Stimulants 4-Fluoromethylphenidate (4F-MPH) Megathread

[codename99]

Isopropylpropylphenidate will definitely have less risk of compulsive dosing and hence stimulant psychosis....
But i still largely prefer 4f-mph... 4f-eph is the best phemidate though imo.... more euphoric than eph but extremely dangerously addictive.

First i must say stay away from ethylphenidate. it's a killer Seven fatality's from Ethylphenidate.
In my experience all phenidates are candidates for compulsive redosing.
I recently went through 10 grams in 3 weeks of (±)-threo-4F-MPH hydrochloride and.
I can say it upped my metabolism last 30 pounds and and gave me significantly better focus than MPH. Hence a significant rise in my GPA
Which I am prescribed 80mg a day. hence a significant rise in my GPA
I do have access to a university chemistry lab and test equipment i.e. LC-MS and HR-MS mass spectrometer's so that how i verified what i had,

Though thankfully I have yet to get a batch with even though it would be a case of sloppy synthesis (±)-threo and (±)-erythro-4F-MPH,
it would be interesting to see what effects that would have since
(±)-threo/(±)-erythro mixture, is active at dopamine transporters (DAT), norepinephrine
transporters (NET) and serotonin transporters (SERT), respectively where as (±)-threo-4F-MPH hydrochloride has no SERT effects as far as I know.
\
(±)-threo-4F-MPH did not show any appreciable binding affinity at SERT (IC50 > 10 μM, [3 H]citalopram). Furthermore, (±)-threo-4F-MPH was shown to be about three times more potent than MPH in a drug discrimination assay.[50] Overall, it appears that the acetate group and the piperidine ring must be oriented in the opposite direction..

see 4-fluoromethylphenidate (4F-MPH) and differentiation between the (±)-threo and (±)-erythro diastereomers

 

[ItzCritz]

Sorry, I can’t answer any of your questions, but I just wanted to comment on the dose limit on dexamp. 30mg per day is the highest? Well, without jumping through hoops? I’m prescribed 40 mg/day and my husband is on 90mg/day. He doesn’t take anywhere near that, probably only 1/4 of it a day. I’ve seen people on reddit claiming 60 mg/day is the max in the US, but my SO has never had a single issue with his script.

Old thread but U.S and Australia, we are loosey goosey on our scripts.

 

[Older]

Sorry, I can’t answer any of your questions, but I just wanted to comment on the dose limit on dexamp. 30mg per day is the highest? Well, without jumping through hoops? I’m prescribed 40 mg/day and my husband is on 90mg/day. He doesn’t take anywhere near that, probably only 1/4 of it a day. I’ve seen people on reddit claiming 60 mg/day is the max in the US, but my SO has never had a single issue with his script.

Wow, I was prescribed 10mg/day through my 20s, then 20mg/day through my 30s.
Now that I am a 40-something, I obviously need 30mg/day, but I am certain this would require a referral to a shrink instead of seeing my primary care phys every 3 months, sooo I am hesitant to waste my time driving around each month for just a few extra percent, when it isn't even my ideal med.
My adult ADHD+Autism spectrum was best managed with 2.5-7.5mg desoxyn per day, until my ex-wife started stealing it when I was at work or asleep. This was about 2007, but I told her then "your action has doomed our marriage". True there were no immediate consequences, other than choosing to discibtine that med. But within 5 years, during which I did everything possible to salvage my marriage, my name had been dragged through the mud, and I was added to numerous "do not employ" blacklists due to a combination of loose lips, America's Puritanical heritage, and her family's never ending feud over some bullshit!
So now, I am lonely and have been divorced for 8 years, living with my dad, now that my mom is ash.
I miss living near multiple people who could deliver various grams of many things, but on the plus side: now that I am no longer living in Los Angeles County, I no longer need fear being murdered by the gangsters of the Los Angeles PD or LAC Sherrif's Department! If anyone wants to go dancing somewhere that has cute ravergirls, please invite me!
On the plus side, having minimal expenses has enabled me to write megabytes of text on philosophy, mathematics, computer science, socialism, and software code!

 

[Ottadix]

Hello !

I'm looking for something that would help me with academic work and focus. I'm taking care of a relative with a disability and I really really don't want to have hallucinations . I always feel fatigued, I have insomnia, and I'm unable to concentrate and to memorize things (sorry English is my second language and maybe it's not very clear). I also have ADHD and epilepsy (currently taking lamotrigine and a benzodiazepan). My doctor won't prescribe me Ritalin, and I found that 4-Fluoromethylphenidate could have a similar effect. But I'm worried about possible dangerous interactions with the drigs I'm taking every day for my epilepsy.

I'm thinking of taking 5mg diluted in water in the morning. My son have a prescription for Ritalin (ADHD runs in the family I suppose) and he began at this dosage and increased to a 20mg pill per day.

If you have any advice.

Thanks !

 

[Vagabond696]

4F-MPH is amazing. I take 10-25mg either pray or nasally depending how early I'm up. Usually raw powder. I WORK in mental health/disability so I feel you.

Start at 5mg then work your way up to a comfortable level.

Also modafinil is a safer alternative.

 

[Dextro .45]

4F-MPH (5-7h) is longer lasting than Ritalin (3-4h)

4F-MPH is 3.33 X more potent than Ritalin at inhibiting Dopamine transporter

5mg diluted in water/juice would be a safe start. Even drink half the cup after stirring and wait 30min to see if any adverse effects happens (if you never took this batch before) for safety reasons

I have both, but always take 20-35mg Ritalin

 

[izo]

Hello,

My source of methylphenidate had to put up Prices due to inflation. Now I wonder if 4-mpd had simililar effects and will it substitute good for the original Ritalin? I’ve had ethylphenidate which I found a fair bit weaker and not so euphoric and 3,4-dctmp which was a bit icky all in all due to the Chlor atoms binding so hard to the receptor. Anybody can help out? Is 4f-mpd like the real deal.

 

[negrogesic]

It will partially substitute but 4F-MPH isn't nearly as recreational as plain methylphenidate.

Well in actuality it will full substitute for methylphenidate in terms of its effect as an ADHD medication, and in some regards, 4F-MPH is probably a better ADHD medication because of its longer duration and relative lack of euphoria. But in terms of enjoyableness it isn't a substitute. 4F-MPH has greater specificity for that dopamine transporter than MPH, which isn't a good thing in this case (at least in terms of recreational potential).

It's funny, the psychonaut page for 4F-MPH describes 4F-MPH describes it as, "significantly more euphoric and recreational" than methylphenidate, but whoever wrote that clearly has little experience with methylphenidate. It seems to be a reflection of the common misconception that drugs that are more specifically dopaminergic than related drugs are somehow more abusable, but this isn't the case. A well balanced NDRI is almost always more reinforcing than a more acutely dopaminergic one, and pure DRI's are even less fun.

 

[H3N]

Agree. Plain methylphenidate is euphoric and abusable, 4F-MPH is straight functional

 

[ongos]

I'm curious how Ritalin feels like vs. Amphetamines? I've tried Vyvanse, dextroamphetamine/dexedrine, and Adderall. All prescription btw. At first, I was having anxiety prior to taking any of it but after the feel good effects started to kick in I was fine. I'm curious what can I expect from 10 MG Ritalin? Is it a lot closer to the effect of Adderall than Vyvanse or dextroamphetamine?

 

[emkee_reinvented]

I'm curious how Ritalin feels like vs. Amphetamines? I've tried Vyvanse, dextroamphetamine/dexedrine, and Adderall. All prescription btw. At first, I was having anxiety prior to taking any of it but after the feel good effects started to kick in I was fine. I'm curious what can I expect from 10 MG Ritalin? Is it a lot closer to the effect of Adderall than Vyvanse or dextroamphetamine?

dl-MethylPhenidate has ime a quick jittery peak accompanied by sweating, trembling and raised heartbeat. I always compare its effects to a Cocaine like high especially when snorted ( which you should not do as the binders could wind up in your lungs ) Then at 3 to 4 hours it drops fast, leaving a rebound of ADHD effects. Uncontrollable, overactive and irritating to others. Not a good medication.

d-Amphetamine is the opposite. Slow come up and decline. Little side effects, no appetite suppression and less abuse able. The focus is less pronounced but also feels a lot less forced. More natural you could say.

 

[izo]

and less abuse able

id disagree here.

 

[emkee_reinvented]

id disagree here.

Agreed on disagreeing. In the hypothetical situation that I would take a stimulant for recreation dextro/ or even d/ l-Amphetamine would be my preference.

Lets word it right MPH is more fiending then Amphetamines and a in your face type of high ime. Its not subtle and smooth, the crash often led to continues re dosing. While its not even worth it, and even needs a downer to balance it out a bit.

 

[ongos]

I find all amphetamines abusable lol. I was simply curious about Ritalin. I was assuming it's closer to being like Adderall but also might be similar to Modafinil, stimulating but non euphoric?

 

[ongos]

At what dose? I was only prescribed 10 MG methylphenidate, the quick release form. I feel anxious already just thinking about it lol. I haven't taken it yet. Are you saying it's more addictive than amphetamines? I used to take dextroamphetamine 5 MG tablets every 4 hours at least 4-5x a day was magical to me. It was prescribed. I tried Adderall 5 MG as well every 4 hours but it gave me physical symptoms that I didn't like.

In case I don't like the effects of Ritalin could I use an anti psychotic medication to block its effects or something like Atarax as a downer? Or how about Guanfacine as a downer? My understanding is that Guanfacine is often prescribed in European countries along with Focalin (dexmethylphenidate) for ADHD. I'm not sure if Focalin is prescribed in the U.S.

Is 10 MG Ritalin going to cause me to feel like shit or no?

Agreed on disagreeing. In the hypothetical situation that I would take a stimulant for recreation dextro/ or even d/ l-Amphetamine would be my preference.

Lets word it right MPH is more fiending then Amphetamines and a in your face type of high ime. Its not subtle and smooth, the crash often led to continues re dosing. While its not even worth it, and even needs a downer to balance it out a bit.

 

[negrogesic]

Agreed on disagreeing. In the hypothetical situation that I would take a stimulant for recreation dextro/ or even d/ l-Amphetamine would be my preference.

Lets word it right MPH is more fiending then Amphetamines and a in your face type of high ime. Its not subtle and smooth, the crash often led to continues re dosing. While its not even worth it, and even needs a downer to balance it out a bit.

If its a matter of intranasal methylphenidate versus oral amphetamine, then i'd say the methylphenidate has higher immediate abuse potential. Definitely far more fiending than oral amphetamine.

I personally find intranasal MPH, especially d-MPH, more abusable than amphetamine via any route (although I've never tried IV amphetamine).

 

[emkee_reinvented]

If its a matter of intranasal methylphenidate versus oral amphetamine, then i'd say the methylphenidate has higher immediate abuse potential. Definitely far more fiending than oral amphetamine.

I personally find intranasal MPH, especially d-MPH, more abusable than amphetamine via any route (although I've never tried IV amphetamine).

That's exactly how it went when they prescribed Ritalin to me. Then after lots of bullshit a other psychiater prescribed dex. Once did a extraction on my dextro-Amphetamine tablets but the resulting powder was disappointing. Maybe for the best.

Nasal nor plugged proved to be worth the effort. So I always stuck to oral. But as far as functional goes Amphetamine is way above MPH. I do wonder about how dextro-Methylphenidate time release compares to dex-Amphetamine IR.

 

[izo]

over here its also not that easy to get amphetamine prescribed, its even not available as tablets in pharmacies. they normally put the pure amphetamine sulfate into raspberry sirup to prevent abuse. normally youre lucky if you even get prescribed ritalin as an adult.

 

[negrogesic]

That's exactly how it went when they prescribed Ritalin to me. Then after lots of bullshit a other psychiater prescribed dex. Once did a extraction on my dextro-Amphetamine tablets but the resulting powder was disappointing. Maybe for the best.

Nasal nor plugged proved to be worth the effort. So I always stuck to oral. But as far as functional goes Amphetamine is way above MPH. I do wonder about how dextro-Methylphenidate time release compares to dex-Amphetamine IR.

Yeah, interestingly enough, the most recreational way to take amphetamine is orally. But overall the difference between oral amphetamine and other routes isn't tremendous.

Methylphenidate intranasal versus methylphenidate oral is a world of difference. I was prescribed dextromethylphenidate for years and almost never took it orally (exclusively intranasal). It actually became a nasty habit since I was scripted 40mg of IR (10mg x 4) dextromethylphenidate, along with one 30mg racemic daytrana transdermal patch. The thing is, those patches actually contain 80mg of freebase methyphenidate, and I never put them on my skin but instead stuck them to my gums and quided them like a coca leaf. Thus my total daily exposure to equivalent to racemic methylphenidate was 160mg, and all of it was going through a mucosa of some sort (nose or gums).

I started to experience some stimulant psychosis eventually.

In any event, 4F-MPH isn't remotely as enjoyable or reinforcing as methylphenidate. 4-methyl-methylphenidate is closer to methylphenidate but still very far off. All these 4-phenyl substitutions increase it's affinity for the dopamine transporter, which isn't good thing in this case.

Ethylphenidate was most similar, but I still prefer MPH.

 

[emkee_reinvented]

over here its also not that easy to get amphetamine prescribed, its even not available as tablets in pharmacies. they normally put the pure amphetamine sulfate into raspberry sirup to prevent abuse. normally youre lucky if you even get prescribed ritalin as an adult.

The oldest formulation were caps filled with 5 mg. Someone in the ADD group had a normal home dr. who prescribed them to her. Later on they became tablets pharmacy preparation. Till a commercial party showed up trying to cash in on it and lots of people had to discontinue there use of it.

Only one insurance company paid for the generic house made tabs. Even the minister of health was involved when that commercial party showed up as legally the generics had to be stopped being made.

That and the fact that insurance company's have a big hand in everything and prohibited the compensation of Methylamine by pharmacy's. This left only one pharmacy, the one with the guy making his own Methylamine. I found it very fascinating and stopped my ADHD meds. As it was clear that the whole health care was a mess and not something i wanna be depended on.