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Bupe Suboxone/Buprenorphine FAQ & Megathread v2; 2010

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Sure we have the #3. But drug wise,imo, it isnt even a contest. All these oxy hydro codone morphone, never anything like that over here! Lots of cheap ketamine,mdma,lsd,2c-?,heroin, etc there is though..



Do you know how hard it is to get prescribed that! in uk its hard enough getting bloody codiene! Lucky find mate!

pcs085.jpg

lool
 
^Oh Boy! I'm getting a boner just looking at that pic!

The things I would do to get my hands on them Diamorphine Amps!
 
I've been tapering Sub for 5 complete days now. Tomorrow will be my 6th. I've been doing .5 mg for the first 3 days and switched to .25 mg on day 4. The way I've been dosing the .25 is when I get up and when I go to bed, so I'm still actually doing .5, but I'd figured it will make the transition easier, and reduce the anxiety and weird feeling in my head. I just took my .25 dose at 2:00 in the morning on day 5. Tomorrow I would like to try and not take a dose when I get up, but instead take .25 after 6 pm so I can make it through one day on .25. If I can I'd like to repeat .25 on day 7 only once. Day 8 I'm going to do 5-10mg of oxycodone. Day 9 I'd repeat the oxycodone with less, or if I felt alright I just cut off completely. What do you guys think? Am I trying to taper too fast?

BTW, I've been taking with noticeable success:
-Valerian
-Passionflower
-Multi-Vitamin
-Vitamin C
-Massive amounts of water

I might add alprazolam or diazapam after I cut off the opiates completely. Right now the Valerian and passionflower do a great job with the anxiety. Chamomile tea helps too.

You're not tapering too quickly. It's really up to you. It's a good idea to save the benzos for after all opiates are out of your system. Let us know how it goes!
 
Honestly man, my nerves are higher up during withdrawals and then they go down. But I'd definately not want to run out just a few days after using, but that's only because I find benzos to be so damn addictive.
 
what are yalls opinions on sub withdrawal compared to heroin? ive heard horror stories of people coming off sub (subsux.com) but in my exp. it is pretty much not even close to as bad, ive had weak flu symptoms and minor anxiety each time ive had to come off but i still havnt gotten past 7 days without redosing
 
man , this is truly "recreational" and for someone who always tries not to mess around too much with benzos/hypnotics for obvious reasons I've lately been finding myself indulging in this combo bigtime ...and even worse is that the effect I get from thuis stuff insuflated is prompting me to go out and get me a couple of needles and experiment this IV ...so,the recipe would be ...take around 2mgs of bupre sublingually after 0.5 Alprazolam(orally) ,after the bupre is dissolved take 12.5/25mgs Hydroxyzine(orally) while chopping 4 lines of 1mgs Bupre+7,5 Midazolam + 1mgs Loprazolam ... snort these lines and in 15 minutes you'll even forget H ever existed ...it's that AWESOME ...this Loprazolam/Midazolam/Buprenorphine/Hydroxyzine combo is by far the best way to get fukked up on Bupre ...potentiators,Synergysms ,whichever way you want to put it ...this combo owns me and I think I'm just about to succumb to the needle temptation cause of this hahah
 
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man , this is truly "recreational" and for someone who always tries not to mess around too much with benzos/hypnotics for obvious reasons I've lately been finding myself indulging in this combo bigtime ...and even worse is that the effect I get from thuis stuff insuflated is prompting me to go out and get me a couple of needles and experiment this IV ...so,the recipe would be ...take around 2mgs of bupre sublingually after 0.5 Alprazolam(orally) ,after the bupre is dissolved take 12.5/25mgs Hydroxyzine(orally) while chopping 4 lines of 1mgs Bupre+7,5 Midazolam + 1mgs Loprazolam ... snort these lines and in 15 minutes you'll even forget H ever existed ...it's that AWESOME ...this Loprazolam/Midazolam/Buprenorphine/Hydroxyzine combo is by far the best way to get fukked up on Bupre ...potentiators,Synergysms ,whichever way you want to put it ...this combo owns me and I think I'm just about to succumb to the needle temptation cause of this hahah

Well good luck man. I know midazolam is wonderful IV'd, however without a micron filter it might be better not to shoot pills. I'm sure that's the least of what's on your mind. But if snorting it works why not just stick to that?

It sounds like you found a pretty sweet combo all right. :)

I just had 7.5mg temazepam after 0.1mg buprenorphine.
 
sublingual better than IV?

hey guys ive IVd suboxone a few times now and in my expierience its better than taking it sublingually... wats the bio availibility? seems like i get at least 3x as high taking it sublingually and i hit the shots most def....anyone else expierience this?
 
^Bioavailavility for a drug administered IV is considered 100%, though you will lose some when you prepare it.
 
^jesus christ man, are you used to being spoon fed everything? i said the BA's are available on the first page. here's the one time i quote them for you

Originally Posted by jasoncrest
Buprenorphine bioavailabilities:

intraduodenal: 9.7%

intrahepatoportal: 49%

intramuscular: 68%
"The observed mean intramuscular bioavailability was 68%"
"Studies of buprenorphine bioavailability have also examined the intramuscular (bioavailability, 50%–100%)"

intranasal: 50%
"Studies of buprenorphine bioavailability have also examined the [...] intranasal (bioavailability, 48%)
"The bioavailability of buprenorphine, HCl (BPP) in sheep after nasal administration of two formulations has been studied. 0.9 mg BPP in 150 microl was administered nasally and compared to 0.6 mg i.v. The test solutions were formulated with 30% polyethylene glycol 300 (PEG 300) and 5% dextrose, respectively. The bioavailability for PEG 300 was 70% (S.D.+/-27%, n=6), whereas the bioavailability for 5% dextrose was 89% (S.D.+/-23%, n=6)."
"Mean intranasal bioavailability was 48.2 +/- 8.35% (mean +/- s.e.m.) of the intravenous value"

intrarectal: 54%
"bioavailability of the drug was found to be: [... ]intrarectal (54%)..."
"Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were [...] intrarectal, 54%..."

intravenous: 98%-100%

oral: 10%
"the oral bioavailability for buprenorphine is state to be 10%"
"due to extensive first-pass metabolism, buprenorphine has very poor oral bioavailability (10% of the intravenous route) if swallowed"

sublingual: ~30%
"Buprenorphine is well absorbed sublingually, with 60% to 70% of the bioavailability of intravenous doses"
"Study results indicate that bioavailability of sublingual buprenorphine is approximately 30%"
"Literature on bioavailability of sublingual buprenorphine presents variable numbers ranging from. 19–58% of the administered dose."
"Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were [...] sublingual, 13%"

transdermal: 15%

you're welcome

i've never used bupe tablets sublingually, only ever IV'd them so i can't comment.
 
yeah i can imagine sublingual would last longer. the oral bupe that i've used in the past has been a lot longer lasting than IVing.

mind you it was transdermal patches of bupe i was eating so it was still SR to a certain point which is probably why i would get a 24hr+ buzz sometimes. they were 7 day patches that contained 20mg of bupe, so it equalled roughly 2mg of bupe after taking BA into consideration.
 
yeah i can imagine sublingual would last longer. the oral bupe that i've used in the past has been a lot longer lasting than IVing.

mind you it was transdermal patches of bupe i was eating so it was still SR to a certain point which is probably why i would get a 24hr+ buzz sometimes. they were 7 day patches that contained 20mg of bupe, so it equalled roughly 2mg of bupe after taking BA into consideration.

Interesting stuff! Good to know.
 
Dude i'm getting so tired of buying fresh syringes.

The exchange by me only carries 28G 1/2" and i have to buy like 2 100 count boxes of 31G every month and a half or so.

I just cannot stand poking myself with those huge fucking needles but i will not use my 31's more than once.

I even get the 100 ct boxes of BD syringes for 14.99 each which is sooo far under msrp.

I'm debating going to my SEP and telling them am i likely to start sharing needles with HIV infected people if they do not meet my demands.
 
Dude i'm getting so tired of buying fresh syringes.

The exchange by me only carries 28G 1/2" and i have to buy like 2 100 count boxes of 31G every month and a half or so.

I just cannot stand poking myself with those huge fucking needles but i will not use my 31's more than once.

I even get the 100 ct boxes of BD syringes for 14.99 each which is sooo far under msrp.

I'm debating going to my SEP and telling them am i likely to start sharing needles with HIV infected people if they do not meet my demands.

Maybe you can travel to a different needle exchange? The closest one here is 3 hours away, one way. :(

I know what you mean though.

2 100ct. 31g lasts me < 1 month, so be thankful it lasts you 1.5 months lol!

Also, where do you find them for 14.99? Canada drugs now charges 19.99 each.
 
So I decided to go ahead and attempt the antihistamine/bupe IV. I've done it three times. Each time I went through 5 syringes, I'm so incredibly confused at how things are getting clogged!

I started by breaking up one 25mg diphenhydramine, added water and let it sit for around 10 minutes. I stuck a cotton on top, let it soak up the water and then drew it up in a syringe. I put the resulting concoction in the new spoon with the suboxone, mixed it up, put a cotton in. At those point, every time, I could only draw 5-10 units of liquid before it would get stuck. It took another 2-3 syringes to get all the liquid out of the cotton. There's no way in hell I'm going to stick myself 4 times to get a feeling I could similarly get through doing this all orally...it's also not exactly the safest method to then drain all this liquid out of each syringe from the ass end.

Why would I have this problem so late into the mixture? These syringes are so stuck I can't even push the liquid out of each one. Could this be the cotton? Maybe a chunk of pill? (seems most likely, though the mixture was clear even when it was in the spoon, I couldn't see any chunks big enough to get stuck)

Going to go stick one under my tongue...I'm upset I held out until 4pm just to fail several times in a row :(:(:(:(:(
 
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