• 🇳🇿 🇲🇲 🇯🇵 🇨🇳 🇦🇺 🇦🇶 🇮🇳
    Australian & Asian
    Drug Discussion


    Welcome Guest!
    Posting Rules Bluelight Rules
  • AADD Moderators: Tronica

So who has used Tramadol?

Could you both give the dosage of tramadol you take before the tramadol, and the time before codeine administration. Drug mentor said an hour before. is that the same with you?

Well tramadol takes a while to work and if taking codeine on an empty stomach it usually takes it around 20-25 minutes for me to feel the codeine euphoria.

So i'd personally take 100mg, wait 30mins, take another 50mg and then take the codeine around an hour and a half from my fist dose of the 100mg of tramadol.

1 hour and 25 mins in and i get a nice codeine warmth head buzz thats noticeably potentiating
 
When I had access to tramadol I would use 150-250mg to potentiate codeine. I also read that having tramadol in the system increases the bioavailability of any tramadol consumed later. Because of this I would try and dose 50-100mg an hour and a half before the codeine and 100-150mg about 50 minutes before the codeine. As having a very empty stomach is a large factor in codeines effectiveness for me, there were many occassions I opted to just dose all the tramadol at once so I could dose quicker. I would definately say spreading doses does work better, but not significantly so.

I had dabbled with oxy a number of times and used heroin once or twice before I started doing this, but it was spread over a long period and I had no appreciable opioid tolerance. With my current tolerance I imagine I would be taking larger doses than I was and any opiate tolerant people would probably want to go closer to 400mg.

Unless experienced with opiates I would try maybe 150mg on top of your usual codeine dose and see how you go.

Tramadol in general seems to be a bit hit and miss where some people get good effects and others get fuck all. Everytime I used tramadol to potentiate codeine it worked wonders, but an ex acquaintance of mine who was a CWE addict used to claim he go totally random results everytime like sometimes he would nod and others feel fuck all.

Tramadol is definately a pretty unqiue drug, and its not something you want to get hooked on. I imagine withdrawing from a mild opioid and and SNRI at the same time would be unpleasant to say the least.
 
^
I also found tramadol to be very good potentiator of other opiates during the brief time I had access to it when I was scripted it for several broken bones in my hand.

Never dosed more than 200mg by itself and never really experienced a noticeable buzz or high either, it definitely helped with dulling some (not all) of the pain though. I combined 150mg tramadol and 30mg oxycodone and found myself much higher than I would normally have been off 30mg oxy alone.

So be careful when mixing tramadol with other opiates, start low.
 
Actually I had a really good experience with tramadol once and once only but I forgot all about it.

Had a camera shoved up my arse at the hospital. Anyway they erase your memories with propofol. Apparently you're awake during proceedure, but aftwards you don't remember a thing. That's the drug that got famous due to Michael Jackson OD'ing on it.

A couple of hours later I started feeling some pain so I ate 2x50mg tramadol and after that kicked in it was more like a morphine hit, warmth, euphoria, sedation & just very pleasant, and nothing at all like tramadol.

Not that propofol and tramadol are a realistic combination but yet another strange quirk of tramadol.
 
I find tramadol to be closer in recreational effects to amphetamines than opiates. There is an opioid feel to it, but it is overridden by it's stimulant effects. A benzodiazepine is complimentary in doses over 300mg.
 
Actually I had a really good experience with tramadol once and once only but I forgot all about it.

Had a camera shoved up my arse at the hospital. Anyway they erase your memories with propofol. Apparently you're awake during proceedure, but aftwards you don't remember a thing. That's the drug that got famous due to Michael Jackson OD'ing on it.

A couple of hours later I started feeling some pain so I ate 2x50mg tramadol and after that kicked in it was more like a morphine hit, warmth, euphoria, sedation & just very pleasant, and nothing at all like tramadol.

Not that propofol and tramadol are a realistic combination but yet another strange quirk of tramadol.

Everyone loves propofol it seems. Such a pleasant drug (subjectively.. it is ofc very dangerous), no wonder MJ got hooked ;)

Regarding tramadol, I tried it once and it was ok. Nothing special.
 
Taking the doses (tramadol) at increments of half an hour will increase the opioid effects one gets from dosing, because the body metabolises more of the Tramadol into odesmethyltramadol (The 200xpotency good stuff!) the more Tramadol there is in the blood stream.

So basically, dosing 200mg at once will mean that the body will have to metabolise it all at once, whereas spacing out the doses in to say 3 or 4 at half hour increments will allow a
concentration of Tramadol to build in ones system and therefore more of the powerful metabolite will be created

I don't get it... unless your saying there is a limit to how much the liver can metabolize into O-desmethyltramadol at once and so needs some spacing in doses to convert more of it?
 
It is because for whatever reason, having tramadol already present in your body will make it metabolise any subsequently dosed tramadol into O-Desmethyltramadol more effectively.
 
Interesting, I might have to look into that... is it because tramadol is possibly a CYP2D6 inducer? In which case I can see how it might potentiate codeine nicely.
 
^yeah i've definitely read a journal or excerpt somewhere within an article about tramadol being more efficiently metabolised with the whole staggered dosing. i can't remember the exact reason how or why but i should be able to dig up what i read, i'm pretty sure i've got the page favouritededed.

for instance i definitely notice a difference in efficacy if i've been dosing only 2 x 150mg a day for a week and then the next week dosing 3 x 150mg. i'm sure the peaks and troughs of plasma levels play a role. but this is all speculation on my behalf without double checking, which i should do;)
 
Pharmacology of Tramadol

Tramadol Hydrochloride
(Zydol, Tramacip, Ultram, (Ultracet, Tramacet - when combined with APAP)

Effects

* Tramadol causes instant inhibition of serotonin and norepenephrine reuptake. This leads to increased feeling of wellbeing and happiness.

* Tramadol itself acts weakly on the μ-opioid (μ is the greek letter Mu) receptors (the ones responsible for euphoria and analgesia).

* Now, once the Tramadol has been metabolised in the liver, it's M1 metabolite (odesmethyltramadol) then binds to the aforementioned opioid receptors causing a much more powerful euphoria (200x more potent than that of morphine), however, the amount of odesmethyltramadol is quite small, so the potency is relative.

* The metabolisation must be considered, because not everyone metabolises Tramadol in the same manner, some barely metabolise any into odesmeth... hence many complain that Tramadol is ineffectual. This is the reason why usually.

* Also, the high from Tramadol lasts longer than that of most other opioids, sometimes up to 16 hours.


Forms

* Capsules (regular and extended release) (Doses usually ranging from 50mg IR (Instant release), 100mg SR (sustained release) to 200mg SR)

* Tablets (regular, extended release, chewable, low-residue and/or uncoated tablets that can be taken by the sublingual and buccal routes)

* Suppositories (bypasses hepatic demethylation)

* Tablets and capsules containing (acetaminophen/APAP), aspirin and other agents. (for analgesic synergy)

* Effervescent tablets and powders

* Ampules of sterile solution for SC, IM, and IV injection (bypasses hepatic demethylation)

* Preservative-free solutions for injection by the various spinal routes (epidural etc) (bypasses hepatic demethylation)

* Powders

* Liquids with and without alcohol for oral and/or sub-lingual use, available in regular phials and bottles, dropper bottles, bottles with a pump similar to those used with liquid soap and phials with droppers built into the cap.


Pharmacokinetic Information

* Bioavailability = 68 - 72% (this increases with repeated dosing due to increasing amounts of o-desmethyltramadol)

* Half life = ~5-7 hours

* Metabolism = Hepatic demethylation (to odesmethyltramadol) & glucuronidation



Side Effects

* Drowsiness

* Fatigue

* Constipation

* Dizziness

* Nausea

* Vomiting

* Dry Mouth

* Headache

* Indigestion

* Seizure (Usually only with overdose)



Serious contraindications - Important!

* SSRI medications can cause too much serotonin to build up in the brain and cause the deadly Serotonin Syndrome! AKA Serotonin Storm!

* DXM (Dextromethorphan Hydrobromide), because it has Serotonin inhibiting properties and can cause the same syndrome as above.

* Atypical antipsychotics are also at great risk of causing dangerous interactions when combined with tramadol.



Other notable information

* Any other route except oral bypasses the hepatic demethylation, weakening the opioid effects of the drug.

* Tramadol possesses recreational value for some people, when taken at increments of 50mg per half hour (this increases potency, see earlier). For opioid naive people, max dosage to start with 100mg. Never take more than 400mg in 24 hours, this could cause seizures!

* Although not often warned or mentioned by prescribing doctors, Tramadol DOES have an addiction profile and should be considered an addictive substance if abused
 
what what in the butt?

Hey,

I have ampules of 50mg/1ml tramadol. Is it possible to drink this instead of SC/IV injection?

Thanks


yes you can and its obviously a wiser choice in terms of harm reduction. Keep in mind 50mg is a relatively mild however safe dose to start. As has been previously stated dosing at intervals of one hour will raise the bioavailability. A total amount of either 100mg or 150mg over 2 or 3 hours respectively is what i would recommend.

i imagine it may taste horrific so if you fancy playing about, pour(may need to use a syringe to draw the liquid out) it onto a flat dish and allow the solvents to evaporate. If your careful you can then scrap put the resulting powder into a capsule or piece of paper to swallow. Also powders can be very illusive. PLEASE do not evaporate them all at once rather evaporate each ampoule onto a separate surface so you can keep track of each 50mg dose. It may seem tedious but you don't want to be ingesting unknown piles of powder.

I see many different conflicting believes about the hepatic portal system. The applications extend to codeine and the same issues come up about its ROA. Obviously I agree that iv/im (contraindicated for codeine), sublingal and nasal bypasses the first pass hepatic effect however what about rectal.

Ultimately it comes down to "if i put this up my butt will i get high?"

inferior mesenteric vein does reach to the rectum as you can see in grays depiction

http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png

Maybe its a matter of everyone being different but that seems like a cop out, can any clever person out there give me an answer

p.s if you extract the tramadol to a powder form resist all temptation to snort it. It both burns and is hugely ineffective.
 
Last edited:
I've never used it, but I remember reading that it can be a very hit/miss drug, some people getting a nice buzz off it and others not getting a whole lot.

i have to agree with this post as i have read about many peeps on here useing it and loving it .
I myself had a whole bottle and took quite abit and it didnt even aleviate any of my knee pain so i just tossed them and went back to the T3s...
 
I've been using tramadol daily since march 2006 for my chronic severe pain I've had from a motorbike injury. All the doctors back then were praising it for it's "non narcotic drug that gives somewhat close pain relief as narcotics. Non addictive yada yada yada blah blah blah"

The first dose I had I found was "fun", subsequently, every dose has just been pain relieving with no recreational or other (side) effects. Most friends who have tried it for recreational use have had the same experience, the first dose was fun but subsequent dosages were not fun at all, just there for pain relief. Though, one friend "gets off" on it most if not all sessions he has with it, usually 1-2 X 200mg SR tablet. He LOVES the feeling and is fairly well versed with the usual suspects of recreational drugs.

The worst thing about tramadol for me was it's WDs. It's the only drug I've actually had WDs. I was on up to600-800mg (maybe more, I was dropping 80mg OCs "like nothing" when I first sustained the injury and was in PAINSVILLE plus my GP was illegally prescribing them without authority for up to 6 months and then medicare/aussie health? caught up with him and spanked him somewhat hard for doing so much prescribing to me heh. Anyway.. I insta stopped the roughly 600-800plus? oxycontin for days/weeks with no obvious WDs, I was still taking tramadol so that could have been helpful.. Anyway, back on topic)

One Xmas, 2 or 3 years ago, I decided to stop my daily tramadol so I could see how I went with other pain meds. Woah, 2nd day off tramadol, BAD heavy flu like symptoms, bed ridden and I was shit house until I took tramadol again and WDs went away. Still on tramadol to this day, I do sometimes stop, 1 day at most, my BD is 1 X 200MG SR tab, sometimes 1 at night, I have had up to 400mg during a 4-6 hour period with BAD pain and not wanting to have oxycontin (Im using it again since I had major surgery and pain had been bad ever since). I will taper down with "insta hit" tramadol once I do decide to go off it, if my pain ever subsides enough for me to feel to do this.

The short, if you're on prolonged (daily) use of Tramadol HCL, be prepared for some nasty withdrawals. Interesting since ALL my doctors (probably had 8-10 specialists dealing with me and my brachial plexus [nerves in shoulder] damage. I had neurosurgeons, neurologists, physiotherapists, occupational therapists, 'managing surgeons/doctors' who found other doctors/surgeons whom were the best to see for my various treatments + recovery), all of them praised how good [and non addictive] tramadol "should be". Oh well, it's mucho easy to prescribe daily use of a drug if you're not the one taking it or a valued family/friend heh.

And excuse any hard to read grammar, I'm actually going for a job interview tomorrow, a kick arse managed network sysadmin at a 'high level IT security' joint, they know of my ongoing pain and injury, should be happy for me to work at home to do said managed work, I 'sit and wait' for alerts from the managed networks (monitored by nagios software afaik, I'll find out MORE tomorrow) and when I get any alerts, examine and/or fix what needs to be done. If I can't do it via remote login/VPN stuff, I'll drive/ride to the client and do the work there. So, I still have my mantra of being at home for my childs (well, children, second + final is on their way, May next year :D) upbringing/growing in their early years, I DO NOT want to be working "hard for the man" and missing their lives, no fuggin way... But a job like this, big $$$, work from home and a friend who recommended me for the job LOVES this workplace, he is FUSSY and has left quite a few "good jobs" simply because the workplace/attitude sucked in his view, so I _know_ I will love working here. If I don't get it, np, I have a fallback job from the place I'm at now, it's work from home but atm, it's LOW work, like 1-2 jobs in as many months which will eventually build up to full time work in 1-4 years as they grow and need me to be the network + system admin to build their networks.

So, my head is full of Cisco IOS + *nix commands + best practices, I'm routing for the team *boom tish*.. So, as said, sorry if this post is full of crap and hard to read, my head is in a "work" headspace, I'm not here often, atm I'd be watching some docos or _good_ movie or the seldom tv show we watch, or PS3 or reading. Not doing research on computing stuff I first started 20 years ago. It feels like year 12, cramming for my final exam tomorrow LOL. At least I'm told "It doesn't matter if you don't know it all, we just need to know you have a solid unix + networking foundation so we can train you in our propriety software and anything else lacking to bring you up to speed. Sounds great, lets see how tomorrow goes :D

I wish you all well who enjoy tramadol, it works great for pain relief for me actually. I get "better" pain relief (read, not the fun like I do with oxycontin), I actually get less pain relief from oxycontin but it helps "good" with the breakthrough pain after my morning dose of 200MG TRAMADOL SR tablet, sometimes 2 x 665mg paracetamol SR tabs and MAYBE iboprofen + codeine tabs if I am having a SHITHOUSE day, OC comes 3-5 hours later (around 11am-2pm) to sort me out for the day/afternoons jobs of cleaning, exercising, playing daddy, riding the mbike and whatnot that keeps me busy day to day.

*salute*, my 80mg temaz BD I just took before is kicking in, Im off to bed for a 5amish rise so I can refresh myself with the enable, sh ? commands of cisco along with route, netstat, nmap, lspci, dmesg etc stuff I'd use to see how an "unknown" computer I get a hold of is doing. Also arp, traceroutes, checking out /etc/init* rc.* etc, hopefully that quick stuff and mentioning cisco ACL and enabling root stuff will show I'm not a "gen x" linux GUI ubuntu lover who has no idea what "command line" actually means. Heh, sorry for the rant, my head is fll of geek stuff atm, I bid thee all farewell for now and I think I may keep my head inside of here, still seeing phase_dancer brings a warmth to my heart not that many other "net buddies" do :)


I dread spell checking, so I won't :P
 
That's a very heart warming comment Wazza. Nice to hear you're happy as a stay at home Dad. It's such a magical time, isn't it :)
 
tramdol is only a quasi opiate according to pharmaceutical standards..It only has binding affinty with 3 of 4 main opaite receptor sites,and the one it does not have any binding to is the one that produces most of the euphoric effects.Tramadol is more of a sedative with some opiate properties..it is missing the best one of the 4...look it up in a PDR if you do not believe me..Not downing tramadol but just informing..
 
most sources i've seen classify tramadol as an opiate, a-typical by some others.

it does act on all opiate receptors, as well as SERT and NA effects which synergise the painkilling effects it produces.
 
Top