How toxic is Mephedrone?

[MikeHawk]

No offence but you sound like a little queer.

How is that constructive? How is that not offensive? Fuck off.

Dude, ffs you've only done 8 grams. If anything it takes someone a few times to take a drug to get the benefits. Well this is true for me haven taken a whole array of different drugs.

I think you jump to conclusions far too quickly. It sounds more probable that the bad synthesis you suspected, would be why you believe meph to be insidious

BTW 5+5=10 NOT 8 grams!!

I've had two orders of 5 grams, I've not finished the second order, the fuck?

It doesn't take a couple of times to take a drug like this to get effects, what the FUCK are you talking about? I've had amazing effects from Mephedrone in the past but it's diminished rapidly and there's a huge amount of evidence that it's very toxic now, unlike 6 months ago, which is when I first used it.

Stimulants are not like downers or cannabinoids. You do not learn to "appreciate" the effects. The effects are in your face, it's ludicrous to suggest one has to consume 8 grams before they can appreciate Mephedrone's effects. Please for the love of God someone agree with me that this idea is completely idiotic.

 

[egor]

^entirely

 

[nolys]

Stimulants are not like downers or cannabinoids. You do not learn to "appreciate" the effects. The effects are in your face, it's ludicrous to suggest one has to consume 8 grams before they can appreciate Mephedrone's effects. Please for the love of God someone agree with me that this idea is completely idiotic.

of course they arent i have to agree with this 100%. Look at MDMA. 99% of people say that their first time was their best time so how can it get any better? Same applies to mephedrone, it hits you clean in the face like a brick wall

 

[MikeHawk]

Glad to hear people echo my view. Slackhands, please don't post garbage. It could genuinely damage somebody's health if you put misinformation on a harm reduction forum.

 

[ColtDan]

i agree with you, the effects are instantaneous. first time i did it it blew my head into the heavens of euphoria

 

[Mailmonkey]

Glad to hear people echo my view. Slackhands, please don't post garbage. It could genuinely damage somebody's health if you put misinformation on a harm reduction forum.

If slackhands didn't post garbage he wouldn't really exist.

Just put the cunt on ignore.

 

[adder]

The situation with mephedrone in my country has become even more worrisome than it was with methcathinone. I remember this wave of people who had no contacts to buy amphetamine and methamphetamine is just unobtainable in most places, you really have to have good contacts to get it here. The problem with methcathinone was that it was cheap because people didn't buy anywhere instead synthesizing it themselves adding at face value KMnO4 (a strong oxidant) to a solution of tablets with pseudoephedrine hydrochloride. And it was acidified during the process with 10% acetic acid. After getting rid of brown MnO2 and other shit it was injected mostly but some (well, both were "heroes"...) drank it. Not to mention methcathinone is likely to be redosed multiple times because of its short time of duration.

I'm not saying that I never tried synthesizing methcathinone (with adulterants of course) with this method or that I never shot it. But it can be easily and safely synthesized in a laboratory yielding hydrochloride >99% pure. But the world is not full of chemists, right?

Now, mephedrone. This doesn't even make anyone with no chemical experience read some idiot's bullshit called "synthesis". Prices are ridiculous (well, converted to dollars maybe it's nothing but here in Poland this is well overpriced), 1 gram costs 90-100 PLN, 0.25g costs ~30 PLN (1$ = 2,84 PLN). Well, something is going on, at last. The site that offered quantity of even 10g of this shit and also started selling 3,4-methylmethcathinone is now down. Who are the clients of these "shops"? You don't have to think for long that mostly those are young people who need a high but can't buy any other stimulant or drugs in general and they heard only tales about crystal MDMA. So they go and buy this surely much more toxic amphetamine analog.

Shops with stimulating "whatever" are another problem. They sell BZP and TFMPP in mixed ratio under numerous names. Anyone who knows anything about chemistry and neuropharmacology knows that piperazine derivatives are hell of a toxic shit.

Well, I guess this is where we end up making drug illegal in general, still having legal alcohol or nicotine which are much more toxic and addictive than a lot of recreational psychoactive substances.

 

[MikeHawk]

I do seriously think the Mephedrone stuff may prompt a few governments to at least consider lessening regulations on MDxx as this is what causes the problem. Mephedrone WAS at least a worthwhile substance unlike BZP. It's unfortunate it took a few other interesting substances like Methylone and Butylone down with it, but I think reports of their potential are exaggerated.

For example, every time I ingest Butylone I get bulging veins, especially in my feet. I also get pain in my feet. There are veins that appear that I've never even seen when I'm on Butylone so I find people's claims that Mephedrone is more toxic a little ridiculous. Thankfully Butylone and Methylone give clear warnings when you've had too much, unlike Mephedrone.

I hope that something fills the void quickly that's non-toxic and worthwhile. MDAI looks encouraging but maybe something with a little DA activity too.

 

[adder]

MDAT is an interesting compound but anyway I don't see people selling mephedrone start selling such compounds like MDAT and other related. They don't have hell of an idea how to synthesize it...

Methylone isn't bad. It doesn't feel like MDMA but it's no comparison for mephedrone which is... What? I really see no cause for taking it in any form and via any ROA other than not having access to now illegal stimulants/empathogens. Mephedrone may pretend to substitute for them but it doesn't, shit for me, making more and more harm in general. I don't think banning it finally will push any government to make any MDx(x) legally available in any way. They're going to keep banning another compounds and those "dealers" will reappear with more dangerous and shittier compounds. Waiting for another "Age of Love" is pointless in my opinion. Long time ago even when MDMA was already illegal one stupid pill was enough to bring this magic and now people take sometimes tens of them because there is little to zero MDxx inside, instead containing some amphetamine speedy stuff.

The world goes to pot.

 

[MeDieViL]

Is it possible that mephedrone upregulates the α2-adrenergic receptors? I dont know wheter those can upregulate in presence of a agonist.
Its the only explanation i can think of for the vasoconstriction returning when taking another stim post meph use.

 

[enduin]

It would also explain what I was talking about in the long term toxicity thread, like heart hyperexcitability and palpitations in reaction to normal stimulation like after lunch, under stress, etc.

 

[adder]

My lucky guess from what I remember is ligands can cause upregulation of both {alpha}1 and {alpha}2 adrenergic receptors.

Well, such a process would also be an answer to some questions regarding severe opioid withdrawal, massive release of adrenal gland hormones leading eventually to adrenal gland distress.

 

[vortex30]

slackhands is an idiot, no problem with your posts. I easily understood you had one 5g order, then another 5g order you've done 3g from. Probably didn't understand 1/4 of the words in your first post, thus the queer remark. Intelligence must be a sign of homosexuality, makes sense considering the most 'flamboyant (or opposite word) heterosexuals' seem to hold very little capability for intelligent thought, their minds are on repeat 'sex, sex, sex...' ad infinitum, Idiocracy is a good film on this phenomenon.

Had another hoo-rah with the old Mephedrone after a day on MDA and then a night on booze and alprazolam. Lasted about 28 hours, was up for 44 hours total. By no means my heaviest sess, but towards the end was hallucinating slightly and felt horrible. Terrible feelings next two days. Back on the grind and 9 days off the stuff again. Probably consumed 1.5g in the session, though it's hard to say as I was blacked out on benzos most of the time. Slight reddening of the knuckles and purpling of the knees, which had entirely gone away before this session, returned and is still around albeit lessening now. Will probably take 2 weeks to fully clear up. Highly doubt this is classical vasoconstriction, as I NEVER experienced it for months of sometimes heavier mephedrone use. I think its that reaction some people have to pseudo-ephedrine, which makes their skin go red, probably made worse by meph's vasoconstriction? It's very weird though. Glad I'm done with this shit...Kinda. I've got 25.5g or so, gonna sell it all is the plan. May have one last session on it, who knows.

I seem to have been able to abuse Mephedrone for longer and harder than most people, yet I'm not alone. I belong to a community of mostly UK based, HEAVY users, and very few are experiencing short-term problems, anyways. It's strange, a very hit or miss drug in terms of acute side effects, that seem to get worse with time but for some never really seem to crop up. Long-term effects though, we're probably all fucked when those come around.

 

[adder]

heterosexuals' seem to hold very little capability for intelligent thought, their minds are on repeat 'sex, sex, sex...' ad infinitum, Idiocracy is a good film on this phenomenon.

Oh really? Then I must be an exception to this rule. And wow! I would easily find a lot of exceptions. Then it's not a rule. I'm so sorry. And by the way, is this a thread in ADD or am I blind and it reads 'trip reports'?

 

[vecktor]

Oh really? Then I must be an exception to this rule. And wow! I would easily find a lot of exceptions. Then it's not a rule. I'm so sorry. And by the way, is this a thread in ADD or am I blind and it reads 'trip reports'?

there is another rule which states that sarcasm doesn't work online... 8)

 

[MephMan9834]

I must say glad its getting banned i got my self in a right mess started off doing it every weekend about 3g but i just wanted more every weekend became every day and to fund my addiction i turned to dealing the drug illegally next thing i knew i was ordering 100g every week and making £1,500.00. but things come to an end when i nearly lost my job and people were just loosing it went to rehab to get off it and its been 4 months now since i touched it and my life is back where it is now happy

 

[vortex30]

Oh really? Then I must be an exception to this rule. And wow! I would easily find a lot of exceptions. Then it's not a rule. I'm so sorry. And by the way, is this a thread in ADD or am I blind and it reads 'trip reports'?

You took it right out of context, didn't you? I'm straight and intelligent too (who would have guessed from that post, amirite...)! I'm just not the type that goes and calls people out on being gay, you know, the 'ard lads, just got back from gym, doing lines off their fists in toilets every 30 minutes before beating up someone half - 3/4 their size, jocky cunts. THOSE are the people I'm talking about (and sarcastically, might I add). Not heterosexuals, as you quoted me as saying. Did you happen to miss the words before heterosexuals and the blatantly stupid contrast I tried to make, or did you just not understand what my whole point was?

Thanks, vecktor, fuck I wouldn't say something that stupid and actually mean it, it's a logical leap from what slackhands stated.

This is a thread in ADD. If you'd like to contribute all the hard scientific evidence you happen to possess on Mephedrone, it'd be greatly appreciated! (Yes, I know you were being obtuse, this is sarcasm again, just a little FYI) Until then, we're left with subjective, but informed, experiences and assumptions/hypotheses.

 

[Eliphaz]

Is it possible that mephedrone upregulates the α2-adrenergic receptors?

That would be consistent with symptoms lasting now two years after a long period of extreme stress combined with light mephedrone use a handful of times.

Recovery is veery slow, requiring tight food and life style control (eg. a couple of beers every few months is too much). Alpha-2 agonist like clonidine could help with fixing the upregulation right? That was my weak spot to begin with, and mephedrone apparently broke the camel's back... For instance got extreme agitation from miniscule amounts of the antagonist yohimbine while still being apparently healthy ages ago. I don't dare to think what effect that would have now, but hey the bottle should still be hidden somewhere.

 

[MeDieViL]

Yeah ive allways been puzzled how the vasoconstriction seems to be long lasting.

I dont know wheter clonidine would work, no idea what effect it has on the a2 receptors.

 

[junglist15]

I'm done with this shit after about 8 months of on and off using. Nothing really bad happened, the thrill is gone I guess.