Jakeperson
Bluelighter
Yeah after a few years of abusing weed, it made it so much worse for me.
-
N&PD Moderators: Skorpio
best antidepressant for MDMA induced depression
- Thread starter Deleted member 137730
- Start date
negrogesic
Bluelight Crew
I would have to say, nothing. Eat well, and do consistent exercise. Let your body fend for itself before you conclude that anti-depressants are needed.
Mirtazapine is admitted not a "great" anti-depressant, but in order to work it must be taken with great consistency, and the effect is subtle and builds over time. I take it for its 5-HT3a antagonism, to stimulate my appetite. I am not depressed, but I consider it to be a far less toxic and safer alternative to SSRI's, some TCA's.
Before approaching something as serious as nardil, I would take a few months off and, as I said, eat and exercise. Our bodies are remarkably resilient.........
pofacedhoe
Bluelight Crew
well i smoked a lot of weed and i never got to the level of having no emotions whatsoever that i got from citalopram (with weed i still had anxiety and a grasp of what others might be feeling). i'm talking about robbing people (loads of alcohol where i worked) and not caring- something i would not have done before, also i ended up with a very bad heavy drinking pattern as when i was pissed was the only time i felt anything. drinking on citalopram in my experience was wayyyy more euphoric than drinking on its own is-this put me off it for lifeJakeperson
Bluelighter
Yeah Mirtaz is great for my appetite, I've never been a big eater so it's good to put some weight on.
I have only used MDMA once in the last 2 years now, still hanging around. That's what you get for thrashing your brain too young.
I exercise every day now but sleep is my biggest problem, I don't think thats related to the depression though.Deleted member 137730
Greenlighter
- Joined
- Sep 21, 2009
- Messages
- 583
Yes mdma induced depression either goes away in a few weeks or months or it tends to be semi-permanent and you adjust to the new person you are. Just be glad it didnt trigger anything like it did for me and alot of my boys (schizophrenia).it takes time to find the right ssri/snri that works for u, ive had to try 6-7 of them before i found the one that worked for me, but when i did, the dark clouds cleared and it reeally saved my life. about the mdma matter, id speak to a professional and remember, u need to be 100% honest about everything, otherwise they cant help ubest antidepressant: cocaine. best pharmaceutical antidepressant thats actually prescribed for depression: dextroamphetamine.
FULLY AGREE with this comment
negrogesic
Bluelight Crew
Cocaine is certainly power and fast acting anti-depressant. Its inherent toxicity, whether acute or as a function of time, makes it NOT the best anti-depressant. And d-amphetamine can exacerbate depression in certain individuals, especially those will chronic major depression.
Please do not propagate bullshit.....at least not in this forum. If you don't know what you are talking about........don't comment.
And in regards to tramadol, keep in mind the drug interactions; i've seen a number of deaths occur from the co-prescription of large doses of tramadol and other serotonergic agents. Death by hypertensive crisis is a painful way to die.......
Mirtazapine is one of the VERY few anti-depressants I would prescribe in concert with tramadol (due to its unique pharmacology, strong 5-HT antagonism). Antagonism of 5-HT3a is partially why it is a great anti-emetic/appetite stimulant. Its not the best anti-depressant, but in terms of toxicity, it is very favorable.......
Mr. Squiggle!
Bluelighter
- Joined
- Aug 31, 2010
- Messages
- 354
The most potent SSRI is the key here. Either Lexapro or Sertraline or better yet, Tyrosine. Google tyrosine bben. It's the key precursor in people's brains to cross the BBB and umm, make people normal again.
No OPIATES and BENZOS AREN'T THE ANSWER!
StaySedated
Bluelighter
selegiline, Depakote, and weed.
poopstation
Bluelighter
- Joined
- Oct 13, 2009
- Messages
- 375
personally i found opiates to be an incredible antidepressant for mdma-induced depression/anxiety. i used hydrocodone and oxycodone/acetaminophen pills. needless to say coming off them will be difficult but it makes me go from feeling like crap to feeling like a million bucks for a few hours then i have to dose more. so i dose low and dose every couple hours.
f**k tramadol, the withdrawals from tramadol are going to be far worse than regular opiates. not to mention tramadol's high sucks. it just makes me feel weird as hell and it screws with your 5ht receptors even more. regular opiates won't touch your 5ht receptors all that much so your serotonin is being replenish while you're slowly getting addicting to having endorphins readily available.
benzos help me considerably, not as much as opiates cuz opiates make me very happy but benzos calm the excessive anxiety from mdma overuse.
another option is to just take 5htp, fish oil, vitamins, exercise till you're exhausted and be sure to eat right. it's more difficult this way but it does work but this is a lifestyle change you'd benefit from and no withdrawals or dependencies. this is the much healthier option
Seriously? Cocaine is definitely not "inherently toxic", not even to the heart. Ok, you got me, smoking crack and shooting coke all day will fuck you up. If you take enough of anything its a poison, but small amounts of cocaine are perfectly safe, its been used by South Americans since before Jesus; I can give you a world of evidence on its safety in moderation bud. More so, cocaine is being touted by some as having neuro-protective properties, much unlike amphetamines.
Anythign can exacerbate depression. Are you not stating the obvious? But then you go on to say "especially those (im assuming 'with' not 'will') chronic major depression". Please be a little more vague.
Are you a health professional? If not, then dont say "I would prescribe". You have no to little idea of what med school teaches you...and you tell me not to write bullshit. Them you go recommending a drug with opiate action for depression? Yea, thats real smart bud. While I have no doubt that tramadol 'works' overall for depression, its only recently been put to wide use and so effects on the brain and body are inconclusive..unlike small amounts of cocaine. The idea of professional psychiatry is to rehabilitate , not mask ones feelings and create addiction... this is fact.
I merely wanted to add my honest opinion given the numerous studies that Ive read. Interestingly, I dont advocate using any drugs nor can I sincerely bring myself to enlist in illegal activity. Good luck finding your niche OP
negrogesic
Bluelight Crew
South Americans haven't been smoking highly pure cocaine base or using the salt intravenously for a few thousand years.
Cocaine (the extract) can cause ACUTE toxicity (cardiac arrest, allergic reaction etc) which can be fatal.
Chronic abuse of moderate-high amounts produces a unique movement disorder that you generally only find in people who have been abusing quite a bit of cocaine; particularly the base. I have only seen this with people who have been abusing cocaine heavily and consistently for 10+ years (this DOES NOT mean damage cannot occur prior to 10 years of abuse, this is simply from my personal observations). I have seen overdose victims, and I have seen overdose fatalities; i have seen their toxicology reports and while there are often other drugs involved, some show SOLEY the presence of cocaine-benzoylecgonine-alkylated esters, and many of the "polydrug" overdose victims show only the presence of cocaine combined with alcohol various degrees of toxicity). I have also seen acute cocaine overdose victims survive, only to be left in a vegetative or low-functioning neuropsychiatric state. I would rather die than survive that sort of overdose.
Do not post misinformation in this forum. In terms of the long-term toxicity, you generally see lowered transport density; the one most studied is the DAT, but the damaged is not limited to that transporter.
Given you are not acute allergic to cocaine, it is unlikely to cause significant or measurable damage with sporadic or limited use. Unfortunately, limited use is a word not know to those who become dependent on the drug (especially the base).......
http://archives.drugabuse.gov/pdf/monographs/Monograph163/Monograph163.pdf
pofacedhoe
Bluelight Crew
being a drinker of coca tea even i notice that regular use of it in any decent amount can result in chest pains to go along with the euphoria, its clearly bad for your heart. my intuition from doing years of drugs tells me that.
stimulants dont necessarily made depression better, especially if it has a psychotic edge
ho-chi-min, you are clearly a stim fiend but not everybody is.
tramadol if used in small amounts once a day was an amazing antidepressant effect. big difference in coming off it after that regimen and one of taking ever increasing amounts constantly for years.
i found coming off a once daily dose of 150mg tramadol less painfull than coming off a 10mg citalopram regimen. it was unpleasant and left me feeling exhausted but i switched to drinking green tea and within about 2-3 months i was feeling normal and havent really had any depression or mania since.
negrogesic
Bluelight Crew
Can you elaborate on the symptomatology of your "depression" (MDMA induced chronic or treatment resistant clinical depression - not a precipitation of an underlying disorder -is rather rare but can occur). For example; is your depression with or without psychosis, delirium, lethargy, "pain", anorexia, movement disorders/apparent neuropsychiatric features, or other symptoms that would fall under DD-NOS (not otherwise specified, somatic etc).......?
Have you had imaging done to see if you have measurable "destroyed your serotonin system", or have you experienced hypertensive crisis from acute toxicology or drug interaction when using MDMA?
Such a crisis generally calls for emergency life-saving measures; a hypertensive crisis is no joke and I have witnessed a few deaths from the syndrome; none from MDMA (my experience is limited;
I have yet to personally come across a case pertaining to MDMA specifically).
The cases that I witnessed were generally serious drug interactions like high dose tramadol with a high dose SSRIs/MAOIs (i've seen tramadol related hypertensive crisis more than once; but toxicology showed high doses, now that darvocet is banned, physicians are turning to tramadol as "weak opioid", not understanding that it can tragically interact with anti-depressants, aside from mirtazapine).
I must again say to continue with the mirtazapine, this drug takes quite a while to "work" and it lacks the toxicity of SSRI's etc.......
What was the rough dose/duration of the MDMA use?
negrogesic
Bluelight Crew
I wouldn't know, I've never taken it. The closest drug i've taken "relative to the structure" of the 2-AIs would be some of the oxazoline stimulants, like aminorex, 4-MAR, and pemoline. There are from what I recall more toxic compounds (pemoline should never have been banned in the US, the cases of severe hepatotoxicity were not sufficient "statistically significant" to warrant a ban). The black-box would have been enough.....
In the end, unless truly needed, the truly best anti-depressants are exercise, nutrition, hobbies (composing music for me) etc. Obviously, there are cases where it is warranted. But there are even more cases where they are not. Furthermore, an alarming amount of GPs or psychiatrists prescribe these compounds without knowing much more than the information given by the drug rep, etc.........
GBM
Bluelighter
Take it from someone who has been on Effexor and Paxil, DONT TAKE THESE. ITs not worth it cuz its gonna be a HUGE pain in the ass to get off them because of potentially fatal withdrawl symptoms. Also with the Paxil, when it started to wear off (at around 8-9pm) I would get the WORST suicidal thoughts ever.
