I tried putting a CWE of 100ml into my arsehole. A mini enema I suppose, although 100ml might not make it out of the rectum into the colon so maybe that's not an enema. not sure.
I got it all in there, but not very impressed. It seemed to turn the codeine into slow release., so slow as to barely perceive it. Certainly not a 'high'
I say slow release even though I was barely able to perceive it because the next day I had a similar tiredness that I get from normal CWE & as such decided I may have received the full dose only so slow as not to be perceived that night.
Has anyone else put a CWE liquid mix into their arseholes and how was effects in comparision to CWE via oral route on empty stomach?
Would changing the PH of the CWE liquid make a difference to how fast it absorbs?
I think maybe because codeine depends on first pass metabolism so codeine via the rectum does not have a direct route to the liver via the 'hepatic portal system' the liver does either a poor or a slow job of converting codeine to morphine?
from wiki. on first pass
The first-pass effect is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. After a drug is swallowed, it is absorbed by the digestive system and enters the hepatic portal system. It is carried through the portal vein into the liver before it reaches the rest of the body.
The first pass effect can also be exploited for a beneficial effect. Some prodrugs, for example codeine (methylmorphine, inactive) are converted from an inactive form to the pharmacologically active form (morphine proper) by first pass metabolism (in this case, desmethylation)