Codeine and CWE Megathread - The long awaited!

[pinkanga]

Yeah I hear you. Its more just a habit I got into that I really havent sat done and reconsidered for a while. I really should and will stop doing it. I mean every time I do a cwe and I dump the white glump of shit into the toilet after filtering I always think how grateful I am that all that gunk isnt going through my body. And even in the past when Ive cwe'd 10+ pills the results white gunk that I flush down the toilet is still quite substantive, and yeah there really is no need to put that shit in my body eh?

Consider me reformed as of tonight.

 

[Crankinit]

Yeah it's really worth it man, I've popped far too much ibuprofen in recent years and the result is very regular stomach aches, hardly debilitating but not fun either

 

[pinkanga]

Well part of the reason I was maybe a little too blasé about popping 10 as a preload to drinking a cwe liquid solution I too popped waaay to many ibu/cod pills over the years. A stupid irresponsible crazy dumb thing to do. Thankfully everything things to have checked out health-wise... but why push your luck hey?

I tent to justify certain shit because Im a regular exerciser. But exercise isnt a cure-all, prevent-all activity. It certainly helps but its not some magic golden ticket to allow you to abuse the fuck outta your body.

 

[tyrael]

Either chemist's own or panafen are the best brands for me. Cheap and dissolve easily, and usually available in the larger box sizes.

Agreed! Out of the two however I've found the highest return from the Panafen+ - I generally don't even crush up the pills, just put them in a container and shake vigorously.

^ It is extremely widespread among pharmacists. Though in a recent quarterly aimed at Australian pharmacists, they mentioned that there was a lecture at which a pharmacologist discussed the pointlessness of this recommendation given the mechanism that the irritation and damage occurs through. There are some unverified claims on Wikipedia that the slight acidity of these compounds may cause direct irritation, though this is hard to believe given the pH contents of the stomach (around pH 1-2).

I have heard this also. Actually, from the people I've spoken to and the studies I've read, I'm generally getting a 50/50 response of "yes, you should eat" v. "eating really has no effect".

....
But as I was saying, eating before taking ibuprofen won't protect your stomach. The actual damage occurs later once the drug is in your system and inhibiting the the COX enzymes. This results in reduced inflammation, but also inhibits the creation of new gastric mucosa which can lead eventually to ulceration of the GI tract.

Having said that, the inhibition of the production of prostaglandins (causing the reduction in gastric mucosa) the simple act of eating can itself kick start the body in producing additional mucosa (and this maybe [more then likely? ] an over-simplification so don't get me wrong, I'm quite well aware of the complexities of the digestive system and peripheral components :D)

So again, I'm personally 50/50 on a (seemingly) simple topic.

 

[Crankinit]

Strangely, I have always found that eating beforehand reduces stomach ache, and even when stomach ache kicks in, eating a meal will reduce it.

Placebo effect?

 

[Sustanon]

Have any of u guys thought about the long term side effects of CWE usage throughout the years on an almost day to day basis? Been using it for many years and kind of worrying me. What do u guys think? I know paracetamol/ibuprofen isnt good for u but pretty sure other non actives end up in ur CWE which may cause long term health problems. Thoughts?

 

[tyrael]

Have any of u guys thought about the long term side effects of CWE usage throughout the years on an almost day to day basis? Been using it for many years and kind of worrying me. What do u guys think? I know paracetamol/ibuprofen isnt good for u but pretty sure other non actives end up in ur CWE which may cause long term health problems. Thoughts?

Thought has crossed my mind also once or twice! Long term use of - even if in low/therapeutic doses - ibuprofen will have negative effects.

I personally wouldn't be too worried about the other (inactive) ingredient. By definition, they inactive so shouldn't pose any risk.

Having said that, I can't provide ya with peer-reviewed papers or the like at the moment mate, Sus. So it's pretty much going on my knowledge/experience/etc.

 

[footscrazy]

I've sometimes wondered whether taking antihistamines everyday is bad long term.

 

[Crankinit]

I've sometimes wondered whether taking antihistamines everyday is bad long term.

I've wondered the same thing from time to time. I have noticed that continuous use of promethazine can lead to an edgy, uncomfortable state of mind, I can never use it for more than a few days without swapping to doxylamine.

 

[Mr Blonde]

Have any of u guys thought about the long term side effects of CWE usage throughout the years on an almost day to day basis? Been using it for many years and kind of worrying me. What do u guys think? I know paracetamol/ibuprofen isnt good for u but pretty sure other non actives end up in ur CWE which may cause long term health problems. Thoughts?

I used codeine via CWE almost daily for about three years before getting a liver function test. Came up fine. Was low in B12 though, which was unrelated. Due to some unfortunate news from a good friend recently though, and given my large tolerance, I am considering getting another test.

I've sometimes wondered whether taking antihistamines everyday is bad long term.

Long term use of first generation antihistamines can lead to movement disorders similar to those seen with antipsychotics; e.g. tardive dyskinesia and very rarely neuroleptic malignant syndrome. A medical professional has advised me that long term use can also lead to increased blood pressure due to fluid retention, and that this is particularly a problem for those who already have hypertension.

 

[footscrazy]

^ No good A did a quick search and saw promethazine was associated with tardive dyskinesia; is dimenhydrinate also a risk of it? It metabolises into the 1st gen antihistamine diphenhydramine doesn't it, so I'd guess so? Scary. I've taken travacalm everyday for 6 months or so, I didn't realise that was a risk at all... :/

 

[mangs]

I find that smoking a cigarette kills my codeine buzz. Is this normal?

Did a CWE today, was feeling good smoked a ciggie after around 30 mins, While I'm smoking it boosts the high but once I finish the smoke the high seems to drop way off.

 

[pinkanga]

I used to find that smoking a ciggy really brought on any codeine effect I was feeling. At the time my codeine tolerance was pretty low so whether or not that had anything to do with it I dunno. (this was back in the mythical splittable Nuro + days). It even used to bring me to the point of vomiting. So much so that I generally avoided having a smoke on codeine although I always found myself tempted for whatever reason.

 

[pinkanga]

Did a CWE today, was feeling good smoked a ciggie after around 30 mins, While I'm smoking it boosts the high but once I finish the smoke the high seems to drop way off.

Just noticed this part of your post. Interesting. Ill have to try it. It totally wouldnt surprise me if I was to experience something similar. Hows your codeine tolerance? I can see this effect happening to people with a high tolerance where the effect of the codeine can sometimes be somewhat subtle to say the least. A big nicotine head rush would magnify any opiate high you were feeling and the resulting baseline subtlety that you return to after your smoke would be much less pronounced than what it was before the cigarette.

A coupla' (small) hits of mary jane is always a good thing. Less is definitely more though. Absolutely, less is more, so easy to overdo it and all-of-a-sudden youre in the land of introverted self-examination with no possibility of escape other than smoking a fair chunk more weed so youre so blitzed that you pass out.

But I digress. Just had 3 xanax with 500ml grape fruit juice after abstaining from food stuffs all day.... Im probably feeling a little bit talky

 

[Crankinit]

I can't see why it would, especially if you're only smoking once the codeine has already kicked in.

 

[Mr Blonde]

^ No good A did a quick search and saw promethazine was associated with tardive dyskinesia; is dimenhydrinate also a risk of it? It metabolises into the 1st gen antihistamine diphenhydramine doesn't it, so I'd guess so? Scary. I've taken travacalm everyday for 6 months or so, I didn't realise that was a risk at all... :/

There is no metabolism involved; dimenhydrinate is simply diphenhydramine ionically bonded to 8-chlorotheophylline (think of it like table salt, NaCl; they are not physically bonded [known as covalent bonding] but rather simply attracted to one other due to electrical charge). When ingested, it simply dissociates into the component ionic compounds.

Promethazine was originally (or very early on) used as a treatment for psychosis as it does have some anti-dopaminergic activity, though not as strong as as chlorperazine. Still, if you are at risk of these dopamine related disorders then promethazine may be a bad choice.

This study (PubMed abstract) showed that administration of diphenhydramine reduced akathisia in patients who were administered prochlorperazine. Wikipedia states in a bit of one article that diphenhydramine is associated with tardive dyskinesia and related movement disorders, but there were no references and from what I know diphenhydramine does not have the dopamine antagonism activity of promethazine. If you like, tomorrow I can do some more in-depth research when I have access to eMIMS and more text books on pharmacology. Most of the texts I have are from the 70's... but you'd be surprised how little has changed in pharmacology since then.

I find that smoking a cigarette kills my codeine buzz. Is this normal?

Did a CWE today, was feeling good smoked a ciggie after around 30 mins, While I'm smoking it boosts the high but once I finish the smoke the high seems to drop way off.

This is because the intake of nicotine temporarily boosts dopamine levels and adds to the already higher dopamine levels present after ingestion of the opioid. I don't notice a complete drop off; instead I notice a boost from the cigarette and then after five minutes or so back to normal.

As for pinkanga's post about smoking on opioids and vomiting... well, they are both capable of being potent emetics. Add the two together and you can be in trouble. I'm a chain smoker, will go through two packs in a day but have to cut back when indulging with the codeine.

 

[pinkanga]

Interesting.

Fortunately for me smoking is not one of my vices.

 

[drug_mentor]

I always find smoking tobacco increases my opiate high for a period and then I drop back to where I was before I lit the ciggie. I have never noticed a drop in effects anymore than the temporary increase in intensity fading. I remember when I first started doing high doses of codeine regularly I often would have to butt out a smoke half way through due to nausea. I actually am a smoker who rarely smokes ciggies (get enough nicotine from bongs), but I always smoke heaps on codeine. Even the whole day after a night I dose CWE I will smoke a lot more tobacco than I would normally.

 

[Mr Blonde]

^ I am the same with smoking the next day; with the afterglow, a coffee and a few cigarettes I'm set.

 

[drug_mentor]

^ Fucking oath, caffeine is the other thing that I tend to find much more pleasurable during opiate afterglow. There is undoubtedly great synergy between the three drugs.