Well I took 250mg and then snorted about 100mg 15 minutes later as I felt first effects from the oral dose.
Not much else happened. Felt a quasi mdma like high almost develop but never quite got there but instead just mostly felt sober and disappointed. No stimulation whatsoever. Fell asleep like an hour after and woke up 6 hours later completely drenched in sweat.
Not sure yet if it's bunk or if it's my tolerance (or perhaps some from column a and some from column b). I am taking 4f-mph daily in higher than I'm willing to admit doses and have been doing so for awhile, so stimulant tolerance is pretty high. Maybe it's just going to take a lot more material to get me there unless I take a tolerance break first (which is the more sensible approach of course).
I also take Tianeptine daily which does have some action on SERT (see below for description from Wikipedia) but Tianeptines interaction with serotonin is a bit complex and not so straightforward. I have been on it for quite some time now and it has not interfered with similar drug usage in the past. I also looked around beforehand and found reports of Tianeptine users saying 3-mmc worked fine for them. So I don't believe my Tianeptine usage is to blame.
Or perhaps it is a little of column a, b and c. Guess I'll need to take a nice long break before trying again 3-mmc again.
From Tianeptine page on Wikipedia:
Tianeptine is no longer labelled a Selective Serotonin Reuptake Enhancer (SSRE) antidepressant.[39][40][41][42][10][14] Tianeptine has been found to bind to the same allosteric site on the serotonin transporter (SERT) as conventional TCAs.[43] However, whereas conventional TCAs inhibit serotonin reuptake by the SERT, tianeptine appears to enhance it.[43] This seems to be because of the unique C3 amino heptanoic acid side chain of tianeptine, which, in contrast to other TCAs, is thought to lock the SERT in a conformation that increases affinity for and reuptake (Vmax) of serotonin.[43] As such, tianeptine acts as a positive allosteric modulator of the SERT, or as a "serotonin reuptake enhancer".[43]
Although tianeptine was originally found to have no effect in vitro on monoamine reuptake, release, or receptor binding, upon acute and repeated administration, tianeptine decreased the extracellular levels of serotonin in rat brain without a decrease in serotonin release, leading to a theory of tianeptine enhancing serotonin reuptake.[44] The (−)-enantiomer is more active in this sense than the (+)-enantiomer.[45] However, more recent studies found that long-term administration of tianeptine does not elicit any marked alterations (neither increases nor decreases) in extracellular levels of serotonin in rats.[39] However, coadministration of tianeptine and the selective serotonin reuptake inhibitor fluoxetine inhibited the effect of tianeptine on long-term potentiation in hippocampal CA1 area. This is considered an argument for the opposite effects of tianeptine and fluoxetine on serotonin uptake,[10] although it has been shown that fluoxetine can be partially substituted for tianeptine in animal studies.[46] In any case, the collective research suggests that direct modulation of the serotonin system is unlikely to be the mechanism of action underlying the antidepressant effects of tianeptine.[43]
