Ok, so naloxone, if taken orally, won't cross the BBB, but it still will antagonize the receptors in the gut. If you were to injest naloxone, wouldn't that ease the constipation? I realize it's only available as an injectable liquid, but it can still be swallowed.I know that a combination oxycodone/naloxone pill is already available is most of Europe, called Targin.
Or maybe Methylnaltrexone, Relistor, which was also just introduced for this very purpose. It looks like this is only allowed to be prescribed for people with advanced chronic illness though. Although both naloxone and Relistor aren't scheduled in the US.
Which would be best to ask a doc for a script for? Her doc has never even brought up any of these, so he probably doesn't even know about them.
My mom is currently on Oxycontin 20mg 3x daily and has serious constipation issues and the same problem as the OP. All they keep putting her on all stool softeners, but it doesn't help her much. Which do you think she should ask for? I feel bad for her.