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How toxic is Mephedrone?

right these stories of vasoconstriction for days after the dose really concern me i always buy mine from the same guy and its strong has little smell and causes minimal vasoconstriction to the point where i had a 3g binge and still had nicely blood filled limbs combined with no chest discomfort and my heart rate remained at just above normal.

What i am asking is does anyone know whether these more severe side affects are caused by impurities or just individul difference becaus i have seen at least 30 different people on the stuff i get always fro the same guy and they all seem fine.

and honestly its not that its weak i am a regular user and it still merks me.
 
I think it's both: there surely has been a lot of poor quality meph going around after it gained that notoriety, but it's also a lot to do with personal biochemistry. The 3 times I used meph was always with the same person and he was taking just as much as me, but he got no aftereffects from it, no palpitations, nothing noticeable.
 
A few people on here must have bought really bad stuff or just mix it with too many other drugs/alcohol. I bought mine off a site that no longer exists like the rest 'topdogplantfood'

I never had any of the blue arms, blackouts etc that people are experiencing. I would generally take anything between 1/4 and 1/2 a gram in one night after alcohol. Then drink water afterwards.

I had some fantastic nights on it, the worst thing would be the dreams/nightmares for the following 5 days but I got this after MDMA too. One of the other things was that I had cold feet and hands, but this was probably down to also dancing for 6 hours, then walking home in winter in a tshirt and thin trainers. Also the standard stuff like chewing a lot

I think the key is moderation, I never took more than 1 gram in a night and when I did, didnt touch it for a month then 1/4 would do me a good 5 hours. The only reason its illegal is because of retards who went on 3 days binges of alcohol, cocaine, whatever else and methedrone. Methedrone was obviously found in the body and so it was blamed. - anyone remember the story of leah betts who had ecstacy then danced herself to death in hot club, drank bucket loads of water and collapsed, not the wisest thing to do if you have a weak heart and are unfit
 
Hammilton said:
Well, probably is a strong MAOI and DARI in one. There's no pharmacological data to support or deny this, but assuming it is, is a lot smarter than dying over it.
Click to expand...

Can someone tell me what MAO1 or DARI is? im confused lol
 
hunuh said:
monoamine oxidase inhibitor, dopamine re-uptake inhibitor
Click to expand...

And this is bad because the DARI prevents large amounts of dopamine from leaving the synapse so dopamine builds up, then usually monoamine oxidase would help in eliminating the excess dopamine but an MAOI inhibits MAO from doing this, creating a bad scenario...
 
to be pedantic, it likely acts mostly as a releaser than a reuptake inhibitor.
...
I just caught word that intermediate-level distributors are buying from China and selling the shit as "sunshine" on the streets, all over Oregon, but also as far as Phoenix. This shit will be scheduled soon, and good riddance (this marks the first time I've thought such about prohibition of a substance).

ebola
 
Been sampling Mephedrone last 4 weekends on a sat night, never used more than 1/4 Gram in a night and had no real nasty side effects, noticed seem to sweat a lot more and occasionally have a bad headache on monday especially after doing some hard graft. Have noticed random pins and needles for 3-4 days after each session. Normally had a few beers before the meph nothing too much just 4 or 5 beers, don't know why but my enjoyment of any stimulant seems much more enjoyable after a few beers.

I don't think this drug is that bad just people seem to lack any form of self control with it, not once have i been unable to stop when i notice the sun coming up lol, i do love the fact i can be buzzing one minute and fast asleep 30min after a bump.
 
Given the higher ignorance our drug users show compared to foreign ones, I'd say content.
 
Well here's some facts. I check for info on anything I'm planning to take and when I first heard about mephedrone (18 months or so ago before it was widespread) & it didn't look too bad... read up online & everyone in the know seemed to be having a beano with this stuff with minimal comedowms/side effects. So I ordered...street drugs had hit an all time low, so...

Now I know different. positive, there's the first few first hits, the 'honeymoon period' where it makes you feel wonderfull...one of the best hits I've ever had was on meph.

Then it suddenly changed..the binges started, the negatives magnified rapidly.

I know its chemical name & all that, but what difference does that make if you're mate suddenly collapses, eyes rolled up, face going this horrible purple colour etc (the full story of that is on a mega thread on OD. Anyway he survived but it was close (I'm not a medical person/expert) I just know it was.

For a while I thought it was an ambulance job, and I'm thinking what to tell the paramedic, ''Oh he's taken mephedrone, you know the stuff, methylmethcathinone''. The guy wouldn't have had a clue what I was talking about. And I was feeling bad because it was me that gave it him. Small dose, bout 150mg and he nearly died.

Its nasty stuff & hasn't done me any good at all. I wish I could turn back the clock, had those first 4 blissful doses, then sacked it off.

One strange but positive effect its had on me, its put me off cocaine
 
after a 13 month near daily use my heart constantly feels not quite right, sometimes cigarettes cause palpitations etc....

I had a stupid meph habit and boy now I’m feeling it.

The head zaps have stopped but I still wake up stinking of the stuff (this is a good 4 months after cessation) and although I had an awful dip of depression (resulting in suicide attempts and inpatient psychiatric treatment) my mood is far more stable and I don’t experience dips as often.

If someone was using 8-20 grams per binge and binging 3 times a week for 13 months, is there any supplements or substances that could be used to manage the long term effects or anything that could rid the body of it quicker?
 
Making no claim that mephedrone is safe, but 8-20 gram binges will cause major side affects with llots of things. Go on a binge with a half oz. of coke or meth and see how you feel afterword. To answer the question the drug has long since left your body.
 
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