roi
Bluelighter
- Joined
- Sep 2, 2013
- Messages
- 1,545
OP:
"
methyl 2-4-fluorophenyl-2-(piperidin-2-yl)acetate
Popped up in the UK after the recent 4-Methylmethylphenidate ban.
Anyone got to try it already?"
______________________________________
Oral Dosage
Threshold
< 5 mg
Light
5 - 10 mg
Common
10 - 15 mg
Strong
15 - 20 mg
Heavy
20 mg +
Duration
Total
4 - 8 hours
Onset
30 - 60 minutes
Peak
2 - 4 hours
Offset
1 - 2 hours
After effects
5 - 10 hours
Nasal dosage = slightly lower than oral, with a total duration of 3-6 hours.
4F-MPH is thought to act primarily as a dopamine and norepinephrine reuptake inhibitor, meaning it effectively boosts the levels of dopamine and norepinephrine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear these catecholamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the reward pathways in the brain, resulting in stimulating and euphoric effects.
According to a pharmacological evaluation, the (±)-threo isomer of 4F-MPH is 2.15 times more effective at dopamine reuptake inhibition, and 2.7 times more at norepinephrine reuptake inhibition, than its parent compound methylphenidate. The (±)-erythro isomer, however, is 65 times less effective at dopamine reuptake inhibition and 45.6 times less effective at norepinephrine reuptake inhibition than methylphenidate. Neither racemate of 4F-MPH has a significant impact on serotonin reuptake.[7]
___________________________
Information pulled from psychonautwiki.org
- @deficiT; 8/22
"

methyl 2-4-fluorophenyl-2-(piperidin-2-yl)acetate
Popped up in the UK after the recent 4-Methylmethylphenidate ban.
Anyone got to try it already?"
______________________________________
Class Membership | |
---|---|
Common names | 4F-MPH |
Substitutive name | 4-Fluoromethylphenidate |
Systematic name | Methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate |
Psychoactive class | Stimulant |
Chemical class | Phenidate |
Oral Dosage
Threshold
< 5 mg
Light
5 - 10 mg
Common
10 - 15 mg
Strong
15 - 20 mg
Heavy
20 mg +
Duration
Total
4 - 8 hours
Onset
30 - 60 minutes
Peak
2 - 4 hours
Offset
1 - 2 hours
After effects
5 - 10 hours
Nasal dosage = slightly lower than oral, with a total duration of 3-6 hours.
4F-MPH is thought to act primarily as a dopamine and norepinephrine reuptake inhibitor, meaning it effectively boosts the levels of dopamine and norepinephrine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear these catecholamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the reward pathways in the brain, resulting in stimulating and euphoric effects.
According to a pharmacological evaluation, the (±)-threo isomer of 4F-MPH is 2.15 times more effective at dopamine reuptake inhibition, and 2.7 times more at norepinephrine reuptake inhibition, than its parent compound methylphenidate. The (±)-erythro isomer, however, is 65 times less effective at dopamine reuptake inhibition and 45.6 times less effective at norepinephrine reuptake inhibition than methylphenidate. Neither racemate of 4F-MPH has a significant impact on serotonin reuptake.[7]
___________________________
Information pulled from psychonautwiki.org
- @deficiT; 8/22
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