. I do have 15 or more Suboxone strips at home and can get more from my provider I just can't get myself to wait long enough to start taking it because work has been so stressful and I cannot be sick whatsoever for my job. Sorry if all of that was rambled im not myself right now but I've been digging online to see if anyone else Is having PWD like effects from taking pseudo or 7oh trying to come off of fent. Hope you have found a solution also.