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The Big & Dandy Nootropics Thread

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Albert Hofmann, who you probably know as the discoverer of LSD's psychedelic effects, also invented hydergine. He claims to have taken it daily to the end of his life. He died at 102, very healthy until he died.
 
I am on a weekday regimen of the following nootropics/supplements:

Morning:
Piracetam 800mg
Centrophenoxine 250mg
Hydergine 4.5mg
Vinpocetine 5mg
Fish Oil 2000 mg
Men's Multivitamin

Evening:
Alpha Lipoic Acid 200mg
Acetyl L-Carnitine 400mg
Melatonin 3mg
CoQ10 200mg
B-Complex w/ Folic Acid & Vitamin C

I am thinking adding the following each morning to my existing regimen above:

Pyritinol 100mg
Huperzine A 200mcg

Additionally I have heard good things about Sulbutiamine and was wondering if anyone had any thoughts about adding it or the two above to my existing regimen.

Any thoughts on the stack and potential additions is greatly appreciated.

Note I am a regular cannabis user, occasional cocaine user and occasional phenethylamine and tryptamine user.
 
Yeah, but it's not controlled either if I recall correctly, which means you can order it from overseas and possess it legally.
 
Hydergine felt like poison to me.

7.5mg, was it? Split in half, under the tongue I think. Took in in the morning. My chest starting feeling heavy, heart weird, sweating. Had to go lie down in work. This acute phase of shittiness lastest only a few hours but yeah if anything ever felt like a cardiotoxin it was that.
 
Does hydergine have vasoconstrictive effects? I'd guess it likely does if it's an ergot derivative. I don't see how this could be a helpful effect for nootropism.

Did anyone else find DMAE made them edgy and aggressive? I love most choline enhancers; lecithin has gotten me through medical school and been a big help with muscle contractility at the gym. But DMAE I just didn't enjoy. Maybe it was the fact that it masked sleepiness, without eliminating the need for sleep, thus resulting in irritability, I dunno.
 
So for the past few months I've been feeling unmotivated and lacking energy. As such, I was wondering if you guys have any recommendations; I know diet and exercise are big factors and I've been eating better and working out regularly... but it's not quite how I used to feel.

This malaise came on, though, when I wasn't taking much -- the only thing I used during that period was DXM maybe once or twice over three months and that doesn't seem like it'd be enough to still bother me four months later.
 
Found some interesting Nootropics on wiki the other day which i have never seen discussed.

GABA blockers

The GABAA α5 receptor site has recently displayed memory improvements when inverse agonized.

* α5IA - α5 inverse agonist
* Suritozole - α5 partial inverse agonist

[edit] Glutamate activators

The AMPA transmitter and the AMPA receptors are currently being researched, and there are signs that significant memory improvement and possible alertness enhancement may occur when agonized. The drug class for AMPA system modulation is called Ampakines. Although there are many Ampakines currently in-research, those mentioned here are significantly notable, and/or show reasonable signs of coming to market.

Some racetams have shown this activity

* CX-717 - Going through FDA approval for memory-impairing illnesses
* IDRA-21 - believed to improve memory by significantly enhancing long-term potentiation but used only in animals - incredibly potent
* LY-503,430 - Being developed for Parkinson's but showing increase in BDNF, specifically in areas of memory and higher cognitive skills

[edit] cAMP

Cyclic adenosine monophosphate is a secondary messenger that, if increased, has shown memory improvements. One common method is by decreasing the activity of phosphodiesterase-4, an enzyme that breaks down cAMP. Typical effects include wakefulness and memory enhancement.

* Propentofylline - nonselective phosphodiesterase inhibitor with some neuroenhancement
* Rolipram - PDE4 inhibitor, shows alertness enhancement, long term memory improvement and neuroprotection
* Mesembrine - PDE4-inhibitor with possible serotonergic activity

Can anyone add any information or experience with any of these?
 
I just started taking lecithin and would like to say that it tastes and smells like week-old garbage. Any suggestions for getting past this?

Can anyone add any information or experience with any of these?

They're a pretty new class of drugs, I don't think it's possible for consumers to order them yet. I'm excited about them and I'm also excited about histamine H3 antagonists.

I think we'd have the best chance of seeing these if we can get RC vendors to stock them.
 
Guys, there are rumors spreaded by vendors that the FDA is about to ban piracetam and everyone should stock up immediately.

I've read about multiple people saying this is most likely a scam, but of course there are also those who take it quite serious.

Pretty much the same thing seems to have happened in the Netherlands, there were rumors that GBL would be banned by january 1st but it still has not happened or anything. Of course, politics are a mess so it might just be put on hold for a while longer.

What do you think and does anyone have a verifiable source about this info?
 
Guys, there are rumors spreaded by vendors that the FDA is about to ban piracetam and everyone should stock up immediately.

I've read about multiple people saying this is most likely a scam, but of course there are also those who take it quite serious.

Pretty much the same thing seems to have happened in the Netherlands, there were rumors that GBL would be banned by january 1st but it still has not happened or anything. Of course, politics are a mess so it might just be put on hold for a while longer.

What do you think and does anyone have a verifiable source about this info?

The only "source" I have found is a quotation from an email sent by a supplement vendor. I have not found any official or reputable sources of the piracetam ban. You think there would be at least a few pieces of information on the subject. I am weary, but also slightly concerned as I could see the FDA pulling this kind of bs and I use piracetam everyday as a 'life enhancer', so I'm keeping a close watch. If anyone has any news please contribute, as long as it is backed up and not rumor that has spread around. I was ready to purchase 3 kilos but decided against to wait and see.

On another note,

I'm currently I'm taking 800mg to 1 gram of piracetam a day combined with 300 - 500mg of choline citrate. Are there any better sources of choline out there? I've heard of lecithin being a good source too, as well as DMAE (I think). I'm actually looking to add more ingredients to my regimen to create a perfect stack for myself. Hydergeine sounds interesting for sure. I'll have to do my research, but are there any notables one can throw out so I can begin to research for myself? There are quite a lot of supplements and various nootropics so it is kind of overwhelming to find out what is what. Also, would anyone recommend trying any of the other racetams if I am experiencing very positive results from piracetam alone?

I'm asking a lot, so I'll give back to the community and tell you about my experience with piracetam. Fortunately for myself, I stumbled upon this awesome powder about a year ago, never looking much into it but understanding that some people receive great benefits cognitively from piracetam, so eventually I ordered my own. Fast forwarding to the beginning of May, I received my piracetam and choline citrate. About 15 - 20min after ingestion of about 800mg to 1g of the stuff, I was subtly experiencing a heightened sense of awareness with increased intellectual capacity for thinking and perceiving the world, as well as a spike in creativity. I was shocked, but utterly happy to have been exposed to such a wonderful drug.

I've been a yerba mate drinker for about 3 months before this and when I combined piracetam + yerba mate, it was like the most perfect combination ever conceived. I couldn't believe the potentiation that piracetam induced. I was so surprised at how much more 'active' the small amount of caffeine in mate became, yet was never once too stimulating, jittery, or full of the side effects a cup of coffee produces, that I knew I would have to continue to experiment, and even turn to a healthier lifestyle. Deciding that growing my own organic veggies was the only option to affordably eat organic produce, I started work on a garden of my own that has since reaffirmed my faith that eating healthy vastly influences one's physical and mental being.

I can honestly say that piracetam has helped me on my path greatly in my school, social, and work life that without it, I don't think I'd be exactly the same person I am today. I'm not trying to portray piracetam as some god given gift to man that cures everything, but through its cognitive effects on my psyche has lead me to a much more fulfilling and healthy lifestyle. Of course it was I who had to choose the life I live, but piracetam helped me to fully render the capacity to do so. I owe so much to this drug that I couldn't possibly think of life without it. This is why the supposed scheduling of piracetam extremely worries me. I've been dosing since May 6, almost everyday with a few days of absence, sometimes twice a day, and everyday I have been drinking yerba mate. It has become part of my morning ritual and part of my life. I never notice any negative side effects which is why I would like to continue my experimentation with other nootropics in combination with a healthy diet and excercise, and I wish everyone would do the same because I now view life in a much more vibrant, energetic and fun way than ever before.

sorry for the ramblin, I just had to share my experience.

much love
 
I've been taking Hydergine daily for a month now (3.5mg at noon, rectally) and, wow, I am very very impressed!

This stuff enhances Ketamine's antidepressant effects. It also enhances Ketamine's linguistic-enhancement effects at low doses, and allows for intensely vivid re-experiencing of past-events with entheogenic K trips.

If I could get this stuff cheaply, I'd be taking it daily.
 
For choline I use choline citrate, with DMAE I have quite nasty experiences like feeling really toxic, there is no better explanation but it was just plain wrong and I stopped taking it. Lecithin is quite good as a choline source, alpha-GPC should be even somewhat better and I heard centrophenoxine is one of the best. It's not cheap though I think.
Anyway I derived this information from all sorts of sites here and there, it is not quoted fact.
 
I'm actually not a fan of centrophenoxine; it seems to make me wonky-headed and give me low level headache. All this is when combined with piracetam though; I've never done it on it's own.

I'm going to start taking lecithin daily just as something I take with my multi-vitamin and fish oil.

I've been taking Hydergine daily for a month now (3.5mg at noon, rectally) and, wow, I am very very impressed!

This stuff enhances Ketamine's antidepressant effects. It also enhances Ketamine's linguistic-enhancement effects at low doses, and allows for intensely vivid re-experiencing of past-events with entheogenic K trips.

If I could get this stuff cheaply, I'd be taking it daily.

Yeah, the price is a biotch. Are you still taking that "ketamine as an anti-depressant" regimen I've read about from you?
 
^ Yes I am! :). And the more I perfect it, the more miraculous its consistency works. I discovered so much from my last experiment (about 1 month ago - whose effects I'm still feeling today, without dosing at all for about 2 weeks - so much so in fact, that I simply stopped taking welbutrin (my Rxed antidepressant)) and feel a thousand times better than when I was on it.

If you're interested, you may want to check out the recent ADD forum thread on the subject where I posted my observations on the therapeutic process now that I had been working both with sealed vials as opposed to powder (thus with accurately measured doses) and a pretty strict dosing schedule with an average dose of about 12mg. But either way, I intend on rewriting my regimen thread here in PD because I truly believe that Ketamine, when used responsibly and with such infinitesimal doses, can bring (natural-feeling) joy into the lives of those in pain, and has absolutely no negative side-effects, be they cognitive, renal, or absominal (note that this ONLY refers to the small doses mentioned above - larger doses will still work, but will most definitely create all the classical K side-effects).
 
Go to IMMINST.ORG click on the "forums" tab.

LOTS of very sciencey dudes over there. Forums on Supplements and also Nootropics are endless sources of info and opinions... its THE place to go for nootropics advice. It would be awesome to see some of you all over there!

I don't like vinpocetine (neither do most folks at imminst). Something about it makes me feel wonky and wierd... headaches too. Some like it though I know.

I like centrophenoxine.

Sulbutiamine is AWESOME! (cheap bulk powder can easily be found from various sources). Take 800mg and it TOTALLY eliminates fatigue from lack of sleep or other reasons for several hours. Add a little stim of any category (even caffeine), and it can be VERY effective and helpful... great to have on-hand for work days after a sleepless night.

Piracetam can be good, though it makes me feel sleepy more often than not.

Be sure to get extra choline, via Choline Chloride, DMAE, cdp-choline ("Citicholine", probably peoples' favorite) when using any of the -racetams, as they can cause acetylcholine to be depleted in your brain.

I prefer (though others dislike... its very scattershot who likes what) ANIRACETAM much better... doses are smaller, and it feels alot brighter and more stimulating... I get an "in the fog" feeling from Piracetam but not Aniracetam.

There's an amino acid you can get from Source Naturals, "Pyroglutamic Acid" that gives me a VERY alert nootropic effect.

Also, the liquid DMAE-H3 from Twinlabs is VERY effective, better than dry DMAE. Though DMAE is kinda 50/50, some get great effects from it, some don't.

The Twinlab DMAE-H3 is a combo of DMAE with PABA that is almost the same as one of the earliest nootropics and anti-aging compounds, Gerovital.

According to a poster at IMMINST:

http://www.imminst.org/forum/topic/42364-dmae-thoughts/page__p__419856__fromsearch__1#entry419856
I think Gerovital breaks down into PABA and DEAE, not DMAE. As I understand it, they are related compounds but not the same. Twinlab came up with something new with DMAE-H3, probably because the research results seemed stronger with DMAE than procaine, but they wanted to capitalize on the Gerovital name.
 
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