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The Big & Dandy Methoxetamine Thread - 2nd Dissociation

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Shite that is bad news. I think the lower back problems might be from a dodgy batch from the official vendors.
 
I have used a lot of this compound in the past weeks (via IM) and have not experienced any problems (yet).
 
^ I really hope I am wrong to be honest. There are some nasty flu's going around at the moment which cause stomach aches and lack of grip so it could be related to that.
 
In answer to the questions regarding ROAs IMO plugging is the way with this one! sniffing is ok for a mild session as is oral but there is simply no comparison to a decent 100mg dose plugged.

I havent used this compound IM and tbh don't ever intend to (personal preferance) but 100mg oral or sniffed just dont get me where i want to be however plugged this dose is pure bliss!

onset is about 20 minutes sometimes less and duration almost exactly 4 hours with 2 hours of residual stimulation and rushing thoughts.

I have been using every weekend (250mg over 2 nights in 100mg doses with odd 10mg bumps) for last 5 weeks with zero side effects.
 
ashxcore said:
It was over the course of 3 hours, not 5. The first 50mg were done within an hour, if I recall.

Tell me the reasons you don't think it has any mu receptor action. I'm curious.

No, I've never IM'd ket. I'm not too fond of the idea of using needles, although I am not mortally or morally averse to IMing. IVing on the other hand... I do a lot of substances intranasally so I don't really consider it ineffective or unpredictable.

Sublinqual puts me off because of how the drip upset my stomach like ket does...it's a silly assumption to make, but I'm wondering if it has the same ravaging effects to the stomach and bladder.

As for plugging, it will dissolve in how many ml? I only have 3ml syringes at current.
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Hi....

Well, by old SAR logic and papers, a MeO or HO or amine group or such on the 3 position of the phenyl ring will produce Mu action. Whether or not this action is agonistic or antagonistic or something else has yet to be determined. The MeO group would produce the least affinity, and Hamhurricane reported a friend screening 3-MeO PCP (which we would expect to behave quite similarly to MXE) for MOR agonism and it having none. It is possible MXE is o-demethylated during its metabolism, producing a 3-HO group ,which has been shown via the PCP analog to have amuch higher affinity...whether this is an agonist or antagonist has yet to be determined. At least by me. ;) I've read some conflicting stuff. And we still don't know its metabolism.

Aaaand, on the subjective front, I spent a good chunk (10 years) of my early life addicted to opioids. I know mu agonism like nothing else;) And I've never felt anything remotely resembling any sort of MOR activity with MXE, in doses up to 100mg. Friends report the same. Friends on opioids with varying affinities (heroin, buprenorphine, hydrocodone) report no antagonism either. If MOR activity of any sort is there I think it is insignifigant at the doses people are taking.

Do your self a favor and I.M. ket. That advice is harm reduction. Reducing the harm caused by underestimating the power and potential of ketamine by taking it intranasally. ;) Really, it is profoundly different. That is, if you really like K. if its just a fuck you up party drug for you, don't bother. But if you are after the dissociative-astral-wormhole-rolls royce-psychedelia, you will be amazed. I'm amazed just thinking about it. Seriously, it is easily in the top ten of experiences a human being can have on this planet. And MXE, while not as drastic of a contrast, is also amazingly better via I.M. than any other ROA. Amazingly.

I described intranasal MXE as unpredictable or inefficient because that is what most users are reporting. The N-ethyl group (as opposed to Kets N-Methyl) serves a few purposes. It is most effective for potency (higher than methyl, or just naked, or going the other way to propyl, etc), as can be seen with difference between MXE> K, or PCE > PCP, etc. It also allows the compound to have much higher oral bioavailability, as can also be seen comparing it to ketamine. This N-ethyl group is believed to be cleaved off metabolically, creating the norketamine version of MXE. This nor metabolite is what is believed to be cause the bladder and kidney issues with K, after prolonged periods of mammoth doses. We should expect MXE to behave similarly, but due to its much lower dose, and its self-limiting nature I think we won't see much true cystosis. But we'll see.

Have you tried sublingual dosing? You mention a drip irritating your stomach but you shouldn't get a drip if you are doing it correctly. Not near as much as by intranasal! Well if you don't try it by I.M. , plugging gets very rave reviews, second only to I.M. I've gotten it to go into solution at 100mg/ml without a problem (heating and stirring) but at higher concentrations it precipitated out after it cooled. 50mg/ml works great, and allows for more refined dosing. Lube up that 3ml and start probing the ol' wormhole!

Have fun and be safe:)

By Delsyd

I have yet to try MXE, but i also believe that IM will produce a much nicer experience based on my previous Ketamine experiences.

Ive really enjoyed all your posts on MXE. Thanks for sharing them.
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Of course, glad to be of service! Let us know how your MXE experiences go. I've seen your awed mentions of I.M. ket so I'd love to hear your opinion on methoxetamine.

Cheers:)
 
Unfortunately people in other forums have been referring to this as Mket. Although i've heard no mention of it "on the street" so to say
 
Mercc96 said:
Unfortunately people in other forums have been referring to this as Mket. Although i've heard no mention of it "on the street" so to say
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I've yet to meet anyone else who knows about methoxetamine. It did take meph a good few years to spill out onto the streets, so hopefully MXE will stay quiet for a while.
 
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amanitadine said:
Do your self a favor and I.M. ket. That advice is harm reduction. Reducing the harm caused by underestimating the power and potential of ketamine by taking it intranasally. ;) Really, it is profoundly different. That is, if you really like K. if its just a fuck you up party drug for you, don't bother. But if you are after the dissociative-astral-wormhole-rolls royce-psychedelia, you will be amazed. I'm amazed just thinking about it. Seriously, it is easily in the top ten of experiences a human being can have on this planet. And MXE, while not as drastic of a contrast, is also amazingly better via I.M. than any other ROA. Amazingly.
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Bad, bad influence. I'm considering placing an order of needles.. :) Though, i have tried 100 mg ketamine IM 10 years ago, but it didn't in any way strike me as superior to nasal insufflation of 2-300 milligrams (no tolerance) back then.
 
Mr.Toad said:
how well does it dissolve in water?
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Now that depends on if it's real MXE or not. I'm wanting to know the same answer using real methoxetamine hcl. I would think it would be just like ketamine hcl dissolved in water, it dissolves perfectly. The fake crap I got dissolved nicely with heat but quickly fell out of suspension and solidified, but I know that doesn't help you..
 
I got legit MXE from the big 5. I had no preexisting health conditions except opiate addiction.
 
So did you take the methoxetamine while maintaining on subs or any other medication for that matter?

Lately I have noticed quite a few complaints about "official" methoxetamine that has been ordered after the new year. I don't know if there's any correlation to that and what happened to you but it may be worthwhile to compare some reagent tests from the older batches to the new.
 
unfortunately, since there was an od er call. the police came and ransacked my room and took everything.

i did not exp opiate w/d as i would have previously.
 
@ nanoshot : Sadly can't pm yet, gotta get those posts up! I ordered from an official vendor aswelll though. Was it your first order with the vendor?

Ontopic: Has anyone had any experience combining mxe with mdma? During the peak or on the comedown? Also has anyone tried this in a club-setting?
 
MXE is a no no in a club setting, one guy posted a trip report involving him getting thrown out of a club after groping someone and biting a bouncer or something. But im sure MXE on a comedowns not a bad idea due to the cotton woolishness of it. :D
 
Can we get this bad batch cleared out?

Anyone here who bought from the big5 before and after the sale they have?

I would like to get a few grams while it´s cheap but i dont want to lose my money on shit.

i ordered late november and that batch was awesome<3
 
nanoshot said:
Now that depends on if it's real MXE or not. I'm wanting to know the same answer using real methoxetamine hcl. I would think it would be just like ketamine hcl dissolved in water, it dissolves perfectly. The fake crap I got dissolved nicely with heat but quickly fell out of suspension and solidified, but I know that doesn't help you..
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The original batch also solidifies within a few minutes if dissolved with heat. I have no doubt of it's authenticity. It will dissolve in cold water with some agition but I always use heat as it is quicker and sterilises the water at the same time. Just make sure to shoot it before it solidifies.

Out of interest, what makes you think yours was fake? Did it have any effect at all?
 
I am very worried , last time I have trouble with my breath . I think that it can be asthma . I have problem especially in night . In day is everything Ok . I wanna take 100 mg methoxetamine on the first time but I will begin from 50 mg and I will see reactions on my respiratory.
 
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