Opioids Can lidocaine affect the intensity of the hydromorphone rush?

[scottd420]

Well folks, I have a weird situation to report. Please chime in and tell me what you think, any expert advice would also be appreciated.

So, today I went to the dentist to get a filling and the dentist used a 1:1000 mix of epinephrine and lidocaine. After I got home I could feel some of the local resorbing from the tissue which would lead it back into the blood for metabolization in the liver. Beforehand I had prepped a 4mg IV shot of hydromorphone to help kill the pain--which wasn't as bad as I'd remembered.

When I got home I prepped another shot as I have chronic pain. I felt like getting a little buzz, but I didn't expect to get much as I had just taken a shot about two hours previous. Well, when I took the shot I was overtaken by a huuuge rush! It felt like I hadn't dosed all day and had taken 8mg instead of 4mg, even though I had taken 4mg every four hours or so. Anyway, I was shocked and enjoyed the pleasure which seemed to last much longer than my regular shots.
I remembered reading that some heroin distributors cut their product with benzocaine for said reason of increasing the rush(which I don't even know if it boosts the effects or is just a myth). However, I didn't think of this until after the dose so I couldn't have gotten a placebo effect. So, I am wondering if some of the lidocaine in my bloodstream would have somehow increased the potency of the rush from my hydromorphone. The amount of epinephrine in the shots at the dentist was miniscule, so it wasn't the stimulant making it feel stronger. Any information would be great. It just seemed waay too random to be placebo, and I would have had no reason; I was actually expecting the rush to be pretty weak considering I already had some in my system...

 

[snooter420]

there are many things that could have contributed to the nice high. what was your diet tha t i cant day?? are you use to iv.....i cant see the drugs that the doc gave u interacting anyway to help your high. so im curious as to what else it could be. mor info needed form you.....deit,tolerance level, r u a reg user, and did u by chance eat reed meat that day???

 

[scottd420]

there are many things that could have contributed to the nice high. what was your diet tha t i cant day?? are you use to iv.....i cant see the drugs that the doc gave u interacting anyway to help your high. so im curious as to what else it could be. mor info needed form you.....deit,tolerance level, r u a reg user, and did u by chance eat reed meat that day???

Hello snooter, thanks for the reply; I'm also very curious as to what boosted the effects so much.
My diet was the same that day as usual, so it wasn't from absorbtion and displacement from high fat intake. I am a regular user of about 34-45mg IV hydromorphone per day.
What made me interested specifically about lidocaine is the rumors from NYC of distributors cutting their product with benzocaine to enhance the rush. (However, I do realize that this is probably just a myth) I had about the same amount in my system all day from steady dosing, so it wasn't due to half-life or metabolism from P-450 enzyme inhibition, it's just that my shot 4 hours before didn't have a huge rush, but about medium strength compared to a morning shot. however the only different was me being injected with lidocaine, and it was finally coming out of the tissue about the time of injection. I wish I could find an easy answer...

 

[Downloader08]

That's really interesting.. Lignocaine doesn't cross into the central nervous system though and I can't see How any of its actions could increase the rush.. Is there any chance you were given anything else by the dentist as well?
If not that, then perhaps the loss of blood was significant enough to effect metabolism (unlikely though) or maybe there was a accidental dosaging error either by yourself (not criticizing you here, just pointing out possibilities) or in the formulation of the hydromorphone.
Really interesting effect though =P

 

[psychopath]

I am a regular user of about 34-45mg IV hydromorphone per day.

holy shit.

 

[DavisK4high247]

Lidocaine is a local anestetic, but is used for treating heart conditions when used IV, so I doubt that it would make any difference on hydromorhone high. Benzocaine can be taken IV and not cause the same effects as lidocaien does on the heart. I'm not sure what lidocaine is used for on the heart, but I know that it is not something that gives a rush..Also some dealers cut heroin with B12 to give a little "rush" to the dope. B12 actually gives a little rush,and benzocaine would speed up heartrate i'm sure, benzocaine is often used to "cut" cocaine to mimic the numbing effect, but lidocaine is dangerous IV and is rarely used IMO to cut coke or heroin, at least I never have known anyone to cut any drug with lidocaine, but cocaine I have seen cut with benzocaine, and B12, and i have seen heroin cut with B12..

 

[snooter420]

i had some lidocain patches for my back, and i used them up quick because it was good relief without having to use all my oxy...but when i did dose with oxy while using the patches i cant recall any enhanced efffect...
i actually have some dental work coming up so i will experiment with this to try to help u figure out what it was. although im not a IV user so close as i can get is snorting them. i will post back on this thread after and see if i experienced any enhanced effects as well. although it wont be a very accurate test since there are so many variables...
I have been tempted to shoot up d's for a while, but just kinda scared of the repercussions (not being able to go back to eating/snorting the opiates that i am scripted) im gonna add you man, and maybe when i do get the balls up to boot you could help me...I know there is lots of info on here about it, but sometimes its nice to have someone to guide you through it and b able to ask questions 2 .
im on a lot of oxy and when i run out ahead of time(cuz im an idiot) i end up having to pick up d's to avoid withdraw. but there always so worthless just snorting em. i can snort like 24 mg and not feel very high. just keeps me from withdrawing mostly. i get 15 and 30 mg ir oxys. and plenty of them i wished i had more self control and could make my scripts last.
Is it hard to go back to snorting after I.Ving.....I really hate needles and shots prob one of the main reasons i haven't done it besides the danger of it, and the obvious long term health effect.....I given a lot of iv shots to cattle I think i might try it today!... can u get micro filters form walgreens or walmart or other drug stores??? i wouldn't do it unless i had all the tools to do it the safest way. im even thinking about shooting one of my 15'ss since i dont get my 30s till the 20th....*(( hope that info is ok with the blua rules the way i understood them is you are not spose to give the number of pills u get))*
its legal here in NM just to by a rig otc.....i already have a 300 mg a day habit. so would shooting up be beneficial to my stash or just make me a feign. this is not something i wanna do all the time just really wanna try it

 

[snooter420]

i had some lidocain patches for my back, and i used them up quick because it was good relief without having to use all my oxy...but when i did does with oxy while using the patches i cant recall any enhanced efffect...
i actually have some dental work coming up so i will experiment with this to try to help u figure out what it was. although im not a IV user so close as i can get is snorting them. i will post back on this thread after and see if i experienced any enhanced effects as well. although it wont be a very accurate test since there are so many variables...
I have been tempted to shoot up d's for a while, but just kinda scared of the repercussions( not being able to go back to eating/snorting the opiates that i am scripted. im gonna add you man, and maybe when i do get the balls up you could help me...I know there is lots of info on here about it, but sometimes its nice to have someone to guide you through it and b able to ask questions 2 .
im on alot ox oxy and when i run out ahead of time(cuz im an idiot) i end up having to pick up d's to avoid withdraw. but there always so worthless just snorting em. i can snort like 24 mg and not feel vary high. just keeps me from withdrawing mostly. i get 15 and 30 mg ir oxys. and plenty of them i wished i had more self control and could make my scripts last.
Is it hard to go back to snorting after I.Ving. I think i might try it today! can u get micro filters form walgreens or walmart or other drug stores???

 

[amapola]

It very well could be that the drugs had some other effect on your body that simulated a rush and high but in fact wasn't. Hmmm I'm not explaining that well. For example when a shot causes a histamine release it seems "stronger" but is really just the body load.

Another option is the pain in your mouth could have been causing your endorphins to be spiking and that combined with the hydromorphone made something stronger.

I'm afraid speculating about the cause is generally pretty futile with no real answer going to be found. The harm reduction value of this thread is pretty slim as well, but I will leave it open for now as there are likely lots of people who self medicate with opioids after dental surgery and if there was some complex combination here then it would be worth knowing.