Misc Hexobarbital

[crOOk]

I guess that's how tastes/biochemistry differs. A good dose of Hexobarbital (and it surely was good dose, whole fucking gram) made me feel like half a gallon without the euphoria. I drink 300ml 80 proof on an empty stomach and I feel te most intense relaxation money has ever bought me for roughly 30mins. Then I get heavily depressed, even suicidal sometimes, self conscious, slightly anxious which lasts for almost a day unless I keep drinking in 30minute intervals (which really isn't hard to do, even for days or weeks once I get started like this, even with my obligations. I managed passing all medicine exams during my last episode). Also the motor skill impairment seemed a lot worse than what I get off my booze sweet spot (downing around 120ml cut ethanol on an empty stomach). Maybe it's just hexobarbital, mabe all barbs are like that for me.

@CrookieMonster
Man don't make me feel worse than I already do about it. I even threw the empty vial away in my barbiturate stupor. Should've sent it to some of you barbiturate enthusiasts or at least given it to my downer enthusiast friend. He enjoys everything that gets you stoned, huge amounts of benzos day by day, even Seroquel gets him off I think lol. But that's probably cause of the gram of coke he goes through in a day. :/

 

[Secobarbital]

I guess that's how tastes/biochemistry differs. A good dose of Hexobarbital (and it surely was good dose, whole fucking gram) made me feel like half a gallon without the euphoria. I drink 300ml 80 proof on an empty stomach and I feel te most intense relaxation money has ever bought me for roughly 30mins. Then I get heavily depressed, even suicidal sometimes, self conscious, slightly anxious which lasts for almost a day unless I keep drinking in 30minute intervals (which really isn't hard to do, even for days or weeks once I get started like this, even with my obligations. I managed passing all medicine exams during my last episode). Also the motor skill impairment seemed a lot worse than what I get off my booze sweet spot (downing around 120ml cut ethanol on an empty stomach). Maybe it's just hexobarbital, mabe all barbs are like that for me.

@CrookieMonster
Man don't make me feel worse than I already do about it. I even threw the empty vial away in my barbiturate stupor. Should've sent it to some of you barbiturate enthusiasts or at least given it to my downer enthusiast friend. He enjoys everything that gets you stoned, huge amounts of benzos day by day, even Seroquel gets him off I think lol. But that's probably cause of the gram of coke he goes through in a day. :/

The comparison to alcohol was just an easy way to explain it. Hexobarbital may have not had any euphoric effects from it to the beginning. Seconal is considerably longer lasting. They basically make you feel numb, anything that requires concentration and dexterity is impossible, you will probably fall a few times. Someone asked me if I was dying once lol. Had I found that vial I wouldn't have been able to find a vein fast enough. I don't know how to put a finger on it except to say I thought it was the best feeling ever. I've only ever done seconal, and haven't seen one in a time when I IV'ed. I know the margin of safety is small on them. 10 unit's in you feel great, 20 units later you are dead and there's nothing they can do. It should set the standard on how dangerous that territory is to say that seconal disappeared from the market b/c it's the doc for physician assisted suicide in Oregon. My old man was getting them to sleep until they passed that law, and Eli Lilly sold the production rights at the same time. I have heard they are back on the market, but exceptionally hard to find. My pops got every seconal from every pharmacy within a 2 hour drive......

 

[crOOk]

Aw man, that sucks for your pops. That being said, I feel a lot less sorry for you not being able to IV your favourite downer anymore, but there's a minimum of empathy for that situation even. ;P Sounds like you had a blast with the stuff. I could imagine this being some people's thing, I went on a 5 or 6 day ether binge before and only slept when I was fortunate enough to pass out. That stuff makes you so apathic you won't even care about the mucus on your chest... until the headache hits, then there's one thing only on my mind. MOAR ETHER! Maybe that'd be a good replacement for you, surely it can be IV'ed if you don't care all that much about your endothelial cell membranes lol. ;P Just be warned, huffing it had me smell like a chemical factory for a day, iv'ing might do the same, not sure how its metabolized and excreted to be honest. *blush*

 

[crOOk]

Today I was thinking about how motherfucking wasted I was the day before yesterday. I can really see how some people would enjoy this and eventhough it's over I'm starting to feel like I'd wanna repeat it. It could just be because I won't see it again anytime soon (should have at least taken a picture, "Soviet Hexobarbital made in the DDR"), but I should note that I've always spoken very low of ether as well and that one definitely has it's upsides. So does any inhalant I guess, but the downsides are quite pronounced. With it's easy availability, I'm surprised it's not more popular lol...

"Sudden sniffing death"

Inhaling butane gas can cause drowsiness, narcosis, asphyxia, cardiac arrhythmia and frostbite. Butane is the most commonly misused volatile solvent in the UK and caused 52% of solvent-related deaths in 2000. By spraying butane directly into the throat, the jet of fluid can cool rapidly to −20°C by adiabatic expansion, causing prolonged laryngospasm. Some inhalants can also indirectly cause sudden death by cardiac arrest, in a syndrome known as "sudden sniffing death"[21] The anesthetic gases present in the inhalants appear to sensitize the user to adrenaline. In this state, a sudden surge of adrenaline (e.g., from a frightening hallucination or run-in with the law), can cause a fatal cardiac arrhythmia.[22]

Furthermore, the inhalation of any gas that is capable of displacing oxygen in the lungs (especially gasses heavier than oxygen) carries the risk of hypoxia due to the mechanism by which breathing is triggered. Since reflexive breathing results from elevated carbon dioxide levels, rather than depressed oxygen in the blood, breathing a concentrated, relatively inert gas (such as the computer-duster tetrafluoroethane or nitrous oxide) will allow for adequate elimination of carbon dioxide from the blood, meaning that there are no outward signs of suffocation even when the brain is undergoing hypoxia. By the time the full symptoms of hypoxia appear, it may be too late to breathe without assistance, especially if the gas is heavy enough to reside in the lungs for extended periods. Even completely inert gasses, such as argon, can have this effect if oxygen is largely excluded (e.g., via a mask).

But back on topic, I think the Tramadol really got metabolized differently, I must've had 100mg that day and it felt a lot like the Tramadol was potentiated. Not just a little bit though. How does this feedback P450 upregulation work? Does it specifically stimulate the liver cells to synthesize a single enzyme. From what I know the cells undergo obvious changes in morphology if they're exposed to large amounts of the drug. I guess it should just selectively induce one gene transcription and even if 2D6 somehow got induced, I don't know how fast that would work for more Tramadol to be converted that's already floating around in my bloodstream. The stuff lasts forever for me anyway, like 18h building up for a solid 6 or 7 hours.

 

[adder]

Comparing secobarbital or pentobarbital to this is rather ridiculous in terms of abuse potential. One dose of either is enough to keep one high and there's no need for re-dosing. Besides there's not much of a hangover-like feeling with them the day after as it is with phenobarbital or benzobarbital.

 

[crOOk]

So this has much less abuse potential you're saying or more than the long lasting stuff? I'm not really that familiar with the downer world and to me it seems that most substances with a long half life let me off a lot more gently than those with a short where there is constant redosing. I can see how withdrawals are stretched out for things like Methadon, how it keeps a steady level and allows for more adaptation to the new constant state of intoxication, but then there are things like crack or inhalants and you see people abuse the shit out of that without them even being particularly "nice". I've heard very contradicting things about the abuse potential of long vs short hl. Would be lovely if you as a much more experienced user of downers could clear this up here.

 

[Secobarbital]

Hexobarbital doesn't last as long apparently. Secobarbital lasts ages, I never got to IV any, I know I would. I'm sure since its a sodium salt, it breaks down quite well in water. Might be hard on the veins, and there is no info on how much a unit will hold. I assume a half cc would hold 100mg. I think you misunderstood me though on "no longer being able to IV my favorite drug". I said I would like to TRY IV'ing my favorite drug. The down side is the # of times you have to stick yourself to feel out the water on dosage when doing that. It's a terrible dangerous idea I wouldn't recommend for anyone here without a ton of experience with barbiturates. It's an easy way to die, way easier than oding on H.

@ crook No I don't think you were down on my IV "habit" just so you know, you are on a forum riddled with I drug users though. I only break out the rigs when I have something that is worthwhile with it. 99.999% It goes up my nose or down my throat. If you hand me diludad or morphine though I don't waste my time with other ways.

 

[Fire&Water]

Yeah I'm not too experienced when it comes to downers. This stuff is probably wasted on me and I'm sure a hardcore IV user who's into benzos as well would get some serious euphoria since this is about as hypnotic as it gets. I'm not sure, but considering how it was used in anaesthesia it should be pretty hypnotic. When I do benzos I either feel nothing at all even at pretty large doses (5mg Lorazepam, 30mg Diazepam, 60mg Oxazepam all had me feel nothing at all before) or they just knock my ass out. The only benzo I ever got some euphoria off was Clorazepat (50mg oral) and that was intense as hell! Ended up doing a loooot of stupid shit that day... I don't even wanna get into it lol.

I should also add that I had ~10mg amphetamine phosphate in the morning (I'm extremely sensitive and my body metabolizes it really slowly, probably a half life of 15h.

I'll just leave all these infos in this thread, so if anyone ever gets their hand on the stuff and googles it or searches on bluelight, he'll come up with this. Most valuable information so far is probably that it has hygroscopic properties, never seen anything like that with a pharmaceutical. It was fluffy as cotton candy at first (crystalline cotton candy lol) and within seconds it turned into a small firm piece of plastic like stuff, very sticky. I think I'm repeating myself lol.

Funny thing when we were young in Michigan seconal, tuinals, quaaludes were everywere to be found way before
percs', talwin, nebutals, tylenol 3's, paregoric were way more popular/accesable (before hydrocodone was even available)
now most punks refer to oxy's/hyros' as downers...most of the pharm' speed that was a-plenty were black beauties
desoxyn & the original transparent white cross. Musta' been leftover from the hippy days...

 

[adder]

I'm saying you'd definitely be more prone to getting addicted while taking hexobarbital than while taking phenobarbital or benzobarbital. But then again hexobarbital isn't a barbiturate that gives a full blown narcosis and it doesn't relax muscles as much as other barbiturates so it'd be less physically addicting in theory. Secobarbital, pentobarbital, or cyclobarbital all last much longer than hexobarbital but the feeling they give is much more pleasurable, at least for people who are fond of barbiturates. Like I said, secobarbital, pentobarbital, and cyclobarbital are alright for me (especially secobarbital), but phenobarbital or benzobarbital last too long, their half-life is even 3 days (or sometimes more), while those three aforementioned have at most half-life comparable to clonazepam (cyclobarbital's is 8-17h, the least of all three). Anyway, another very addicting one would be thiobarbituric acid derivative - thiopental, It's brilliant when injected, it's rapid and short-acting.

From what I know, in my country commercially only phenobarbital (as sodium salt in 15mg and 100mg tablets, 200mg/ml ampules, and 15mg suppositories), cyclobarbital (as calcium salt, 200mg tablets), hexobarbital (as sodium salt, 25 ampules with 1g of powder in one packet), thiopental (as sodium salt, 500mg or 1g in ampules). There's also a medicine with amobarbital but it's either combined with aminophenazone or propyphenazone (220mg + 30mg / 440mg + 60mg tablets and in case of aminophenazone/amobarbital there are also ampules for injection 220mg + 30mg). The most widely spread in pharmacies is phenobarbital (for a regular prescription) and that combo medicine with amobarbital (it's OTC). Also, it's easy to get benzobarbital in tablets in Ukraine.

I'm addicted to benzodiazepines and I'm currently on clonazepam. I'm tapering down right now but earlier I sometimes used secobarbital (lab grade powder of sodium salt), pentobarbital (lab grade powder of sodium salt), cyclobarbital (lab grade powder of sodium salt), thiopental (lab grade powder of sodium salt), phenobarbital (lab grade powder of sodium salt, 100mg tabs and ampules) or benzobarbital (100mg tabs) to save some clonazepam. And once I had a package of 25 ampules with 1g of hexobarbital sodium but for me it was very disappointing. I also remember taking barbital, it was very sedating and I needed very high doses.

For me: thiopental > secobarbital > pentobarbital, cyclobarbital > phenobarbital, benzobarbital > hexobarbital >> barbital.

 

[etf]

I'm a retired neuropharmacologist, and in my lab we used prolongation of hexobarbital-induced sleeping time as a measure of sedative activity. I've never heard of hexobarbital being used in any other context. As for dosage range, all barbiturates produce pretty much the same AUC with the same dose -- phenobarb has a slow onset and long duration, while secobarb has a rapid onset and short duration -- but 100 - 200 mg of either one has approximately the same total effect. Remember that barbiturates must be dosed based on body weight, mg/kg, and the dose range I named assumes an "average 70 kg man."

 

[crOOk]

Well welcome to the forum etf! From what I heard it has seen some limited use in anaesthesia as well, specifically it was used to induce anaesthesia or provide a short lasting knockout for quick procedures.
I read anecdotes that it enjoyed relatively large popularity among the earliest used iv anaesthetics, must've been the early 30s with barbiturates first being synthesized decades earlier. Not exactly sure how long this carried on either, but it seems history carries a few examples of risky methods for taking away pain during surgery, at least from today's perspective. There sure has been quite some evolvement in that field. You could probably tell me more, I only know a few scattered bits and pieces.