Draven26
Bluelighter
Been clean for 2 years and I sleep 14 hours a day and don't feel motivated but more suicidal. Is that normal?
Been clean for 2 years and I sleep 14 hours a day and don't feel motivated but more suicidal. Is that normal?
Yes-Meth directly effects the amount of dopamine released within your brain along with of course neurotransmitters etc etc . Depending upon how long one has used or even the amount consumed during one's lifetime will damage these receptors which tell the brain to be "happy". Some people are naturally born with a chemical imbalance or experience Depression. Drug use will also, especially meth, have a huge affect on this.
If possible I would go and see either a local doctor and a therapist. Your brain might not heal from the damage caused or another blatant reason would be 'cause you're having suicidal thoughts. You don't need to tell the doctors you've used, just stick to how you feel and for how long. Trying to figure out just why exactly doesn't resolve anything, it'll actually make it worse because then you're always thinking about the problem itself which can adhere one to "live in the moment". The present is what counts. Go talk to someone about your feelings and see what you can do to help your mind and thought process.
Want to avoid psychosis? Don't. Binge. It is nearly impossible to induce psychosis if there are more than 5 hours of sleep between dosages unless you were already genetically predisposed.
A very important guide for all amp users
2. Pre-treatment. Holy fuck I was glad to find out about this before I started using. Pre-treatment takes only one week and it permanently boosts all your subsequent amphetamine effects. It is called sensitization or reverse-tolerance. When taken at sub neurotoxic dosages, the brain becomes supersensitized to all subsequent amphetamine dosages. This effect has been tested to last longer than 120 days and is probably permanent. Animals were intially given a single small amphetamine dosage. In 120 days, they received their second dosage and the effects were dramatically boosted. Tests in human subjects show that the subjective high is nearly doubled from baseline. More research has shown that the optimal pre-treatment schedule is 0.15mg/kg daily for 7 days. The longer the withdrawal period after that, the stronger the effects (up to 30 days when it levels out). Also, did I mention that pre-treatment significantly reduces neurotoxicity in subsequent binges and high dosages? If your first few amphetamine uses were high dosage, you shocked your brain. You most likely had neurotoxic hyperthermia which diminishes sensitization.
Methamphetamine's addiction potential is equal to prescription dextroamphetamine (at similarly potent doses).
Care to elaborate? This isn't really the kind of thing that you can have an opinion on, but everyones different. Please, do tell exactly what causes you to disagree. Also, to everyone asking about the links; I'm sorry, but again, im not the writer of this post. I took this from a forum that isn't normally accessible from the surface internet. It goes through a service that hides the ip of the website, so it wont come up in search results on a typical browser. Because of this, I decided it deserved to be posted here, where you don't have to be a computer wiz to view it. But sence its out there, i might as well give the link to the original post. There is information to be taken away from the discusion. http://dkn255hz262ypmii.onion.to/index.php?topic=22378.0Disagree entirely.
A very important guide for all amp users
Alright, I dont know know if this is somewhere on this forum, i searched it and found nothing. This is taken from a drug based forum that is somewhat difficult to access. The OP tookall of this information from published studies and amassed this amazing post. So here it is:
1. First off, Methamphetamine is only psychologically addictive. Just like Cannabis, food, or the internet. Methamphetamine's addiction potential is equal to prescription dextroamphetamine (at similarly potent doses). If you are wondering why d-amph addicts are so much rarer, it's because d-amph is typically given out in prescription tablets only. People can still break it down and snort it, but the difference is that these prescriptions regulate their dosage every month and drastically lowers the chances of addiction. Just another reason why the drug war is such a failure really. European speed is so diluted and cut that I'd be surprised if you even got 10% dextro in your powder. No American dealer wants to sell dextroamph because it takes an extra step in synthesis and is less potent. If Europe had the availability to meth precursors like America did, absolutely NO dealer would be selling l- or d-amphetamine. Pharmaceutical companies have the incentive to use d- and l-amphetamine because meth carries such a stigma that patients won't want to take it. Big pharma has near free access to precursors and laboratories so making the slightly less potent d-amph costs almost nothing to them. It is saddening that people who are "pro-drugs except for meth" are tricked by the same misinformation that they hate so much when it's against cannabis. Hopefully by this point, you and I are on the same page and have moved past this "evil meth" label. Thus, I will refer to meth as amphetamine from now on.
Significant withdrawal effects only occur when amph is continuously redosed in high dosages. Why? Because constant redosing causes neurotoxicity. The long half life of all amphetamine means that redosing will additively increase blood plasma levels and your brain will soak in that. Acute tolerance shuts out euphoria around the time you reach your first half life. Redosing = excitotoxicity and accumulation of oxidative reactive species in the absense of most of the euphoria. Daily usage is only safe at therapeutic dosages (UNDER ~0.5mg/kg). It seems like it is generally agreed upon that meth is more potent weight by weight than dextro (about 1.3x). When the dosages are matched, they have the exact same safety profile.
Chronic use at anything above therapeutic level causes persisting DA striatal depletion. As in, it comes back VERY slowly (think years) and it isn't 100%. You can withdraw from Heroin and get away without lasting physical damage. The same cannot be said for amphetamines. The striatal depletions go unnoticed by binge users until they stop dosing whereupon shit gets real. Quickly. These are the only people that get severe withdrawal effects and feel extremely addicted. Just like every other drug, binging is bad. Before you call therapeutic dosages too pussylike, read the rest of my post.
2. Pre-treatment. Holy fuck I was glad to find out about this before I started using. Pre-treatment takes only one week and it permanently boosts all your subsequent amphetamine effects. It is called sensitization or reverse-tolerance. When taken at sub neurotoxic dosages, the brain becomes supersensitized to all subsequent amphetamine dosages. This effect has been tested to last longer than 120 days and is probably permanent. Animals were intially given a single small amphetamine dosage. In 120 days, they received their second dosage and the effects were dramatically boosted. Tests in human subjects show that the subjective high is nearly doubled from baseline. More research has shown that the optimal pre-treatment schedule is 0.15mg/kg daily for 7 days. The longer the withdrawal period after that, the stronger the effects (up to 30 days when it levels out). Also, did I mention that pre-treatment significantly reduces neurotoxicity in subsequent binges and high dosages? If your first few amphetamine uses were high dosage, you shocked your brain. You most likely had neurotoxic hyperthermia which diminishes sensitization.
Source of pretreatment on sensitization and reverse tolerance: http://deepblue.lib.umich.edu/bitstream/2027.42/26144/1/0000221.pdf
Source of pretreatment on neurotoxicity: http://www.nature.com/?file=/npp/journal/v28/n10/abs/1300247a.html
Bonus source for one dosage causing lasting sensitization: http://www.neuro.cjb.net/content/19/21/9579.short
(please keep in mind these dosages in the article are for rats and NOT for humans)
3. Any tolerance to amphetamines that last longer than 5 days is caused by neurotoxicity. The main reason for amphetamine's tolerance is its half life and how quickly the body adjusts to the presence of amphetamine in the blood. After only 3 days (approximately 5 half lives, i.e. ~97% of the drug is gone), this tolerance should be almost completely gone. Any persisting tolerance after 5 days was caused by striatal DA depletions as well as downregulation of D2 receptors. Again, if your tolerance lasts more than 5 days, reconsider your amount and frequency of dosage. Repeated high dosages without adequate time in between will fuck up your shit. The rewarding effects of sensitization is also severely diminished by this binge use.
Source: http://www.sciencedirect.com/science/article/pii/S0278584602002579
(I've seen several other sources but this is one I found with a quick search)
4. If you enjoy higher dosages, you must spread them out. This goes back to my last point. Moderately high dosages can actually be safe given that you washout the drugs (about 5 half lives) before redosing.
5. If you are female, the effects of amphetamine neurotoxicity are two folds stronger and psychosis along with addiction potential occur at half the dosage for males. The presence of certain male androgens are neuroprotective against amphetamine. Sorry, women.
6. Smoking and IV have the same safety profile as other ROA's when dosages are matched for bioavailibility and may actually be safer because of their shorter half lives. Rats can take single 25mg/kg injections with no neurotoxicity because their amphetamine half life is only one hour compared to the human time of 9-12 hours. Amphetamines are one of the rare drugs where these ROAs are safer because amphetamine neurotoxicity is primarily exacerbated by the time it stays in the body. Unfortunately, binge use with smoking or IV causes half life to be irrelevant and the safety profile becomes much more dangerous.
7. If you binge, STAY out places that are hotter than room temperature! Heat literally multiplies the tolerance and deficits you are causing to your brain. And, you must have already caused a lot of deficits if you are dumb enough to be a binge user.
To sum it up, DON'T FUCKING BINGE!
8. If you have suffered psychosis from amphetamine, I would consider stopping usage. Forever. And yes, even if it only happened once. The implications from psychosis are more than just some temporary effect because you didn't sleep. Amphetamine psychosis is actually caused by the repeated dosage - sleep deprivation only made your brain more vulnerable. The variables that play into psychosis are so wide that studies have yet to really be conclusive on them. Currently, it is believed that prolonged amphetamine blood plasma induces dopamine hyperreactivity. Guess how schizophrenics are diagnosed? Dopamine hyperactivity. Again, this probably causes lasting deficits.
Want to avoid psychosis? Don't. Binge. It is nearly impossible to induce psychosis if there are more than 5 hours of sleep between dosages unless you were already genetically predisposed.
Here's the schedule a beginner should follow for daily productive use and to prevent neurotoxicity (Assuming 99% bioavailability. Adjust dosages for your ROA bioavailability):
Days 1-7: 0.15mg/kg
Days 8-?: <0.5mg/kg for males, <0.25mg/kg for females
No more than once a day
For recreational use:
Days 1-7:0.15mg/kg
Days 8-?: <1.0mg/kg for males, <0.5mg/kg for females
No more than once every 3-4 days
After pretreatment and sensitization, 1.0mg/kg WILL bring a satisfying rush. On a 160 pound person, that would be about 72mg. If it sounds too little to you, than you have gone too far.
It's that simple. Moderation is key, what a surprise huh? If everybody took amphetamines responsibly with milligram scales, we would probably be exploring the universe by now.
P.S. As a bonus, take Vitamin C and E for antioxidants. Take Magnesium to slow down acute tolerance (NMDA antagonist = be higher for longer! YAY). Zinc supplementation was also found to be synergistic with amphetamine in ADHD patients. I don't know its effects on normal people, but I take it anyway. For further reading, look up "Robinson TE". He is by far my favorite researcher. Another goodie is Carl Hart. He is a forerunner on meth research and always talks about the exaggerated claims on meth. He himself said that scientists have known for a long time that methamphetamine is exactly like dextroamphetamine at a drug policy conference.

I have always wondered why I had always enjoyed and been able to manage my methamphetamine enjoyment, even when I had a fantastic supply of it. I administered all kinds of ways to.
But this makes sense.
My first experience with methamphetamine was with a woman I had just met who turned me on to smoke it with her. It was fucking amazing, but after that, I didn't know where to get it, and had since resigned it to a once-in-a-lifetime experience. Six months later I ran into a long-term supply and found myself using just as often as my cohorts, but maintained my conscience throughout, while I watched everyone change around me. Maybe it was the neurotoxicity.
Care to elaborate?
That was extremely helpful about what I needed to know. I hope I never do this drug especially because my I know I could come across it when having ADD.
dextro-Methamphetamine is a lot more addictive than regular dextro-amphetamine. This can be accounted for by the relatively stronger euphoria methamphetamine delivers, and is probably related to the 5-HT release that regular amphetamines don't deliver on equally.
I think that most people with equal experience with meth and regular amphetamines can explain how much more addictive methamphetamine is.
I'd be interested to see if it was just me, but I'd be shocked if that was the case.