Bupe Suboxone/Buprenorphine FAQ & Megathread v2; 2010

[mike_indy_317]

hedon you should go to a doctor and get a script your supply right now could run out and then you dont have any.

 

[Captain.Heroin]

yes apologies for multiple posts...new to the site and couldnt even find my old posts...my head is mush right now.....so please accept my sorries for the inconvienence

I'll close your extraneous thread so we can discuss this here.

is the secret to getting high off iv bupe lowlow doses? do u actually feel more from iving 1-2mg then 4-8?

I get a lot more out of < 1mg per shot than anything above. Everyone is different though, the only way is to find out for yourself. I suspect if you do IV it, a lower dose will be better.

hm.. i know nothing about that actually, very interesting...know anything else or where i can read that info...much apreciated

http://en.wikipedia.org/wiki/Norbuprenorphine

oh...and once u hit 3 mgs...does that mean a.7 dose wont get u high anymore...or can you do that all day long and catch a buzz? ie: i already have 12mgs in my system....will 1 mg get me off or do i just need to wait til tomorowo?

I would wait until tomorrow if you can.

 

[DkBlaze1]

Do you not know about how bupes metabolite norbupernorphine is a full agonist and how when you take low doses it leaves receptors open for norbupe to bind and get you high because bupe has a higher binding affinity to the receptors so if you take a higher dose the bupe will fill up ALL the receptors and leave no room for norbupe.......basically the lower your dose is, the more room you have for norbupe to bind and get you high/euphorical.

WOW thank u for that if this is correct which it most likly is it makes a huge amount of sence and thank u alot for that ...

 

[DkBlaze1]

buprenorphine is by far the most weird drug i can think of

 

[DkBlaze1]

and will you guys let me know what you know about how CYP3A4 inducers and inhibitors will act on the high from suboxone... llike would it cause the body to metabolize more of the bupe into nor bupe thus being able to take a higher dose of bupe knowing the bupe will be higher metabloized into nor bupe thus getting you higher.. ?

 

[f13nd]

I think from what I've read about bupe and metabolization is the inhibitor should cause bupe to metabolize slowly, and bupe blunts alot of norbupes effects so the norbupe works better. Im not sure if thats right tho

 

[stray cat]

i've been reading a lot on here lately about keeping the bupe doses low so that more of its metabolite (norbupe- apparently a full agonist) can get access to receptors. is it the general consensus now that this is what produces the high experienced by users at lower doses? i'm just curious- i'm pretty sure i had read most of the sub/bupe posts up until about a month or 2 ago, and i don't remember this theory really being so prevalent then. is this a fairly new development? (i know people always said less is more and that they felt more off lower doses, just not the part about the metabolite). are we pretty sure that's why most users get better effects at lower doses? i'm just wondering bc it's pretty much treated as fact now, and i don't remember hearing it so much before. it makes sense... just curious if that is definitely the deal or just the most popular theory now or what. thanks!

 

[DkBlaze1]

it makes totall sence even though its comepletly counter intuitive. I found that when researching things it was easyer to research TEMGESIC info because this is somthing were they are using the effects of nor bupe as the opiate and once the person hits the ceiling they are then unable to get effective pain relieff so instead of people searching about how to get high of suboxone which would be hidden i think its a better idea to find out info about effective pain relieif and such from TEMGESIC anyway I completly belive the Idea of the nor bupe being the thing that gets you hgih i know that in my clinic they were stressing me cuz for some reason in my piss the nor bup was high so that is clearly something that they know is the thing getting folks high. N e WAY i got my dose down to 2 mg today and im not sick or anything im just stressing cuz i got kinda nice for about an hour but now im not and i know i should just pass out but i have a feeling Im going to try another 1 mg shot to see where it gets me seeing as everyone seems to be in agreement that 3 mg (IV) is the ceiling of the effeects were lookingh for
http://www.medsafe.govt.nz/profs/datasheet/t/Temgesicinj.htm
///

 

[DkBlaze1]

AND I have one more ? for everyone whos sees this do you guys who are on bupe FInd that you have urinary retention because I sure do and it is only been since i started suboxone

 

[Georgie25]

yeah thats with any opiate

 

[DkBlaze1]

with suboxone its way more of a problem for me like ive cryed like a little girl after having to try to piss for an 2 hours after the first 30 mins i had to sit cuz i waas soo fucked up and then for the next hour and a half i was nodding in and out trying to piss this was when i was opiate nieive but i still have a real hard time pissing.

 

[Captain.Heroin]

is it the general consensus now that this is what produces the high experienced by users at lower doses?

Oh yes, I get splendid results with 26 mcg per IV injection. If you told me that I could get high one day on 0.026mg of buprenorphine, a long time ago when I didn't know all of this, I would have thought you were crazy. But now I know it to be the truth.

I don't think that low doses work for everyone though, and I think there are good reasons for this (i.e. long term full agonist opiate use, or an enzyme hyperactivity).

AND I have one more ? for everyone whos sees this do you guys who are on bupe FInd that you have urinary retention because I sure do and it is only been since i started suboxone

I don't remember when I was on a larger dose, but urinary retention is not a problem for me.

Buprenorphine tends to have unique side effects ranging from individual to individual. Some Bluelighters complain of sweating/hyperhydrosis, others complain of headache, some people get violently nauseous/vomit (<-- in the beginning this is what made me stop using it sublingually, vomiting up your medicine before its done dissolving is no fun), and yet others get too much stimulation from it. Some people get an allergic reaction from it which causes severe itching.

with suboxone its way more of a problem for me like ive cryed like a little girl after having to try to piss for an 2 hours after the first 30 mins i had to sit cuz i waas soo fucked up and then for the next hour and a half i was nodding in and out trying to piss this was when i was opiate nieive but i still have a real hard time pissing.

Have you tried a lower dose? Perhaps on a lower dose it would be easier to urinate.

Also, stimulants do an excellent job of getting your waste products evacuated, in case it's maddening and you need some help.

 

[DkBlaze1]

Oh yes, I get splendid results with 26 mcg per IV Buprenorphine tends to have unique side effects ranging from individual to individual. Some Bluelighters complain of sweating/hyperhydrosis, others complain of headache, some people get violently nauseous/vomit (<-- in the beginning this is what made me stop using it sublingually, vomiting up your medicine before its done dissolving is no fun), and yet others get too much stimulation from it. Some people get an allergic reaction from it which causes severe itching.

This sounds to me more like Naloxone hypersysitivity thats the same sorta shit that HAppened to me. Its weird because even though its not active i hear left and right about people having negitive effects from it. yet you can still shot subs. The thing that really gets my goat that they never tell you when you get on this shit is that your moods gonna b shit because along with being an opiate inhibitor it also inhibits your endorphens which is fucked for some company to add that naloxone bs when its pruly just for a the ablilty to target a market and own it while keepiung the patent. i heard the patent for subs got exstended for some reason anyway im not sure about that but all of what i said before im sure of naloxone is some crazy bad shit and if u have liver problems like me stay the fuck away from it subutex is bad enough for your liver as is

Have you tried a lower dose? Perhaps on a lower dose it would be easier to urinate.

and ya I lowered my dosse today bro and i felt nice with the first 2 mg dose for an hour nonthing to wirte home about but a defenite better feeling then the second time I did like 4 hours later at 1 mg felt good for an hour and a half still nothing amazing . but tommarow its gonna b two 1 mg doses for me and ill get back to yall about how it goes.. anyone with liver issues i tell you this get on subutex it will safe your life . its also so noticeable how the endrophines are inhibited by that gosh darn naltrexone fucking sick shit

 

[Captain.Heroin]

and ya I lowered my dosse today bro and i felt nice with the first 2 mg dose for an hour nonthing to wirte home about but a defenite better feeling then the second time I did like 4 hours later at 1 mg felt good for an hour and a half still nothing amazing . but tommarow its gonna b two 1 mg doses for me and ill get back to yall about how it goes.. anyone with liver issues i tell you this get on subutex it will safe your life . its also so noticeable how the endrophines are inhibited by that gosh darn naltrexone fucking sick shit

Honestly, when I used both Subutex and Suboxone, at the exact same dosage, I experienced no difference.

I tend to think that there's no difference between the two, except for rare people who have a naloxone sensitivity issue.

 

[DkBlaze1]

i agree completly except i def have that problem suboxone made me throw up. headache all day and the lack of happyness was real bad no highs and lows i was just blunted to all my emotionns and my liver didnt do so hot

 

[Captain.Heroin]

i agree completly except i def have that problem suboxone made me throw up. headache all day and the lack of happyness was real bad no highs and lows i was just blunted to all my emotionns and my liver didnt do so hot

I'm really sorry to hear that, the only problem I had with Suboxone was vomiting, and when I switched ROA's it went away. Since it lasted for months I suspect it had nothing to do with acute heroin withdrawal either.

You said Subutex doesn't have these problems for you?

 

[ChemicalSmiles]

CH I know you could answer this. I took 4 mgs of sub last night at 5 pm its 1 pm now the next day. How long until I can feel 40 mgs of oxy all the way... im not on sub maintainence I just had a half and wanted a little taste of a buzz.... now I got some real shit..... Should I just wait till tomorrow morning/night?

 

[hale]

methadone after suboxone?

don't see it anywhere in this thread. will add once i get a solid answer

 

[ChemicalSmiles]

I never bump but ive been clean for a while and I want to feel something!

 

[hale]

are you saying you never bump suboxone?

if so and you've been clean a while just break roughly 1.5-2mg off and bump it in small bumps.

you will feels good man