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Stimulants 2-FMA to Replace Vyvanse & Toxicity Worries

Q

Quiglesigles

Bluelighter
Joined
May 30, 2012
Messages
78
I recently purchased 1 gram of 2-fluoromethamphetamine and intend to use it to improve motivation at work and school. I have been using doses of 25mg/day and never redose. So far this seems far better than d-amphetamine for me because it doesn't have much euphoria but I am worried about its toxicity (considering that it is a methamphetamine analog).

Can anyone provide any information or speculation on the toxicity of this drug?
 
I was using 70mg per day. I found that it lasted way to long and had negative sexual effects that made it difficult to be productive. It also caused too much euphoria for me which made it fairly addictive.

So nobody has any info on this chemical? If it is anywhere near as toxic as meth I am worried.
 
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Yeah I have, thanks anyway though. I have searched the web for hours and found pretty much nothing.
 
Pretty much all speculation, but I suspect it is fairly non-toxic actually. Methamphetamine neurotoxicity arises largely from oxidation of dopamine and 2-FMA is clearly a much weaker dopamine releasing agent than MA given its difference in behavioral effects.

Regardless, stacking with anti-oxidants (or taking them even when not on amps) is always a good idea!

The other issue may be toxicity of metabolites, and how exactly 2-FMA metabolizes is still somewhat of a mystery. I'm trying to see if I can get a friend with access to GC/MS equipment to analyze some of my piss next time I take it, and figure out what (if anything) it is actually metabolized to. =D
 
I suspect it is fairly non-toxic actually [...] 2-FMA is clearly a much weaker dopamine releasing agent than MA given its difference in behavioral effects.
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A substituted amphetamine, "fairly non toxic"? Don't let the "potency" fool you into thinking it's any safer - commercial 2-FMA is a racemic mix, 50% dextro and 50% laevo (which is motsly inactive), and "street" methamphetamine/desoxyn is 100% dextro. Aside from this (in layman's talk, dl-2-FMA is about 50% as potent as d-meth), they are very similar drugs.

racemic 2-fluoromethamphetamine has about equal potencies for releasing monoamines as racemic methamphetamine. So expect similar issues with tolerance, dependence, toxicity etc.

Vyvanase is the safer drug.
 
I'm not going to do it, as I do not use anymore, nor to I support such use; but does that mean if 2-FMA dosage was increased to double that of meth, that the effects would be a lot more alike?
 
sekio said:
racemic 2-fluoromethamphetamine has about equal potencies for releasing monoamines as racemic methamphetamine. So expect similar issues with tolerance, dependence, toxicity etc.
Click to expand...

Subjectively at least, 2-FMA feels like an extremely weak dopamine releaser in comparison to MA, even taking into account the fact it is racemic. I'd rank 50mg of racemic 2-FMA to be approximately as euphoric as 5mg of d-meth (~90% purity), or roughly 5 times less euphoric for the more active dextro isomer.

Although if you've got any actual studies saying otherwise, I'd be perfectly well inclined to believe them and chalk it up to some other mechanism that is causing it to be so much less euphoric, and approximately equal dopamine releasing properties.

Although as to tolerance, dependence and toxicity... I've been far too occasional of a user of either drug to remotely come close to any, especially the latter considering my extensive stacking with neuroprotective agents. Can't really compare here, but I'd read anecdotes in the 2-FMA megathread of people using it at fairly high doses for extended periods without the typical effects you'd expect from meth.

DexterMeth said:
I'm not going to do it, as I do not use anymore, nor to I support such use; but does that mean if 2-FMA dosage was increased to double that of meth, that the effects would be a lot more alike?
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Subjectively, I'm going to have say no. For example I've done 50mg of 2-FMA, and at a different time 25mg of d-meth. The 50mg of 2-FMA is still a good bit less euphoric, and feels a lot "cleaner" as far as lack of side effects, with the exception of bruxism, which for some reason is a bit more pronounced for me.

It is probably closer to the properties of d-amp, but I'd still rank d-amp as a bit more euphoric than a doubled dose of 2-FMA to compensate for the l-2FMA content.
 
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tweex said:
Subjectively at least, 2-FMA feels like an extremely weak dopamine releaser in comparison to MA, even taking into account the fact it is racemic. I'd rank 50mg of racemic 2-FMA to be approximately as euphoric as 5mg of d-meth (~90% purity), or roughly 5 times less euphoric for the more active dextro isomer.
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I haven't noticed anything of the sort. You subjective assessment might be idiosyncratic, providing little generabilizability to rates of monoamine release. Besides, in terms of SAR, why should 2-fma really be a weaker releaser than MA? The robust effects of other fluoroamphetamines suggest retention of efficacy versus the parent compounds, suggesting retention of activity at transporters. The 2-fluoro substitution does not make the molecule less lipophilic, so 2fma should retain MA's poetency via that characteristic and also readily diffuse into neurons, suggesting the possibility of wreaking damage in that way postulated to play a large role in MA's neurotoxicity.

ebola
 
So assuming that 2-FMA is still fairly neurotoxic, would low daily oral doses (15-30mg) be very harmful to my mental health?
 
It would certainly be much safer to use small, sub-50mg doses if you are going to use it regularly, rather than 100mg+ "party doses".
 
So I have some serious, debilitating, concentration and lethargy issues. I have to take some medicines for some neurological issues that I just can't stop, at least not any time in the future. It's really fucking with my life. It's fucking with my life so bad I'm actually willing to take the risk of using 2-FMA a couple times a week.

This is a really, really, really bad idea, isn't it? Like I said though, it's getting so bad that I'm almost willing to take this risk. Oh, and I've tried talking to my doc so many times and he refuses to prescribe a medicine to treat the side-effect of another medicine.
 
It depends on whether or not you're on something like an antidopaminergic, which taking amphetamine would severely reduce the efficacy of.

Tried caffeine? Or reducing your medication dosage?
 
Caffeine wakes me up but it doesn't get me going or focused and unfortunately I can't reduce my medication even a little bit. This is so damn frustrating. Adderall has worked in the past, so has ritalin, but I can't get a script for either and I'm not going to pay ridiculous black market prices for each pill.

Not on any antidopamine (or whatever) drug
 
sekio said:
racemic 2-fluoromethamphetamine has about equal potencies for releasing monoamines as racemic methamphetamine. So expect similar issues with tolerance, dependence, toxicity etc.
Click to expand...
Somebody told me that 2-FA is not as potent as the same amount of adderall in milligrams because subjectively he is not as "tweaked out".
I thought that 2-FA is practically similar to pure regular amphetamine when it comes to neurotoxicity and potency.
So my advice was to never go over 20mg 2-fa to avoid neurotoxicity as much as possible.
Would you say I am right with that advice?

Adderall should be kind of a mix (I dont know it by heart) of the two ismomers maybe more dextro than levo but it shouldnt be that different from the racemic 2 fluoroamphetamine.
It probably releases neurotransmitters in a different ratio but thinking its safer in higher doses because it doesnt get you as high is probably a subjective feeling.
 
Somebody told me that 2-FA is not as potent as the same amount of adderall in milligrams because subjectively he is not as "tweaked out".
I thought that 2-FA is practically similar to pure regular amphetamine when it comes to neurotoxicity and potency.
Click to expand...

2-fa is a bit more selective for NE than amphetamine, and it does seem slightly less potent than adderall, as RC preparations are almost always the racemate. Also take note that 2fa and 2fma are not the same thing.

sekio said:
100mg+ "party doses".
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So everyone knows, this dose would likely be high enough to make a non-tolerant user fee panicky, or at least physically uncomfortable. I have quite a bit of acquired tolerance, and I would never take this as an attack dose.

ebola
 
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