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best antidepressant for MDMA induced depression

MeDieViL said:
Hypericum wich makes 5HT1A and 5HT2A more sensitive.
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Just what I was going to say. Unlike other anti-depressants st johns wort actually up-regulates serotonin receptors which is what MDMA neurotoxicity damages (among other things I'm sure). There is a thread on another forum about this for the purpose of 'regaining the magic'.
 
chaos_destroy said:
Just what I was going to say. Unlike other anti-depressants st johns wort actually up-regulates serotonin receptors which is what MDMA neurotoxicity damages (among other things I'm sure). There is a thread on another forum about this for the purpose of 'regaining the magic'.
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It's also a dopamine, GABA, serotonin, norepinephrine, and glutamate reuptake inhibitor, as well as an NMDA antagonist so I guess the glutamate reuptake inhibition doesn't do much.

It's also a powerful inhibitor of dopamine beta hydroxylase, which results in further increased dopamine and decreased norepinephrine.

It also has strong anti-oxidant properties, and even antibiotic effects against some bacteria (MRSA!)

SJW is a fucking godsend. You have to get the right brand though!

Also, to whoever mentioned theanine, yeah that stuff works pretty well too. Brand is also important, suntheanine ftw.
 
chaos_destroy said:
Just what I was going to say. Unlike other anti-depressants st johns wort actually up-regulates serotonin receptors which is what MDMA neurotoxicity damages (among other things I'm sure). There is a thread on another forum about this for the purpose of 'regaining the magic'.
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Yeah i've read that thread and all the succesfull reports.
 
Sweet P said:
Citalopram (an SSRI) works pretty well for me. I'm on 40mg a day, but that gets raised to 80mg when I'm having a rough time. I think it's just a matter of finding the right medication for you. Don't give up! And neurotoxicity from heavy ecstasy use isn't permanent - you're brain will eventually start to repair itself, if you give it a chance. :)
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CITALOPRAM upto 80mg is fine but cut down E use as much as possible, I know it's hard , I'm a psych doc and had fallen prey to Special K (Ketamine) use , it was hard and I still sometimes use. Since E cause the damage try other euphoriants like Lyrica, Liorseal, Benzo's, tramadol ,Admanta with Mirapex and so on.None of these cause brain damage :D
 
bben said:
Having destroyed my serotonin system through mdma use, are there any options besides suicide?

having run through all the antidepresants on the market and mood stabilizers there doesnt seem much left. They dont do shit for ecstasy induced depression.

Is opiates and benzos the only option here or is there some novel agent that is used i just dont know about.
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YEP THERE ARE WAYS TO RESTORE SEROTONIN BACK TO NORMAL , I'M A NEUROPSYCHIATRIST. USE EITHER /ANY ONE OF THE WAYS

1) A MAOI PHENELZINE + 5HTP SUPPLEMENT
2) BETTER USE THE STRONGEST SSRI - LEXAPRO 20MG OR (CLOIMPRAMINE WHICH IS TO BE BOOSTED BY BLOCKING METABOLISM BY 50mg FLUVOXAMINE)
USE METHOD 2 PREFERABLY

IF NEITHER WORKS U'LL NEED METHOD 3 IN WHICH U'R DEPRESSION MAY SLIGHTLY INCREASE
3)IN 2-3 DOSES TAKE 60-90 MG BUSPIRONE. THIS WILL SLOW DOWN SEROTENERGIC TRANSMISSION GIVING TIME FOR VESCICLES TO GET FILLED WITH SEROTONIN.FROM DAY 4 START THE METHOD 2 SSRI AND CONTINUE BUSPIRONE FOR 21 DAYS THEN TAPER OFF. CONTINUE SSRI FOR 3-6 MONTHS OR INDEFINITELY IF U ARE TO USE E AGAIN
LITHIUM CAN BE ADDED TO METHOD 1,2,3 BUT I DON LIKE IT ,U'LLNOT FEEL AN E HIGH ON LITHIUM.
 
bben said:
Having destroyed my serotonin system through mdma use, are there any options besides suicide?

having run through all the antidepresants on the market and mood stabilizers there doesnt seem much left. They dont do shit for ecstasy induced depression.

Is opiates and benzos the only option here or is there some novel agent that is used i just dont know about.
Click to expand...


YEP THERE ARE WAYS TO RESTORE SEROTONIN BACK TO NORMAL , I'M A NEUROPSYCHIATRIST. USE EITHER /ANY ONE OF THE WAYS

1) A MAOI PHENELZINE + 5HTP SUPPLEMENT
2) BETTER USE THE STRONGEST SSRI - LEXAPRO 20MG OR (CLOIMPRAMINE WHICH IS TO BE BOOSTED BY BLOCKING METABOLISM BY 50mg FLUVOXAMINE)
USE METHOD 2 PREFERABLY

IF NEITHER WORKS U'LL NEED METHOD 3 IN WHICH U'R DEPRESSION MAY SLIGHTLY INCREASE
3)IN 2-3 DOSES TAKE 60-90 MG BUSPIRONE. THIS WILL SLOW DOWN SEROTENERGIC TRANSMISSION GIVING TIME FOR VESCICLES TO GET FILLED WITH SEROTONIN.FROM DAY 4 START THE METHOD 2 SSRI AND CONTINUE BUSPIRONE FOR 21 DAYS THEN TAPER OFF. CONTINUE SSRI FOR 3-6 MONTHS OR INDEFINITELY IF U ARE TO USE E AGAIN
LITHIUM CAN BE ADDED TO METHOD 1,2,3 BUT I DON LIKE IT ,U'LLNOT FEEL AN E HIGH ON LITHIUM.
 
bben said:
Having destroyed my serotonin system through mdma use, are there any options besides suicide?

having run through all the antidepresants on the market and mood stabilizers there doesnt seem much left. They dont do shit for ecstasy induced depression.

Is opiates and benzos the only option here or is there some novel agent that is used i just dont know about.
Click to expand...

YEP THERE ARE WAYS TO RESTORE SEROTONIN BACK TO NORMAL , I'M A NEUROPSYCHIATRIST. USE EITHER /ANY ONE OF THE WAYS

1) A MAOI PHENELZINE + 5HTP SUPPLEMENT
2) BETTER USE THE STRONGEST SSRI - LEXAPRO 20MG OR (CLOIMPRAMINE WHICH IS TO BE BOOSTED BY BLOCKING METABOLISM BY 50mg FLUVOXAMINE)
USE METHOD 2 PREFERABLY

IF NEITHER WORKS U'LL NEED METHOD 3 IN WHICH U'R DEPRESSION MAY SLIGHTLY INCREASE
3)IN 2-3 DOSES TAKE 60-90 MG BUSPIRONE. THIS WILL SLOW DOWN SEROTENERGIC TRANSMISSION GIVING TIME FOR VESCICLES TO GET FILLED WITH SEROTONIN.FROM DAY 4 START THE METHOD 2 SSRI AND CONTINUE BUSPIRONE FOR 21 DAYS THEN TAPER OFF. CONTINUE SSRI FOR 3-6 MONTHS OR INDEFINITELY IF U ARE TO USE E AGAIN
LITHIUM CAN BE ADDED TO METHOD 1,2,3 BUT I DON LIKE IT ,U'LLNOT FEEL AN E HIGH ON LITHIUM.
 
nabollocks said:
^agreed. Tramadol or effexor would be a good choice. Be careful when discontinuing either of these drugs. Taper taper taper.
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Basically using a strong SRI and weak NRI that's what these drugs are at the given doses. u can try lexapro 10mg with remeron 15 that'll work even better I think as a p.doc, continue as long as taking ecx .don't take lithium as some say else u won't have the high- I'm experienced
 
Tramadol is probably great for this purpose, beware of addiction though.

While not too great for recreation purposes I found it to give an actual feeling of wellness when having a fever. A true malaise reliever. To me this is distinct from regular opioids (fentanyl, morphine, oxycodone) that sedate you with euphoria and bliss but don't take the actual malaise away.

I also had a great time mixing it with coke.. Turns out that is REALLY irresponisble though and might make you die like an ol dirty bastard.
 
Can i buy TRAMADOL online? (or is it illegal e.g. in the same category as heroin.)

(im fully aware of what tramadol is, its effects, etc. im asking about its legality and if i can buy it online legally, like with legal highs)
 
nuke said:
I've found that for severe MDMA/methamphetamine abuse SSRIs are contraindicated -- the users get very jittery and anxious and it doesn't go away from some reason. Try mirtazapine.
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No, SSRIs like Paxil / Prozac prevent the nerotoxicity of MDMA, so they should be on it and for the depression Lexapro10,Paxil, Buspirone is good
 
AfterGlow said:
mirtazapine worked well for me.
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Yes mirtazapine firstly blocks alpha -2 receptors releasing NE. NE and DA are coreleased in some brain areas. and blocking 5HT2 and 5HT3 receptors serotonin (5HT) transmission thru 5HT1 receptors causes an antidep effect. Mirtazapine isactually is now considered a stronger AD at high doses these days.
 
pofacedhoe said:
tramadol is far better than effexor for the record and was easy to come off which shocked me as it was less harsh than citalopram, effexor is noted for its brutal withdrawl effects.

i was taking 150mg of tramadol every morning for about a year

i feel much better than after citalopram- its the opiate effect that is the greatest antidepressant and after it wears off the chilled out thinking remains
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try lexapro 10 (escitatolipram) its even way better:D:D
 
Brian.Badonde said:
Since when is tramadol prescribed for depression?
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It's probably not prescribed for depression, but I can see how it could be effective.

As for the best anti-depressant thing, you could maybe try not taking it so often that you need a whole fuckload of other drugs to combat the depression, and just deal with it as one of the consequences of taking MDMA. I don't think neurotoxicity is an issue when used sparingly.
 
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