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Opioids Experiment Thead - New Formulation Oxycodone Extraction

WOWZERS---- CHECK IT CHECK IT CHECK IT what Jaymonk be findin' up in diz =P

"Now let me first discuss the data generated under 18 hours. You see a lot of high ratios. This is understandable. This is 12-hour product. At 18 hours you expect everything should have been released. Therefore, we did not conduct statistics on data generated at 18 hours." pg 96 document #2 from my above post

pg 190 Document 2
"The 18-hour time point for these experiments is included for reference and it’s part of our approach to define the failure limits of the formulation. One has to appreciate that this is a product intended for dosing every 12 hours.
So you’re correct. Should one elect to lay a tablet in a glass of water for 12 hours, to be therapeutic, the oxycodone needs to be released from the formulation."



DO you understand???? All of this SOLVENT talk bullshit was done to experiment with ACCELERATED extraction! Thats all! With enough time (18 hours), Purdue admits all of the oxycodone HAS to be released! That means we should theoritically be able to dump 10 pill in a glass of water, wait 18 hours, remove the slush, and have oxycodone water!!! No chemicals needed =) Than we can evaporate it, mix it with a powder and dry it and have OC powder, or micron filter and slam it, or drink it! Who cares if ti takes 18 hours--- just do a bunch of pills at once, do an extraction, adn farm the resources!

What do you guys think of these findings?
 
^^ nice. I wonder though if it will still be the consistency
of jelly. Not that I would mind, oral ba being what it is.
 
Hey been following this thread for a while... good stuff thanks for sharing! Keep up the good work, Andrew when you evapped your ISO did you really get crystals? And a friend wonders whatsup with the BHT, which part takes care of that? Left behind out of the ISO or done away with in the Acetone? Oh and regarding the 12 hour thing, do you think the extraction would yield a lot more (99 percent?) if you stretched it out over that time, to allow the drug's molecules enough time to escape the matrix? Will you try it? Peace
 
jaystyle said:
Bleach is not a solvent... it is just a hosuehold chemical that disinfects surfaces and bleaches hair and clothes.

Acetone & MEK are industrial strength SOLVENTS that evaporate quickly. the PURDUE website makes it clear they used solvents to extract oxycodone.

Anyone with chemistry background have suggestions of other solvents to try? There are many (turpentine, chloroform, ethyl acetate, etc). Anyone know about the specific bonds oxycodone has to the polymers so we can figure out how to break them with appropriate solvents? How much time could we let these pills sit in these solvents without risking the alkaloid breaking down?

ALSO: Please stop wasting out time with bullcrap unrelated posts (ETHEX generics, EATing OPs, random bullshit). Go back to the other thread if you want to waste time, this thread has a specific purpose so stick to it or go elsewhere.
Click to expand...

You don't understand how it works. Chemists like myself are not idiots. We already tested if the polymer is soluble in other solvents and it's not. Why do you think we picked a plastic? Because plastics don't react with anything.

This is a special type of plastic. A good idea woulf be to simulate what goes on inside the body...using aqua regia won't do the job lol.

P.S. bleach is a solvent.
 
Making a blanket statement saying plastics don't react with anything is just plain wrong. And
if u r saying water won't break down hypromellose, again, ur just plain wrong. The whole time release mechanism is based upon the hydrolysis of the hypromellose, which
is a rate limited, ph independant, chemical reaction. U think the people on here
have no chemical knowledge. I have been reading and posting for some
time now and I can attest a good many have presented options using sound
scientific reasoning.
 
cvalero said:
U think the people on here
have no chemical knowledge. I have been reading and posting for some
time now and I can attest a good many have presented options using sound
scientific reasoning.
Click to expand...

like the guy who wants to use bleach to dissolve the pill? ^.^
 
^^ the principle behind bleach is actually a good one. Hypromellose is very unstable in the presence of a strong oxidizing agent. That being said, the toxic nature of bleach and the presence of bht (antioxidant) would make using bleach less than ideal. Nevertheless, this is an open problem solving forum whereas ideas are shared and discussed. I would hate for someone with a solid idea to withold it out of fear of being ridiculed.
 
cvalero said:
^^ the principle behind bleach is actually a good one. Hypromellose is very unstable in the presence of a strong oxidizing agent. That being said, the toxic nature of bleach and the presence of bht (antioxidant) would make using bleach less than ideal. Nevertheless, this is an open problem solving forum whereas ideas are shared and discussed. I would hate for someone with a solid idea to withold it out of fear of being ridiculed.
Click to expand...

Here's how I see it. One must use water to dissolve E464. It's going to be slow but it can be catalyzed with HCl. You cannot magically teleport the oxycodone out of the polymer, you have to dissolve E464 first. Trying other solvents is a waste of time according to me.

Once This is done, you will have in solution if I'm not mistaken:

- Oxycodone
- NaCl
- acetic acid
- succinic acid
- polymer

If taken orally it will be instant release but to obtain what you people call a ''sniffable powder'' one needs to isolate oxy from that cocktail of chemicals which cannot be done at home because you need tools...you need tools that cost 1000s of dollars. What people here want is a magic method to obtain pure oxy by mixing Wall Mart 4.99$/L solvents together ...not going to happen.
 
Imagine you have a nice glass of red wine that you want to drink. Unfortunately, a chunk of shit fell in it. So people are asking what solvents they can buy from Wall Mart that can separate the red wine from its shit content. Well....might as well throw it down the toilet and make the wine yourself.

It's not doable, I worked in the lab with stuff like that. Once you mix them together, the oxy is garbage from your point of view. I would go as far as saying it is easier to make the oxy yourself than trying to isolate it from that cocktail.


Everyone tries to come up with a solvent that destroys the polymer...wtf is the point of that, you'll end up with a powder containing 100 chemicals that irritates skin upon contact...

I think the solution is in crushing it in an extremely fine powder (use a tool...10 000rpm blades), add calcium sulfate powder, mix well to keep the powder dry at all time (keep away from air humidity) and do your extraction with a non protic solvent that does NOT interact with the polymer at all (so the polymer stays solid, that's the key) and dissolves the oxy, even slightly.

There will be a loss...yes but at least you end up with something ''sniffable'' -_______-
 
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Actually personally I'm not entirely concerned with obtaining 100% pure oxycodone, just something similarly as "pure" as the old forumula, just want to get the new crap out... I have yet to get an OP and try this but thanks cvalero and andrewv looking promising...is this not the solution?
 
So does the wax coating have any purpose? if i am going to nibble on the pill, do i need to scrape the coating off, or does it matter?

its time consuming and if there is no difference, id just cut into small pieces and nibble.
 
Ksa says it's not doable people (something about a turd in a punch bowl I think). Might as well close down the thread.

Oh, u think we should try to extract the oxy hcl with a solvent? It would be nice if purdue would have developed a 63 page PowerPoint presentation on the subject. Oh wait, they did!!

How very novel of you!
 
Did you guys ignore what I just read FROM Purdue?

The solvent experiments were tests in order to RAPIDLYT release oxycodone. Naturally, 100% of the oxycodone will be released in any reasonable solvent within 14-18hours! Even WATER, said one of the purdue people! JUst crush it and leave it in water for a couple days and you will have oxycodone released in water. It is a 12 hour medicine, so in 12 hours EVERYTHING is to be released!
 
Lets say I had just run into some Glacial Acetic Acid, what should I try first (what would you try, Andrew, Cvalero, anyone?) What are some of the best things to try?
1.) Place it whole, or in large pieces in the AA for 12 hours, then filter/evap?
-The reason I was thinking it may be better not to shred the pill, is might the matrix expand in the acid to allow the drug molecule's to escape into solution, as it is designed to do in the stomach?
2.) Powder it finely as possible, then soak/dissolve in AA, then filter, and evap?
3.) Are the Polymers and binders and gellers also soluble in AA, is this a waste of time and AA? Should the AA be put to better use? Please no negative defeatist responses. Help me to do something constructive here. Thanks.
 
Glacial acetic acid is a very interesting option. It is a polar protic solvent, same as water, so
it falls into the solvent category I would try first(polar aprotic being the second). But acetic acid is known more for dissolving inorganic salts. Also, glacial acetic acid is highly
corrosive and somewhat dangerous. It boils at 220f or thereabouts so it wouldn't evaporate at room temp. Also, the glacial type is hygroscopic, meaning it absorbs water. All these variable make it very difficult to predict how it would work. Also, dielectric constant of 6.2 (relatively static) so
it is hard to even predict what it would dissolve. Long story short,
I don't know, but I would be interested in finding out.

U would definitely want to grate it also. There is no situation where bigger pieces would work better. The reason for using glacial acetic is the lack of water, so the polymer should not gel.

One more thing. I think a straight water extraction as jaystyle suggested would be a good experiment. For one thing u will not risk losing any meds. How I would do
it is add 1 part water above 90C, stir, then add two parts cool water. This should completely dissolve the hypromellose (it will be gelled, which is to be expected). Then just let sit at room temp for 12-18 hours. The gel should completely hydrolyze and release all the meds. What I don't know is if the gel will remain viscous or not. But when u consume the liquid after, regardless of the properties, u should be getting 100% immediately released.
 
i didnt read the thread the whole way thru, but i have been googling it and a friend emailed me with his technique that he says works. swim has 30 of the new 80s that they got on clearnace lol. heres my questions. have anyone found a way to beat them? and if so what way? topix has a thread a guy says works. i dont want dude to was their money. so heres the email i got:

all they do is cut the OP in pieces with a blade and microwave it for several minutes (depending upon the Microwave) until it becomes brownish, and they do indeed become immediate release.

The important thing to highlight is that the Polyethyleneoxyde (PEO) melts at 160 degrees Fahrenheit, and the Oxycodone at 527 degrees Fahrenheit. If the PEO is kept to substained temperatures above of 200 degrees Fahrenheit for enough time (30minutes) the OP tablet or pieces turn brown indicating the PEO is broken down so releasing the oxycodone immediately.

360F for 30 Minutes turns it brown and immediate release.
450F for 5 Minutes turns it brown an immediate release.


its me back..

can someone varify this? im new at beating these new ones they just came around.
 
jaystyle said:
PS--- I bought an OP to fuck with today. I tried sucking on it like a hard candy and it worked pretty damn well. I let it sit under my tongue while I watched a movie, and sucked on it. I ended up nodding off to sleep and woke up with it under my tongue.

It has become a piece of jelly that is losing its bitterness. Its like a piece of candy that has lost its sweetness and now is just a shell of a pill. I realize my mouth has been successfuly extracting the oxycodone. Pretty cool-- got me pretty damn doped up!

It takes like an hour or two to fully absorb it all lol but you can just kinda go abotu yoru day with this bitter thing in your mouth, slowly doping up into bliss lol

Anyone else report on the "Succubus Technique"?
Click to expand...

this just got my interest as i wanted to give this a try and asked about using MsContins this way when i was prescribed them.

i'm now on OxyContin. I'm in Australia so Mundipharma is the sole distrubtor and is the easily abuseable OC.

more anecdotal reports of the new OP the "succuable" way would be interesting to hear:) chemical and fucking around free apart from having the pill in your mouth for a longer while than the usual buccal way.
 
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