So, dude man took 60mg in the form of 2 ms contin 30mg pills today, dissolved in 10cc's off water, and plugged using an oral syringe inserted just far enough not to shoot any out..... He felt nothing
Is there a possibility that his rectal mucous membranes are completely ineffective at absorbing drugs? He used the restroom about 3 hours before plugging, so he was under the impression that feces blocking absorption would be negligible. At t+4 hours after plugging, he had a bowel movement resembling diarrea, ie watery, after trying to hold in it since about t+1 hour when the sensation began to build. He plans on recreating the experiment tommorow, only this time giving himself a 100cc water enema and evacuating that along with any feces DIRECTLY before administration...can he expect markedly better results given that his colon will be significantly more empty? Or, given that at the time of administration today,he didn't have a FULL colon by any means,but obviously not 100% clean, as there were solids in the feces at t+4.... can he expect the SAME results (basically NOTHING)
Would adding alchohol, or perhaps lemon/lime juice to the solution aid in it's absorption?
Please, spare the sarcasm....he just wants the facts
Is there a possibility that his rectal mucous membranes are completely ineffective at absorbing drugs? He used the restroom about 3 hours before plugging, so he was under the impression that feces blocking absorption would be negligible. At t+4 hours after plugging, he had a bowel movement resembling diarrea, ie watery, after trying to hold in it since about t+1 hour when the sensation began to build. He plans on recreating the experiment tommorow, only this time giving himself a 100cc water enema and evacuating that along with any feces DIRECTLY before administration...can he expect markedly better results given that his colon will be significantly more empty? Or, given that at the time of administration today,he didn't have a FULL colon by any means,but obviously not 100% clean, as there were solids in the feces at t+4.... can he expect the SAME results (basically NOTHING)
Would adding alchohol, or perhaps lemon/lime juice to the solution aid in it's absorption?
Please, spare the sarcasm....he just wants the facts
