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N&PD Moderators: Skorpio
🌟🌟 Social 🌟🌟 Rectify's molecular poetry thread
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Smyth2
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I thought at first that the benzoyl functional group came from local anesthetics since cocaine itself actually carries this functional group. But i noticed the heterocyclic alcohol also occurs in some of the tebanicline family of pyridyl ethers. E.g. A-84543 or Pozanicline (secondary amine in this case).Reminds me of ORG-37684. HT2.
Also that keto arrangement is half of the benzoyl-piperidine core of ketanserin & co.
If you want to know about local anesthetics containing a benzoyl group (not the PABA used in dimethocaine) consider Eucaine (alpha and beta), Amydricaine, Amylocaine, Cocaethylene, Elucaine, Hexylcaine, Isobucaine, Meprylcaine, Rhinocaine.
This goes some way to explaining why the expected action at first was local anesthetic (sodium channel blocker but not typically DRI with the occasional exceptions) but also finds a basis of how nicotinic receptor affinity can be rationalized.Last edited:
Rectify
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Thank You, Kind Sir.
It Made Me Think Of A
KNOW_O_TROPIC
1-methyl-2-(2-methylpyridine-3-yl)-pyrrolidine
Smyth2
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That's not typical of the patterning used in the production of nicotine analogs. Much more typically you will find that 6-substituted nicotine analogs are being manufactured synthetically in the laboratory (although not the nicotine obtained industrially which AI said is extracted from tobacco). 6-methyl nicotine for example is twice the potency of nicotine and a patent was published recently for this compound. Traces of 6-methylnicotine exist in nature but nothing like the quantity that can be manufactured artificially. The 6-chloro and 6-bromo nicotine analogs are profoundly potent and were ball-parked to be 15 times the potency of natural nicotine.Thank You, Kind Sir.
It Made Me Think Of A
KNOW_O_TROPIC
1-methyl-2-(2-methylpyridine-3-yl)-pyrrolidine
A fun fact is that artificial nicotine and analogs are made in the lab using GBL. I had an argument with AI last night about it when it claimed "nicotine and gbl are in different universes" but I eventually managed to prove it wrong but it took some persistance.
Altinicline has several syntheses but in all cases I think it is made from naturally obtained nicotine startng material.
Out of all the nicotinic agents only nicotine itself is interestingly suitable for vaping. I have not heard of arecoline vaping but i only heard negative things about its suitability for being used for the purpose. Rivanicline can be vaped but i was given the tip that it was less reinforcing than nicotine.
The 6-halo analogs of nicotine could be administered by transdermal delivery system. Interestingly 6-methylnicotine can be vaped but it would be more expensive than natural extracted to nicotine to manufacture and only twice the potency.Last edited:
