Stimulants of the Future II

[Hammilton]

Can't say I've ever noticed a thread make it to nearly a thousand posts here before! Popular topic, I guess.

3-(Methylenedioxyphenyl)-morpholine, how about it?

And how about: 2-phenyl-3-ethylamino-tetrahydrofuran? (or methylamino, why not..)

And: 1-benzyl-1-ethylamino-cyclohexane?

Or ... b-keto-n-methyl-alpha-isopropyl-phenethylamine?

Or this: 5-methoxy-2-morpholin-4-yl-indan-1-one?

Sorry, cba to draw/upload pics. Mayhaps later.

 

[dread]

3-(Methylenedioxyphenyl)

oooops :O should be benzyl instead of phenyl, my bad...

 

[dread]

 

[Hammilton]

Why don't you read a few papers on the SAR of these sorts of things and then make informed rational suggestions instead of these empty and meaningless, apparently random suggestions? 5b couldn't make less sense to me. It'll probably be a dopamine agonist if I remember my D2 agonists right.

There have been so many papers on the subject, I can't understand not doing so at all.

These aren't even intergesting, because they've pretty much been covered to death.

 

[Smyth]

Some of the structures look good.

I suggest you start a page on wikipedia or something and properly explain the background using references.

It is rather presumptuous just to post structures without any real meaning.

1) You need to show you have a real solid grasp on the subject area.

2) You need to be able to communicate this effectively to others.

 

[c0rt3x]

What about "Amphenidate":

methyl 3-amino-2-phenylbutanoate



Methylamphenidate:

methyl 3-hydrazinyl-2-phenylbutanoate

Was it a potent DRI as well as a dopamine releaser? I think so.


Or maybe the next logical step of this group:

6-methoxy-3,4-dimethyl-5-phenyl-1,3-oxazinane


This one was like a structural mix of Methamphetamine, Methylphenidate as well as 3-Methylaminorex ("Mephenorex"):

6-methoxy-3,4-dimethyl-5-phenyl-1,3-oxazinan-2- amine

And finally :-D :

5-(2H-1,3-benzodioxol-5-yl)-6-methoxy-3,4-dimethyl- 1,3-oxazinane

 

[Smyth]

what is this shallow bs. post me some refs.

 

[c0rt3x]

I've just invented them - so I can't post you any refs....

 

[ebola?]

This would be more interesting (particularly to lay-people like me) with rationales (even if entirely unsubstantiated).

 

[Hammilton]

Yeah, you invented them. sort of the way children invent green cows when they're learning to color.

It's meaningless dribble. Whipe your face!

There should be a rule here: if you can't provide sound logic for why a structure merits discussion, you get slapped a thousand times and don't come back until you stop crying, preferably >3 weeks.

If you were to have done your home work, you could have logical reasoning for these structures, but you don't. I mean, some of them are incredibly pointless, so you couldn't, but you'd at least know this if you had.

Or maybe the next logical step of this group:

you mean illogical, no?

 

[Tchort]

My feelings are hurt just from reading this.

In the [near] future, meaning the next 10-20 years:

Will the synthetic stimulants manufactured in Chinese, Indian and other Asian labs in bulk and sold on the RC market grow to compete with the Yaba/Methamphetamine labs in the jungles of South East Asia?

Better phrasing: Will synthetic manufacturing from industrialized Asian countries supercede or at least compete with the archetype of illegal drug manufacture (Third World oligarchies/military dictatorships with backwoods peasants farming plants and harvesting their alkaloids/running low skill synthetic labs?)

Japan seems to be the only Asian country hungry for the former. The latter is showing dominance in the poorer or less developed areas of East & SE Asia.

I guess you could supplant this discussion to the West as well. Replace peasant with working poor or lumpenproletariet and jungle lab with basement/kitchen lab with OTC materials.

Unless the RC/synthetic market can pull another MDMA out of its collective ass, I don't see the Amphetamine Sulphate, Methamphetamine Hcl labs of Europe, N.America, SE Asia being mildly shaken.

 

[Hammilton]

All it takes is a change of preference. If the next generation of tweakers decides that meth is too dangerous (perception is huge) they could easily switch to some RC.

The problem is that meth is cheap as hell, and so are the precursors.

As far as I can tell, besides cocaine, none of these things are really coming from plants. Meth and amphetamine are entirely synthetic.

And it doesn't have to be a new MDMA, it just has to be something preferred to meth. Given the change in perceptions regarding meth, that doesn't seem far fetched at all.

If someone came up with a synthesis for fencamfamine that was as cheap as meth synthesis, I wouldn't be surprised if that became the big thing. Still, it's unlikely the needed precursors would be available, so there wouldn't be much of a homegrown market. It'd have to come from superlabs in developing nations. Africa could well supplant SE Asia as the big producing nation. With the movement of trafficking routes through africa today, that doesn't seem unlikely.

 

[permastoned]

Probably been said a thousand times but.. indanylmethamphetamine and napthylmethamphetamine. Or the non-methylated forms. WTB.

 

[mad_scientist]

Will the synthetic stimulants manufactured in Chinese, Indian and other Asian labs in bulk and sold on the RC market grow to compete with the Yaba/Methamphetamine labs in the jungles of South East Asia?

This is a fascinating question, whether a stimulant RC will come along that can actually replace meth or coke on the market rather than just being a crappy legal alternative. MDPV and DPMP both come close, but not quite good enough. The cheap manufacturing costs of methamphetamine really make it hard to compete with, but still it must surely be only a matter of time before a RC that is both good and easy to make comes along, will be most interesting to see what it turns out to be.

 

[vecktor]

The cheap manufacturing costs of methamphetamine really make it hard to compete with, but still it must surely be only a matter of time before a RC that is both good and easy to make comes along, will be most interesting to see what it turns out to be.

then the son of meth will be illegalised, and that will be that. nothing is going to be easier to make than meth, one step from available (with the right connections) and very cheap material

 

[dread]

I guess one shouldn't post on ADD while one is tweaking on MDPV.

Anyway, the idea was that the pyrrolidine gets very easily cleaved off from the MDPV. So I thought maybe a morpholine in it's stead would be more stable since it should be less strained. (Fig. 5a)

The phenyl-eth.amino-thf. would be a cyclic version of alpha-ethyl ethcathinone. Also structurally similar to cypenamine and fencamfamine. (2a)

No. 6 could be a decent stimulant. The rest, really don't make sense to me either.

 

[Hammilton]

Actually #6, would be interesting for an assay, but there's no way I'd spend money to have it made for myself. Also, when I say assay, I do not mean a bioassay!

At quick glance, my notes say: 1b, 2 yes (not 2c) 3a and b, not at all. 4 not at all. 5a probably would be good. 5b and 6 would probably be super worthless.

 

[nuke]

Here is my submission, froganamine. I believe you will find the methylenedioxy ring as well as dual 2-phenylethylpyridine rings absolutely of the utmost functional quality for producing DA and NE release.

p.s. Please stop posting unsubstantiated crap.

 

[Dragynfyr]

here is my submission, froganamine. I believe you will find the methylenedioxy ring as well as dual 2-phenylethylpyridine rings absolutely of the utmost functional quality for producing da and ne release.

P.s. Please stop posting unsubstantiated crap.

lol

 

[simstimstar]

Well we already have dragonfly why not froganamine. I'm waiting on mosquito, the utilmate meperidine related opiate. Believe you me, it is in development in a shack in rural cambodia. It's what the militant islamicists are going to use to take over the west.