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How toxic is Mephedrone?

MrM said:
Perhaps this is the result of a young kid having access to large amounts of a powerful drug for a year?

I have no doubt if a 13 year old kid spent a year taking dozens of grams of MDMA they might have similar problems.
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I think the vast majority of psychoactive substances would mess a developing brain up. i mean i saw psycho kids round where i grew up and that was the result of 'just' alcohol. plus i think regardless of age heavy frequent drug use does just mess you up, most people on this forum have probably see people 'turn into shadows of their former selves' (sorry for the cliche!!) cos of too many drugs.
 
Is it not also quite likely that emotionally unstable people are more likely to develop self-destructive patterns of substance abuse? I mean, it's not like "completely normal 12 year old boys" all start hammering mephedrone.
 
IsaacE16 said:
There's a boy I know who at the age of 12 was a completely normal 12 yearold boy a bit shy but normal, at the age of 13 he became seriously addicted to Mephedrone, buying grams in their dozens off the internet, now at the age of 14 he has come off mephedrone, but the damage is done, he has gone insane, don't ask me the ins and outs of it I'm not an expert, but this shy boy, has turned into a loud, twitchy, wreck who is always shouting and can be seen at the local music festival starting fights he always looses pouring beer over himself and passed out in a pool of his own vomit.
This was a definate result of the mephedrone as the change was to fast and to extreme to just happen over two years naturally
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So he cured his shyness? Damn, sounds promising, maybe I should try this "medication" also to cure my shyness.
 
deckmunki said:
I'd appreciate more details from you; how did you find out you have heart disease, what were te signs and symptoms, what's your medical history if any, age, weight, lifestyle, etc?

The more information you provide, the better the chances you could help someone else who might be in the same situation without realising it.

What treatment are you getting?
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5'11'', near perfect body mass index, a bit unfit though and a smoker. I'm approximately 30 years of age. Never any huge binges that led for more than twelve hours, no ridiculous doses at any one time, and a couple of breaks in between. It was considered quite pure, and looking at some with a microscope out of curiosity made me feel firm in that belief, although certainly not the most scientific method.

My lifestyle doesn't allow a huge amount of excercise due to the nature of my work, and doesn't leave me with much time to sleep (rarely more than three hours), and I mostly take substances for (mostly) medical reasons that are to do with GABA. I'd experimented

Symptoms started with extreme dizziness, feintng, extreme palpitations, pain in several areas of my heart (I forget which; my I'd forgotten what the doc said about that) a near heart attack which could have been lethal if there wasn't anyone about, extreme sweating even in extremely mild weather. The minor sympoms started getting much worse about five days after the last use of Meph, and just increased. After the first dose and funzies with it, the minor sympoms started, and grew each time.

The worst came from the last 'times of using', ie., after my last. It's hard to even call them binges. Probably no more than 400 mg on any one occasion?
No family history of heart disease, although alcoholism has been on both sides of my family. I go in and out of that. I've never had any other health problems, aside from the odd bout of pneuomonia.

I eat well, cook my own food, grow a lot of it myself. I've settled down a lot from experimenting when I was young with other drugs, and it Mephedrone was just... Well, you go to a party and don't say no. I just find most chems... Well, boring. I've tried a lot when I was young, and it's a case of 'been there, done that'.

Barrages of tests still going on, most I can't remember the name of. I was in 'perfect health but perhaps needing to get more excercise' in a checkup before trying it. I probably only took on occasion over a period of perhaps... Six weeks?

I'm on several medications since this, but right now am too damn tired and exhausted to get out of bed to check what they are right now.

I certainly wasn't allergic to this, but certainly did feel some of the symptoms building up over my use.

Oh, I've also had chronic insomnia, hence the reasons for being on GABAgenics. Only occasionally do I have 'fun' with those. Aside from that, I keep to my dose.

I'm ridiculously tired right now, so I hope this isn't too vague and incoherrant.
 
Oh, forgot to mention two electro cardioversions.

My heart was fine before. I think that I may stand alone in this, as most folk don't seem to have had such serious reactions. But there could very well be a certain amount of people that these things could happen to? Eh, who the fuck knows.

Shame the best research we can do with these RCs are human labrat reports PS.
 
we all sniffed glue at that age and apart from the asthma and constant herpes of the mouth im just fine for the experience:P

im not condoning taking glue but i have had some crazy trips on that shit

getting back on topic, meph is highley toxic imo, i have taken twice and both time i felt like death for a week
 
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agram said:
Oh, forgot to mention two electro cardioversions.

My heart was fine before. I think that I may stand alone in this, as most folk don't seem to have had such serious reactions. But there could very well be a certain amount of people that these things could happen to? Eh, who the fuck knows.

Shame the best research we can do with these RCs are human labrat reports PS.
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If the p-methylephedrine metabolite is produced in significant amounts (we know it is excreted in urine of meph users) and if like heavy use of ephedrine it produces cardiac damage then heavy use of mephedrone is likely to cause damage. There can be quite a lot of damage before things become noticeable. there are a lot of ifs, but it is possible that meph has done quite a bit of cardiac damage amongst the heavier users. Most heavy meph users are young which will help. Most people though don't have before and after scans, but there are scattered anecdotal reports online of strange ECG and echocardiogram results in meph users.
The good news is that usually ephedrine induced damage went away after several years.
 
did a small amount of meph 3 weeks ago and still having minor palpitations. they've never lasted this long before. all tiredness etc has vanished, but these palps wont go away. might go doctors, but i assume all they'll tell me to do is avoid all stims
 
I just reckon avoid this shit after what I've been through.

I was always the 'lighter' user of the group at parties, but I came off worse. It may have some interaction with certain people that it doesn't with others.

I've read, known and been told about folk taking quite litteraly twenty-fold the amount I've had in my life and have had less bad effects. It certainly wasn't an allergy for me though.

I did try Methylone a few times and had great fun, but with no bad effects. Odd.

I'm glad it's now illegal here in the UK, but it'll likely turn into a shitty cut drug sold on the streets, considering how much so many must have left ove from before the ban.

Bring back the MDMA, bring back things that have been studied! Not that I'd likely take them, as my curiosity has vanished, and it all seems the same.

Cheers prohibition, you've probably had more to do with giving me heart disease than mephedrone. Without seeming to have been predisposed to heart issues, I've had some fine times on LSD, MDMA, the occasional snort of smack and good coke...

Eh, I have a lot of journalism experience. Perhaps I may try and get some articles published ((at a a seemingly good time, recession, getting high off the counter, et al) promoting either a tollerance system or a call for more research. Then again, a fat load of good would come of that, no matter where it was published.

A billion dollar/pound etc war on drugs that kills people, and a billion dollar drugs industry that kills people. This is just fucked.
 
do we have any info on how the former meph users are in Israel? I remember reading that over there it was popular a few years before the UK craze...
 
Seems like i picked a good thread to jump in on. :)

Hello everybody :D After being introduced to 4-MMC a few months ago i decided to start looking into it. Have i tried it? Yes. Was it fun? Yes. Did i have any negative side effects that would cause me personally to stop taking it? No

That being said i normally do quite a bit of homework before trying something new. In this case I didn't and shame on me for it. :/

I have noticed the bluing reaction occur in some people's lips, but nothing beyond that in my circle of acquaintances has been brought to my attention. My initial use started off with an oral dose of approximately 250mg and was followed up with 2 or 3 bumps. I found it fun, but it seemed like too much in the sense that i felt i could achieve the same with less. So over the course of the last few months i have scaled back and found that i have very nice results with an initial dose of around 100-125 mg insufflated with additional doses every 2.5-3 hours. Normally the follow up doses are also snorted and are between 50-75 mg.

Although several people had reported having negative effects when combined with cannabis i found that to be entirely opposite of what i and several others have experienced. Cannabis actually made it a tad more empathogenic and added a very nice, but mild euphoria to things.

There is some anorexia the next day, but by day two afterwards it's gone. I have not noticed any troubling aftereffects, but i also have not used more than maybe 400 mg in once session. Water intake is important as is making sure to eat well prior to ingestion. As i feel that it causes more than usual potassium and calcium depletion (can't tell why, but it's a hunch) i also have recommended milk/calcium intake before and during and some standards like bananas and citrus fruit.

I am in moderately good health. No smoking, no drinking, some cannabis use, occasional use of other entheogens or recreational drugs. Lots of exercise from a variety of sources, lots of organic whole foods, and fresh air. The only persistent side effect for me has been the anorexia and that really doesn't last more than one or two days at most. Otherwise I have a generally elevated mood and energy levels for at least several days afterwards.

My sleep is only a bit difficult immediately afterwards, but even then after one good night of sleep it's back to normal. While i don't get "the blues"/depression from MDMA i find the next day can leave me feeling more physically and mentally tired. This is much milder, if present at all, with 4-MMC. In general i don't seem to suffer ill effects from stimulants, so take it for what it is worth.

It does have hyperthermic effects on me, but about on par with MDMA, although i sweat a little bit more on it when i do get into sweating. Tactile sensations are very present and very fun, but it is less emphathogenic than MDMA. On the other hand it does seem to be a potent aphrodisiac for some and i am one of them. ;) I find it easy to communicate on and I am a bit more talkative from feedback, but that's only noticeable to people who know me very well.

Sorry for the rambling.. it just occurred to me that this is a good case study to demonstrate how wide a range of reactions people can get to the same compound. I was noticing while reading through the thread that several of the individuals that reported having generally more negative reactions to the 4-MMC also seemed, from my observations, to respond to stimulants in ways that I do not.

Maybe there is a case to be made for genetic compatibility/susceptibility with this drug? As with all drugs. Being "only" anecdotal i can recall from personal experience that cocaine, for example, will allow me to be a very attentive listener and very calm. Not the response many people get from it. ;)

I am glad that some warnings have been posted about the drug though as we should all do our best to stay educated about these things. Some of the amounts that people have been using flabbergast me though. 3,10,20+ gram binges or frequent use? The only drug i would consider taking in those amounts is cannabis. Even with researched drugs i wouldn't ingest amounts that some people have.

thanks to all the contributors. I actually did read the first 25 pages. :) With all the additional information in hand i will also advise people of potential risks and rewards of doing this still very new drug.
 
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Does anyone have access to this:

Curr Drug Metab. 2010 Jun 1;11(5):468-82.

Metabolism of designer drugs of abuse: an updated review.
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That's only a review so it won't contain any thing new to Meyer's "Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry" paper. Which is summarised at http://en.wikipedia.org/wiki/Mephedrone#Metabolism
 
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AlkaloidsEye said:
After being introduced to 4-MMC a few months ago i decided to start looking into it. Have i tried it? Yes. Was it fun? Yes. Did i have any negative side effects that would cause me personally to stop taking it? No
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the longer you use it you'll start to notice the negative effects. they dont come immediately
 
38 grams between 6 people, some taking much more than others in 3 days, no fatalities. I think some people are just allergic to it, the others are the dumbasses who mixed with it.
 
Virtuoso said:
I'm a bit late to this conversation, obviously, but with the recent increase in meph availability (I was offered it at a party, for Christs sake), I feel it is necessary to point out that while the drug certainly can have quite terrible negative effects, for the majority of users it will not have any appreciable long term consequences. Granted, you don't know if you are going to be in that group who is highly sensitive to the drug, and while I have used it (and never gotten above 400mg in one session of usage) without any negative consequences, it seems important to note that this drug doesn't seem any worse than meth.

Take that for what its worth, obviously. Like all drugs -

Moderate usage + Self control

Will more than likely lead to a night with few consequences. Not saying that mephedrone is a wonder drug thats perfect in every way, as it obviously has some very real potential consequences, it seems that the issues that have arisen have come from the fact that, since it isn't explicitly scheduled, people don't take it as seriously or treat it with as much respect as a "real" drug like cocaine. If that hurdle were successfully jumped, I doubt we would see hardly any of the issues we have seen in the past with this drug.
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moderate usage + self control ? :) hahh
i came to realize there isnt such thing when taking meph
i was CLOSE pretty darn close to go to sleep 8-9 hours ago ... and then i said well ill be up anyway for 2 more hours ... im just gonna do a small line :)
the "bag" is almos gone now .... my nose is stuffed and aches and swollen and my throat aches too when swallowing and my mouth is a bit numb, and i have to go to work in 5 hours :((
i just hope it will be an easy day and none will notice my dripping fucked up head ....
but you can always try moderate usage + self control .... :)

edit: WOW ... MILK does wonders really ! thanks for the one who recommended it, it made my throat pain go away and also lubricated my mouth , so its not like a desert now :) thanks again
 
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activity111 said:
moderate usage + self control ? :) hahh
i came to realize there isnt such thing when taking meph
i was CLOSE pretty darn close to go to sleep 8-9 hours ago ... and then i said well ill be up anyway for 2 more hours ... im just gonna do a small line :)
the "bag" is almos gone now .... my nose is stuffed and aches and swollen and my throat aches too when swallowing and my mouth is a bit numb, and i have to go to work in 5 hours :((
i just hope it will be an easy day and none will notice my dripping fucked up head ....
but you can always try moderate usage + self control .... :)

edit: WOW ... MILK does wonders really ! thanks for the one who recommended it, it made my throat pain go away and also lubricated my mouth , so its not like a desert now :) thanks again
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i drank so much milk when i was on mephedrone. the fact you were abusing it the day before work shows the kind of drug this is. its hard not to use meph compulsively and to start binges on impulses and whims.

its best to avoid it as moderate use is hard to do and a rare thing:\
 
Had the chance to do some mephedrone a few weeks ago. I didn't. My friend snorted some and his nasal cavity became so swollen to the point of closing. That's about all I know.
 
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