Yeah, if you snort (insufflate) 80+mg Oxycontin's and 10-40mg Opana's, Your gonna be FINE. unlike phenantherines (my fav class of opioid drugs)[ie morphine, oxycod/morph, hyrdrocod/morp, codeine, heroin etc] Methadone is a diphenylheptane. And well, there is incomplete cross tolerance, but you would get higher from the oxycodone or oxymorphone. Methadone does'nt really give opioid addicts a great buzz. Actually its more of a sweaty "glow" that diminishes after several week of prolonged useage. Also long as your not overly nauseous or itchy, and are breathing ok, then Buddy, your gonna be fine. Actually if you a physically dependent on opiates (like me) then your gonna be happy. You will be good (ie: not dope sick) for about 2 days!!!! that's always nice. But don't do (waste) your oxy or opana until at least 48-72hrs after the 60mg of the methadone you took. The opana and oxycontin will NOT properly work with the methadone. Its like wasting them, as the methadone wont let them near the Mu-2 receptors until they are done binding. Methadone and naltrexone/naloxone have the highest affinity for the mu receptors. GOOD luck, and enjoy the next 24hrs as you wont become dope-sick.