I've taken 4-AcO-DMT 2 days in a row a few times and 2 days apart twice. I've found that the trip intensity is dramatically reduced if taken 2wice in a row. The visuals were the first to go and what remained was a murky dysphoria. Taken 2 days apart was still a 'meh' for me, although not as unplesaant as attempting to trip 2 days in a row. Mind you, these were all on similar doses and I wanted to find out what would happen. I've never tried with doubling the dose.
It seems that for myself, tolerance is completely reset after 7 days.
Tom
OP; tolerance might even be a bit more severe because of the acetoxy group....just a guess