Xorkoth
Bluelight Crew
Albert Hofmann, who you probably know as the discoverer of LSD's psychedelic effects, also invented hydergine. He claims to have taken it daily to the end of his life. He died at 102, very healthy until he died.
Oh awesome. Would you think my chances of getting a script for it for my migraines would be good though? It'd be a lot cheaper to get it that way with my Rx insurance, assuming it's available in generic form.Yeah, but it's not controlled either if I recall correctly, which means you can order it from overseas and possess it legally.
It's actually a vasodilator.Does hydergine have vasoconstrictive effects? I'd guess it likely does if it's an ergot derivative. I don't see how this could be a helpful effect for nootropism.
GABA blockers
The GABAA α5 receptor site has recently displayed memory improvements when inverse agonized.
* α5IA - α5 inverse agonist
* Suritozole - α5 partial inverse agonist
[edit] Glutamate activators
The AMPA transmitter and the AMPA receptors are currently being researched, and there are signs that significant memory improvement and possible alertness enhancement may occur when agonized. The drug class for AMPA system modulation is called Ampakines. Although there are many Ampakines currently in-research, those mentioned here are significantly notable, and/or show reasonable signs of coming to market.
Some racetams have shown this activity
* CX-717 - Going through FDA approval for memory-impairing illnesses
* IDRA-21 - believed to improve memory by significantly enhancing long-term potentiation but used only in animals - incredibly potent
* LY-503,430 - Being developed for Parkinson's but showing increase in BDNF, specifically in areas of memory and higher cognitive skills
[edit] cAMP
Cyclic adenosine monophosphate is a secondary messenger that, if increased, has shown memory improvements. One common method is by decreasing the activity of phosphodiesterase-4, an enzyme that breaks down cAMP. Typical effects include wakefulness and memory enhancement.
* Propentofylline - nonselective phosphodiesterase inhibitor with some neuroenhancement
* Rolipram - PDE4 inhibitor, shows alertness enhancement, long term memory improvement and neuroprotection
* Mesembrine - PDE4-inhibitor with possible serotonergic activity
Can anyone add any information or experience with any of these?
Guys, there are rumors spreaded by vendors that the FDA is about to ban piracetam and everyone should stock up immediately.
I've read about multiple people saying this is most likely a scam, but of course there are also those who take it quite serious.
Pretty much the same thing seems to have happened in the Netherlands, there were rumors that GBL would be banned by january 1st but it still has not happened or anything. Of course, politics are a mess so it might just be put on hold for a while longer.
What do you think and does anyone have a verifiable source about this info?
I've been taking Hydergine daily for a month now (3.5mg at noon, rectally) and, wow, I am very very impressed!
This stuff enhances Ketamine's antidepressant effects. It also enhances Ketamine's linguistic-enhancement effects at low doses, and allows for intensely vivid re-experiencing of past-events with entheogenic K trips.
If I could get this stuff cheaply, I'd be taking it daily.