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Phenethylamines [2C-E Subthread] 2C-E Dosage and Methods of Administration

I find that rectal dosing produces a similar duration of primary effects as oral, it just cuts off a lot of come-up and come-down time (and makes it all much smoother). The peak and plateau last not too much shorter for me, but the whole experience is over quite a bit soonerr because it avoids the lingering aftereffects.

Nasal administration seems to cut each stage down in time, including the peak and plateau. It also increases the bodyload rather than decreases it. For me, rectal is a no-brainer over nasal administration. Rectal seems closer to IM than nasal.
 
I find the nasal come up is much more rapid and intense but the peak and the trip is really not much shorter than oral.

I'm having a hard time with this. I'm not physiologist or pharmacologist.

I can understand differences between oral, IM and mucosal.

But as far as snorting versus plugging

nasal mucosal transmission into the bloodstream > BBB > Brain
anal mucosal transmission into the bloodstream > BBB > Brain

I could understand slight variations in efficiency of transmission through different mucosal tissue morphologies, which would affect maybe dose.

But the mechanism is still bloodstream > BBB > brain.

Why would qualitative effects differ dramatically between anal and nasal?
 
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I have no idea nor do I pretend to. But to me the two methods are quite different. Rectal admin for me is the smoothest come-up, including oral, for most substances, and it preserves at least most of the clarity of the state. Nasal admin tends to be much rougher of a come-up than oral, and the state tends to be more confusing and less mentally clear. I'd love to understand why.

I believe it was F&B who once claimed that he found rectal admin to be closest to IM for him. I have not ever tried IM personally so I couldn't say.
 
pedaltopedal said:
The rate of absorption may be different?
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This i can understand as the difference between oral versus all other dosages.

But I cannot understand that there could be that dramatic a difference between a rapid (relative to oral) transmission into the bloodstream via anal mucousa and rapid (relative to oral) transmission into the bloodstream via nasal mucousa.
 
Ah! I misunderstood the dilemna.

Nasal seems to cause shorter overall effects then oral or rectal, while oral and rectal have mostly similiar durations except for the initial comeup. Naturally, you would assume rectal and nasal to be almost identical, since its getting into the system in relatively the same fashion. Plus, the trip itself is different when comparing rectal to nasal.

Something must be missing from the equation.
 
retired_chemist said:
I find the nasal come up is much more rapid and intense but the peak and the trip is really not much shorter than oral.
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I would have to disagree. Nasal 2C-E lasts a little more than three hours, or perhaps on the short side of four. Orally, it lasts about eight hours, but can last up to ten.
 
Looks like no consensus other than maybe everyone agrees the come up is rapid.

Since individual reactions seem to vary so much, the only thing you can do is your own experiments to see how you react as an individual. Start at low doses of course.

As a side note, don't assume that you can extrapolate experiences with one 2C compound to another. I personally find almost no difference between nasal versus oral administration of 2C-I, unless I have recently eaten a large meal, something I generally never do before doing psychedelics, so I always just parachute it.
 
Mr Blonde said:
^ You find oral 2C-I to be just as fast coming on as insufflated? That's crazy!
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No I find insufflated 2C-I to be just as slow coming on insufflated as oral, which is pretty slow.
 
butane said:
I would have to disagree. Nasal 2C-E lasts a little more than three hours, or perhaps on the short side of four. Orally, it lasts about eight hours, but can last up to ten.
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Smoking (vaporizing) it lasts about 4 hours depending on dosage.
One moment your sober, next moment your peaking. Never had a any body load problems.

Never tried it any other way.
 
Xorkoth said:
^^ Wow, strange... I came up almost instantly with snorted, whereas oral takes an hour to start and 2 to fully come up.
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Initial effects are about 45 minutes, probably almost 2 hours for full come up either way. Yet 2 C-E initial blast off followed by a full 8 hour trip.

I've done a really wide range of types of psychedelics over a really wide range of dosages for almost 3 decades now.

Of all of them the phenylalkylamines definitely seem to demonstrate by far the most variation of individual response to both different compounds as well as different administration.

Just goes to show. When experimenting with a new compound, or even a familiar compound by an untried route of administrations, make no assumptions about what your own response will be even based on your own individual experience, much less anecdotal experience of others.

When ever you try something at all "new" whether it is a totally new compound or just a new route of administration of familiar compound, always start on the side of caution and determine your own response.
 
Xorkoth said:
^^ Smoking 2C-E may be extremely dangerous and release harmful chemicals. Smoke it at your own risk.
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I've personally seen someone cough and then puke a fairly good amount of blood after smoking 2C-E. Gave me a good reason to never smoke any research chemicals, sent me into a weird trip for about 3 hours because it made me wonder what that powder was doing inside my body. It doesn't bother me now but seeing someone throw up blood while tripping on the same chemical can make everything a lil uneasy.
 
Xorkoth said:
^^ Smoking 2C-E may be extremely dangerous and release harmful chemicals. Smoke it at your own risk.
Click to expand...

I didn't know this. Why does this happen? I am vaporizing it. Not actually burning it. None of it is turning black or really discoloring too much.

I have pretty extensive experience vaporizing substances from using meth for 8 years or so. What harmful chemicals are being produced/released?
 
Is there any way to make 2C-E more "snortable" ?
It f*cking hurts, i also noticed that just putting some on the tip of my finger produces very "acid-like"(as in an actual acid, not LSD) symptoms, seems to burn a little.

The way I do it right now :
1- Put the tip of a Q-Tip in water.
2- Using that Q-Tip, make the nasal cavity a little wet.
3- Snort the 2C-E slowly (bump every 5 minutes ... or 30 seconds)
4- Shout and kick!
5- Watch my eyes become reddened from the pain.
6- Sit back and wait.
7- Enjoy.

Seems about right ?
 
When I was a little kid, I touched the stove after my mom had finished cooking. I instantly learned that I should never do that again.

The same principle applies to snorting 2c-x's for me. I tried it once and decided, based on the sheer intensity of pain that I experienced, that I probably should not ever do that again. :\ It feels like there's some real damage being done up there.
 
pedaltopedal said:
When I was a little kid, I touched the stove after my mom had finished cooking. I instantly learned that I should never do that again.

The same principle applies to snorting 2c-x's for me. I tried it once and decided, based on the sheer intensity of pain that I experienced, that I probably should not ever do that again. :\ It feels like there's some real damage being done up there.
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oral is too unconfortable, and i prefer some pain to plugging (which I tried, twice).
Plugging is without a doubt the most effective way of administration for 2C-E I've tried. Never tried IM or IV.

Plugging feels... uncomfortable to say the least.
 
Huh... I've plugged 2c-e on a number of occasions, and I've never noticed any discomfort at all. Everyone's different I suppose.

Edit: I find plugging to be any extremely effective route as well, though, I still feel oral is the best way to go. Oral dosing provides the fullest and deepest trip in my experience.
 
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