• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards

How many of you suffer insomnia? And...

Status
Not open for further replies.
Psychedelic Jay said:
Well we are all in the same boat here. I got three pills left just sitting in my med cabinet, and I think about running out every time I see them...
Click to expand...

That must be tough. I could never save them, I'd munch them up immediately, I have no self control. I'd eat two of them today and save the other for tomorrow night. If you going to just keep them sitting in the med cabinet all alone I'll take em off ya and put them to use. My brain could use a release of GABA right now.
 
K'd-OUT-in-AZ said:
That must be tough. I could never save them, I'd munch them up immediately, I have no self control. I'd eat two of them today and save the other for tomorrow night. If you going to just keep them sitting in the med cabinet all alone I'll take em off ya and put them to use. My brain could use a release of GABA right now.
Click to expand...

No sir, these are like diamonds to me. I keep them in a ring box... LOL

I use them only for comedowns when absolutely nothing else is available.
 
I just got my Rx of Lunesta (Eszopiclone) maybe this could move to an ADD thread but, I was assured by the pharmacist that Lunesta acts differently in the brain than Ambien. I had told here I was wary of paying the HIGH price (mods delete this if its too far) for lunesta compared to other meds I have been Rx'd for sleep when I didn't even know if it would work; Ambien did NOT work for me.

Now I'm not a specialist on neurochemistry but I do a lot of research about sleep drugs, because it concerns me. Can someone tell me if there is a difference between how zolpidem and eszopiclone act on the brain?

I thought they both bind to GABA-A receptors. perhaps its just that Zolpidem (Ambien) binds more specifically to GABA-A (alpha-1)? I thought they were both selective to alpha-1 hence causing sedation/hypnotic effects with very minimal anxiolytic effects
 
Zolpidem and Eszopiclone both act on the benzodiazepine binding site on GABA-A as agonists. They are Z-benzodiazepines so they are selective to the alpha1 subunit. They work the same but can have different effects just like all benzodiazepines work the same but have slightly different effects.
 
mgrady3 said:
I just got my Rx of Lunesta (Eszopiclone) maybe this could move to an ADD thread but, I was assured by the pharmacist that Lunesta acts differently in the brain than Ambien. I had told here I was wary of paying the HIGH price (mods delete this if its too far) for lunesta compared to other meds I have been Rx'd for sleep when I didn't even know if it would work; Ambien did NOT work for me.

Now I'm not a specialist on neurochemistry but I do a lot of research about sleep drugs, because it concerns me. Can someone tell me if there is a difference between how zolpidem and eszopiclone act on the brain?

I thought they both bind to GABA-A receptors. perhaps its just that Zolpidem (Ambien) binds more specifically to GABA-A (alpha-1)? I thought they were both selective to alpha-1 hence causing sedation/hypnotic effects with very minimal anxiolytic effects
Click to expand...

This is a valid question. I had the same impression and am too lazy to do more reading on the subject. I have only tried Zopiclone. It isn't a great drug for sleep or recreation, but I often prefer it to alcohol for both.
When my tolerance was lower, I'd get dygeusia (metal taste) as well. It makes everything hard to eat and feels kind of weird. But I got over it, and it's worth it compared to drinking that alcohol (eww) plus the minor visuals are ok.
 
Psychedelic Jay said:
-You do research on the med you want for your specific claim. (Disorder/ Illness) This will not work for pain medication, if you have no medical record for tolerance, they will refuse to give you stronger meds in a heartbeat.
Click to expand...

Bit off-topic, but, I'll just say when I broke 4 bones in my thumb/hand a ~couple years ago. After being given a script for '30mg codeine/500mg APAP' tablets when I was ready to go home before waiting for the operation I needed (couple weeks later-on). I immediately and politely said I had abused opiates in the past recreationally and the codeine wasn't going to touch the pain. The doctor looked annoyed, probably because I'd told the truth and my opiate tolerance was too high at the time for codeine to help. So he then wrote me a script for 20x 10mg oxycodone IR and 20x 50mg tramadol IR. The doc probably only upped the script to stronger opiates due to him only needing to write the one script knowing I wouldn't be needing any pain killers within a month atleast.
 
the lunesta, as expected, did not help me sleep:
I was rx'd 3mg (the max starting dose according to my doc), I took it at 9:45pm and was in bed at 10pm
don't recall how long ti took to fall asleep, i'd guess less than an hour.
woke up a bit before 2am, wide awake.
so the 3mg of Eszopiclone kept me asleep for maybe 3 hours...

tried taking 0.5 mg Klonopin, still didn't fall asleep
finally took a few puffs on a joint, and another 0.5 Klonopin, moved to the couch, finally fell asleep for a bit less than 2 hours until I had to be awake at 6. felt miserable all morning.
 
puckboy said:
Bit off-topic, but, I'll just say when I broke 4 bones in my thumb/hand a ~couple years ago. After being given a script for '30mg codeine/500mg APAP' tablets when I was ready to go home before waiting for the operation I needed (couple weeks later-on). I immediately and politely said I had abused opiates in the past recreationally and the codeine wasn't going to touch the pain. The doctor looked annoyed, probably because I'd told the truth and my opiate tolerance was too high at the time for codeine to help. So he then wrote me a script for 20x 10mg oxycodone IR and 20x 50mg tramadol IR. The doc probably only upped the script to stronger opiates due to him only needing to write the one script knowing I wouldn't be needing any pain killers within a month atleast.
Click to expand...

It's not for all docs dude. Like you I know those reluctant docs, then the cool docs.
 
l after the lunesta fail, looks like I'll be sticking to benzo's.
I hope to finally get an rx for something stronger for sedation at night.

My psych said, in response to me telling him klonopin doesn't sedate me but helps great with anxiety, "try taking higher doses"

hopefully I can eventually move on to something like temezepam or nitrazepam for nighttime use only.

Does anyone know if you can slow the tolerance build with benzo's by combing them with pot?
If you were certain your pot had sedation/anxiolytic qualities (a la Indica or something crossed with ruderalis) then persay could you replace a 15mg dose of temzepam with say, half the pil (7.5 mg_ plus a few tokes ona joint or better yet from a vaporizer?
 
mgrady3 said:
l after the lunesta fail, looks like I'll be sticking to benzo's.
I hope to finally get an rx for something stronger for sedation at night.

My psych said, in response to me telling him klonopin doesn't sedate me but helps great with anxiety, "try taking higher doses"

hopefully I can eventually move on to something like temezepam or nitrazepam for nighttime use only.

Does anyone know if you can slow the tolerance build with benzo's by combing them with pot?
If you were certain your pot had sedation/anxiolytic qualities (a la Indica or something crossed with ruderalis) then persay could you replace a 15mg dose of temzepam with say, half the pil (7.5 mg_ plus a few tokes ona joint or better yet from a vaporizer?
Click to expand...

No, weed slows down the production of gaba.
 
Last edited:
don't have time to read it all now but that looks like a great article thanks for the share

and by the by, I'm glad this thread has garnered so much attention; we are up to 100 posts now.
I've certainly learned a lot from it.
cheers to all the contributors.
 
Last edited:
Status
Not open for further replies.
Top